A5063442529- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Child Nutrition and Feeding Issues
- Pharmaceutical studies and practices
- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Bacterial biofilms and quorum sensing
- Respiratory Support and Mechanisms
- Pancreatitis Pathology and Treatment
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Pneumonia and Respiratory Infections
- Allergic Rhinitis and Sensitization
- Antibiotic Resistance in Bacteria
- Pancreatic and Hepatic Oncology Research
- Voice and Speech Disorders
- Child and Adolescent Health
- Dysphagia Assessment and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University Hospital Southampton NHS Foundation Trust
2016-2025
NIHR Southampton Biomedical Research Centre
2019-2025
National Institute for Health Research
2015-2024
Southampton Children's Hospital
2015-2024
University of Southampton
1996-2023
Respiratory Clinical Trials
2023
St. Vincent's University Hospital
2019
Aristotle University of Thessaloniki
2019
Centre Hospitalier Universitaire de Bordeaux
2019
Research Network (United States)
2018
<h3>Abstract</h3> <h3>Background</h3> Long Covid remains a relatively new phenomenon with emerging understanding. Estimated UK prevalence of three or more symptoms lasting for 12 weeks was 2.2% at the end 2021. The population-based French SAPRIS-SERO cohort has novel information about pattern that been obscured by controversy around original paper. <h3>Methods</h3> Secondary analysis used to describe and re-interpret persistent IgG seropositivity self-reported in survey. Participants...
Cystic fibrosis (CF) has entered the era of variant-specific therapy, tailored to genetic variants in Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR modulators, first therapy available, have transformed management CF. The latest standards care from European CF Society (2018) did not include guidance on as modulators were becoming established a novel therapy. We produced interim guide healthcare professionals provision for people with Here we provide evidence-based covering...
ABSTRACT The bacterial communities present in the oral cavity and lungs of 19 adult cystic fibrosis (CF) patients were compared by using terminal restriction fragment length polymorphism analysis 16S rRNA gene PCR products amplified from nucleic acids extracted directly bacteria clinical samples. Sputum samples not found to be subject profound contamination bacteria. Evidence colonization CF lung certain species was found.
Thirty two preschool children were entered into a double blind, placebo controlled study using intermittent budesonide to treat viral induced wheeze. Active treatment was either 800 micrograms twice day via spacer or 1600 and facemask in those too young use mouthpiece. Treatment started at the onset of an upper respiratory tract infection continued for seven days until symptoms had resolved 24 hours. Each child remained they completed one pair inhalers random order without need additional...
Newborn screening for cystic fibrosis remains controversial because improved pulmonary function has not been established. Studies to date have accounted differences in treatments delivered clinically diagnosed children and newborn-screened controls. Here, we compare outcomes treatment of patients within the newborn-screening reporting window (early-clinically diagnosed), those presenting after this period (late-clinically by newborn screening.In a cross-sectional analysis cohorts...
The treatment of severe asthmatics aged 1-3 years with budesonide administered via Nebuhaler and Laerdal facemask was assessed in a six month, double blind, placebo controlled study. Patients were randomised to (n = 20) or treatment. Daily symptom scores recorded by parents clinic visits occurred every weeks. Cough improved significantly budesonide: nocturnal daytime cough (0-2) fell mean (SEM) 0.4 (0.2) 0.5 (0.2); while the score increased 0.1 unchanged at 0.0 (0.2). All other data showed...
Fish allergy is the third most common food after milk and egg in parts of Europe, but there little data about prevalence South East Asia where it an important part regular diets.We aimed to obtain estimate population fish among older children Philippines, Singapore Thailand.The 14- 16-year-old 3 countries was evaluated using a structured written questionnaire which distributed students randomly selected secondary schools. An extended determine convincing on basis typical clinical...
Elexacaftor/Tezacaftor/Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator with the potential to improve exercise capacity. This case series of three adolescents CF aimed investigate whether 6 weeks treatment could capacity in CFTR naive CF.Three (14.0 ± 1.4 years) (FEV1 % predicted: 62.5 17.1; F508del/F508del genotype) completed an exhaustive maximal cardiopulmonary test on cycle ergometer determine peak oxygen uptake ( V̇$\dot{{\rm{V}}}$ O2peak ) and measure...
Abstract Background Drawing from previous studies, the traditional routine diagnostic microbiology evaluation of samples chronic respiratory conditions may provide an incomplete picture bacteria present in airways disease. Here, aim was to determine extent which gave a different assessment species sputa when analysed by using culture-independent assessment. Methods Six media used were inoculated with sputum twelve patients. Bacterial growth on these plates harvested and both RNA DNA...
Pancreatic exocrine insufficiency (PEI) affects patients with chronic pancreatitis (CP) and cystic fibrosis (CF) who produce insufficient digestive pancreatic enzymes. Common symptoms include steatorrhoea, diarrhea, abdominal pain. The objective of the study was to develop test content validity a patient-reported outcome (PRO) instrument assessing PEI their impact on health-related quality life. Instrument development supported by literature review, expert physician interviews (n = 10:...
Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with patients expert clinical input. This study evaluated the psychometric properties PEI-Q. 162 (CF = 71 CP 91), 62 diarrhoea-specific irritable bowel syndrome (IBS-D) 60 healthy controls completed 26-item PEI-Q Gastrointestinal...