A5089614991- Cystic Fibrosis Research Advances
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Child Nutrition and Feeding Issues
- Pneumonia and Respiratory Infections
- Tracheal and airway disorders
- Antifungal resistance and susceptibility
- Drug-Induced Adverse Reactions
- Immunodeficiency and Autoimmune Disorders
- Nematode management and characterization studies
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health and Medical Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmaceutical studies and practices
- Antibiotic Resistance in Bacteria
- Transplantation: Methods and Outcomes
- Eating Disorders and Behaviors
Charité - Universitätsmedizin Berlin
2015-2024
Humboldt-Universität zu Berlin
2011-2024
Freie Universität Berlin
1995-2023
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
Imperial College London
2019
Royal Brompton & Harefield NHS Foundation Trust
2019
Case Western Reserve University
2015-2016
University School
2015-2016
World Health Organization - Denmark
2015
Rigshospitalet
2015
<h3>Abstract</h3> <b>Objective</b> To determine the effects of age related, structured educational programmes on management moderate to severe atopic dermatitis in childhood and adolescence. <b>Design</b> Multicentre, randomised controlled trial. <b>Setting</b> Seven hospitals Germany. <b>Participants</b> Parents children with aged 3 months 7 years (n = 274) 8-12 102), adolescents 13-18 70), controls 244, n 83, 50, respectively). <b>Interventions</b> Group sessions standardised intervention...
Cystic fibrosis patients suffer from chronic lung infection and inflammation due to the secretion of viscous sputum. Sputum viscosity is caused by extracellular DNA, some which originates release neutrophil traps (NETs). During NET formation elastase (NE) partially processes histones decondense chromatin. NE abundant in CF sputum thought contribute tissue damage. Exogenous nucleases are a palliative treatment as they promote solubilization. We show that process reminiscent formation,...
Atopic dermatitis (AD) in childhood is a common disease with prevalence rates as high 20%. Its early onset infancy and its chronic relapsing course puts special burden on families. Supporting parents dealing the management of AD presents challenge for physicians. The objective this study was to determine effect structured parental training program managing children. Two‐hundred four families participated prospective, randomized controlled trial. Children (5 months 12 years age) had suffered...
Rationale: Lower respiratory tract infection with Pseudomonas aeruginosa (PA) is associated increased morbidity in patients cystic fibrosis (CF). Current treatment guidelines for inhaled antibiotics are not universally followed due to the perception of decreased efficacy, increasing resistance, drug intolerance, and high burden current aerosol antibiotics. New options CF pulmonary infections needed.Objectives: This study assessed efficacy safety a novel formulation levofloxacin (MP-376,...
The PEPITES (Peanut EPIT Efficacy and Safety) trial, a 12-month randomized controlled study of children with peanut allergy 4 to 11 years old, previously reported the safety efficacy epicutaneous immunotherapy (EPIT) for (250 μg, daily protein; DBV712 250 μg).We sought assess interim an additional 2 from ongoing (5-year treatment) PEOPLE (PEPITES Open-Label Extension) study.Subjects who completed were offered enrollment in PEOPLE. Following subjects had received μg underwent month-36...
The German Atopic Dermatitis Intervention Study (GADIS), which includes 823 children and adolescents, showed that age-related educational programmes are effective in the long-term management of atopic dermatitis. We investigated whether itch severity obtained scoring dermatitis (SCORAD) correlates with quality life coping behaviour parents. There were significant but low correlations between intensity. Itch sleeplessness significantly correlated. Significant parents measured. itching (8-12...
Rationale: Glutathione is the major antioxidant in extracellular lining fluid of lungs and depleted patients with cystic fibrosis (CF).Objectives: We aimed to assess glutathione delivered by inhalation as a potential treatment for CF lung disease.Methods: This randomized, double-blind, placebo-controlled trial evaluated inhaled subjects 8 years age older FEV1 40–90% predicted. Subjects were randomized receive 646 mg 4 ml (n = 73) or placebo 80) via an investigational eFlow nebulizer every 12...
Zusammenfassung Bei dem Krankheitsbild der Neurodermitis handelt es sich um eine chronische oder chronisch‐rezidivierende, nichtkontagiöse, entzündliche Hauterkrankung mit in Regel starkem Juckreiz. Darüber hinaus besteht ein Risiko für komplizierte Verläufe bakteriellen viralen Superinfektionen. Sowohl die genetische Prädisposition als auch zahlreiche Auslösefaktoren spielen Erstmanifestation und das Auftreten Erkrankungsschübe wichtige Rolle, so dass Therapiekonzepte vielfältig sind....
Background Staphylococcus aureus is an important pathogen in cystic fibrosis (CF). However, it not clear which factors are associated with worse lung function patients persistent S. airway cultures. Our main hypothesis was that high density their respiratory specimens would more likely experience worsening of disease than low bacterial loads. Methods Therefore, we conducted observational prospective longitudinal multi-center study and assessed the association between samples, co-infection...
Summary This guideline is an update from August 2020 the S2k‐guideline “Atopic dermatitis” published in 2015. The reason for updating this chapter of were current developments field systemic therapy atopic dermatitis. agreed recommendations treatment dermatitis present are based on scientific data. Due to approval dupilumab moderate severe dermatitis, which cannot be treated sufficiently with topical drugs alone, part has now been adapted and newly consented. indication therapeutic response...
<h3>BACKGROUND</h3> Cystic fibrosis is the most common inherited disease with a fatal outcome in industrialised nations. With improvement life expectancy, supporting patients and their families adapting to this chronic progressive has become increasingly important. The aim of present study was investigate relationship between health related quality (HRQOL) population, severity disease, cognitive/behavioural factors such as subjective perception ways coping. <h3>METHODS</h3> A sample 89...
Seven prepubertal children (age range 5.3 to 10.8 years) with severe heterozygous familial hypercholesterolemia (serum cholesterol concentration 416 +/- 85 mg/dL and low-density lipoprotein [LDL] 360 90 mg/dL) were first treated by dietary intervention, second sitosterol (3 x 2 g/d), third bezafibrate (2 200 mg/d). Each treatment period lasted 3 months. Subsequently, a combining half the dose of was administered for following 24 Diet alone reduced total LDL values 4.5% (not significant) 6.6%...
Inhaled antibacterial agents are used to manage chronic pulmonary infections in cystic fibrosis (CF) and non-CF bronchiectasis. However, established nebulized preparations impose a substantial time burden on patients. A dry powder formulation of ciprofloxacin for inhalation (ciprofloxacin DPI) has been developed using PulmoSphere™ (Novartis, Pharma AG, Basel, Switzerland) technology (administered T-326 inhaler) maximize activity convenience.This study investigated the tolerability...
Background In cystic fibrosis, highly variable glucose tolerance is suspected. However, no study provided within-patient coefficients of variation. The main objective this short report was to evaluate variability oral tolerance. Methods total, 4,643 standardized tests 1,128 fibrosis patients (median age at first test: 15.5 [11.5; 21.5] years, 48.8% females) were studied. Patients included clinically stable, non-pregnant, and had least two tests, with prior lung transplantation or systemic...
Summary Atopic dermatitis (AD) represents a pruritic, non‐contagious, chronic or chronically relapsing, inflammatory skin disease. The course of the disease may be complicated by bacterial viral superinfections. first manifestation and further flare‐ups are due to genetic predisposition also variety trigger factors. therapy regimen should adapted symptoms that actually present consider individual features as reported patients their parents. This short version German guideline on AD provides...
BackgroundHypersensitivity reactions to parenterally administered antibiotics (HRPA) are a substantial problem in managing CF. We conducted this observational study assess their nature and frequency as well risk factors.MethodsBy reviewing medical records conducting interviews, age, sex, FEV1, ∆F508-genotype, pseudomonal colonisation, allergy history, antibiotic exposure HRPA were recorded.ResultsOf 100 patients included the study, 60 had ≥1 HRPA. Overall, 3205 courses with 185 ascertained....
An increasing rate of respiratory colonization and infection in cystic fibrosis (CF) is caused by fungi the Scedosporium apiospermum species complex or Lomentospora prolificans (Sac-Lp). These rank second among filamentous colonizing CF airways, after Aspergillus fumigatus. However, epidemiology, clinical relevance risk pulmonary with Sac-Lp are rarely understood CF. The objective present prospective multicenter study was to pathogen distribution determine association factors patients...
Pancreatic exocrine insufficiency (PEI) affects patients with chronic pancreatitis (CP) and cystic fibrosis (CF) who produce insufficient digestive pancreatic enzymes. Common symptoms include steatorrhoea, diarrhea, abdominal pain. The objective of the study was to develop test content validity a patient-reported outcome (PRO) instrument assessing PEI their impact on health-related quality life. Instrument development supported by literature review, expert physician interviews (n = 10:...