A5069065260- Ophthalmology and Visual Impairment Studies
- Gastrointestinal motility and disorders
- Health Systems, Economic Evaluations, Quality of Life
- Childhood Cancer Survivors' Quality of Life
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Behavioral Health and Interventions
- Delphi Technique in Research
- Dermatology and Skin Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Adolescent and Pediatric Healthcare
- Allergic Rhinitis and Sensitization
- Child Nutrition and Feeding Issues
- Contact Dermatitis and Allergies
- Gastroesophageal reflux and treatments
- Corneal surgery and disorders
- Retinal Development and Disorders
- Medication Adherence and Compliance
- Mental Health Research Topics
- Family and Disability Support Research
- Ocular Surface and Contact Lens
- Sleep and related disorders
- Neurogenetic and Muscular Disorders Research
- Pharmaceutical Practices and Patient Outcomes
- Bipolar Disorder and Treatment
Adelphi Group (United Kingdom)
2016-2025
Northwestern University
2019
Oregon Health & Science University
2019
IQVIA (United States)
2019
Leo Pharma (Denmark)
2019
Dermatology Treatment & Research Center
2019
Nantes Université
2019
Adelphi Laboratory Center
2014
Centre Hospitalier de l’Université de Montréal
2006
Novartis (Canada)
2006
The Investigator Global Assessment of Chronic Hand Eczema (IGA-CHE) is a novel Clinician-Reported Outcome measure that allows investigators to assess cross-sectional CHE global disease severity using clinical characteristics erythema, scaling, lichenification/hyperkeratosis, vesiculation, oedema, and fissures as guidelines for overall assessment. This study aimed evaluate the psychometric properties IGA-CHE use an outcome in trials practice. Psychometric analyses were performed data from...
Fatigue is increasingly recognized as an important symptom in fibromyalgia (FM). Unknown however how fatigue experienced by individuals the context of FM. We conducted qualitative research order to better understand aspects that might be unique FM well impact it has on patients' lives. The data obtained informed development a conceptual model Open-ended interviews were with 40 (US [n = 20], Germany 10] and France 10]). Transcripts analyzed using methods based upon grounded theory identify...
Pancreatic exocrine insufficiency (PEI) affects patients with chronic pancreatitis (CP) and cystic fibrosis (CF) who produce insufficient digestive pancreatic enzymes. Common symptoms include steatorrhoea, diarrhea, abdominal pain. The objective of the study was to develop test content validity a patient-reported outcome (PRO) instrument assessing PEI their impact on health-related quality life. Instrument development supported by literature review, expert physician interviews (n = 10:...
Characterized by sudden onset of severe joint pain, swelling, redness, and tenderness to touch, gout 'flare ups' have a substantial impact on quality life (QoL). This research employed patient-centered approach explore the symptoms impacts gout, assess content validity existing patient-reported outcomes (PROs). Qualitative interviews were conducted with 30 US patients (non-tophaceous: n = 20, tophaceous: 10) five expert rheumatologists. Each interview included both concept elicitation (CE)...
Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with patients expert clinical input. This study evaluated the psychometric properties PEI-Q. 162 (CF = 71 CP 91), 62 diarrhoea-specific irritable bowel syndrome (IBS-D) 60 healthy controls completed 26-item PEI-Q Gastrointestinal...
Presbyopia is defined as the age-related deterioration of near vision over time which experienced in 80% people aged 40 years or older. Individuals with presbyopia have difficulty tasks that rely on vision. It not currently possible to stop reverse aging process causes presbyopia; generally, it corrected glasses, contact lenses, surgery, use a magnifying glass.This study aimed explore how individuals used social media describe their experience regard symptoms and impacts quality life.Social...
Chronic Hand Eczema (CHE) is an inflammatory skin disease of the hands. The Symptom Diary (HESD) a new patient-reported outcome measure worst severity core CHE signs/symptoms. This study aimed to evaluate content and psychometric validity HESD.
Abstract Background The Eye Allergy Patient Impact Questionnaire (EAPIQ) was developed based on a pilot study conducted in the US and focus groups with eye allergy sufferers Europe. purpose of this to present results psychometric validation EAPIQ. Methods One hundred forty six patients from two clinics completed EAPIQ twice over two-week period during fall winter seasons, along concurrent measures health status, work productivity, utility. Construct validity, reliability (internal...
Atopic dermatitis (AD) is a pruritic or painful dermatologic disease characterized by xerosis and eczema lesions.The symptoms/signs of AD can significantly impact patients' health-related quality life (HRQoL).This study aimed to qualitatively explore the adult adolescent experience AD.A targeted literature review qualitative concept elicitation interviews with clinicians (n = 5), patients 28), 20) were conducted elicit signs/ symptoms HRQoL impacts experienced.Verbatim transcripts analyzed...
Abstract Background The Chronic Ocular Pain Questionnaire (COP-Q) is a newly developed patient-reported outcome (PRO) measure intended to assess symptoms and impacts associated with Surface (COSP). This study assessed the psychometric properties of COP-Q determine adequacy as ‘fit-for-purpose’ instrument derive trial endpoints for future clinical studies in COSP. Methods Patients COSP completed daily four weeks on an electronic, touch-screen, tablet device part longitudinal, observational...
BackgroundX-linked hypophosphatemia (XLH) is a rare genetic disorder characterized by renal phosphate wasting and defective bone mineralization. Symptoms include pain, joint stiffness, fatigue. Published evidence regarding the patient experience of XLH sparse no XLH-specific outcome measures have been validated.ObjectivesTo understand symptoms, impacts, to evaluate face content validity Western Ontario McMaster Universities Osteoarthritis Index (WOMAC®) Brief Pain Inventory Short Form...
To compare the insights obtained about experience of individuals with presbyopia (age-related impaired near vision) across three different sources qualitative data: a structured targeted literature review, social media listening (SML) and concept elicitation (CE) interviews healthcare professionals (HCPs). The number concepts identified, depth data, cost time implications, value patient generated were explored compared for each method.
Purpose: Medication adherence is crucial for achieving clinical goals. drivers and behaviors were explored across multiple conditions, countries, medication schedules/modalities to develop a conceptual model of adherence, which could later be used support development patient-reported outcome (PRO) measure adherence. Patients Methods: Targeted review qualitative literature identified important concepts. Fifty-seven concept elicitation interviews conducted (USA n=21, Spain n=18, Germany n=18)....
Abstract Background The Hand Eczema Severity Index (HECSI) is a Clinician‐Reported Outcome measure of the severity hand eczema (HE). Objectives This study aimed to evaluate validity, reliability and ability detect change HECSI, HECSI‐75 HECSI‐90 as responder definitions. Methods Analyses were performed using data from sample n = 258 patients with Chronic (CHE) Phase 2b, randomised, double‐blind, vehicle‐controlled trial delgocitinib cream, pooled across treatment groups. measurement...