A5050536315- Delphi Technique in Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Heart Failure Treatment and Management
- Musculoskeletal pain and rehabilitation
- Menopause: Health Impacts and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Urinary Bladder and Prostate Research
- Medication Adherence and Compliance
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Diverse Approaches in Healthcare and Education Studies
- Dermatology and Skin Diseases
- Rheumatoid Arthritis Research and Therapies
- Hemophilia Treatment and Research
- Pelvic floor disorders treatments
- Evaluation and Performance Assessment
- Systemic Lupus Erythematosus Research
- Pharmacological Effects of Natural Compounds
- Pharmaceutical Economics and Policy
- Pharmaceutical industry and healthcare
- Estrogen and related hormone effects
- Effects of Vibration on Health
- Psoriasis: Treatment and Pathogenesis
- Cystic Fibrosis Research Advances
- Diabetes Management and Education
University Hospitals Bristol NHS Foundation Trust
2020
Health Economics and Outcomes Research (United Kingdom)
2017
Adelphi Group (United Kingdom)
2010-2016
CACI International (United Kingdom)
2014
Abstract Objective In evaluating the effectiveness of fibromyalgia (FM) therapies, it is important to assess impact those therapies on full array domains considered by both clinicians and patients. The objective this research was identify prioritize key clinically relevant impacted FM that should be evaluated outcome assessment instruments used in clinical trials, approach consensus among patients priority assessed care research. Methods Group achieved using Delphi method, a structured...
Fatigue is increasingly recognized as an important symptom in fibromyalgia (FM). Unknown however how fatigue experienced by individuals the context of FM. We conducted qualitative research order to better understand aspects that might be unique FM well impact it has on patients' lives. The data obtained informed development a conceptual model Open-ended interviews were with 40 (US [n = 20], Germany 10] and France 10]). Transcripts analyzed using methods based upon grounded theory identify...
Abstract Background A new caregiver burden questionnaire for heart failure (CBQ-HF v1.0) was developed based on previously conducted qualitative interviews with HF caregivers and input from clinical experts. Version 1.0 of the CBQ-HF included 41 items measuring associated caregiving in following domains: physical, emotional/psychological, social, impact caregiver’s life. Following initial development, next stage to evaluate caregivers’ understanding their conceptual relevance. Methods To...
The Food and Drug Administration patient-reported outcome (PRO) guidance provides standards for PRO development, but these bring scientific logistical challenges which can result in a lengthy expensive instrument development process. Thus, more pragmatic methods are needed alongside traditional approaches.Partnering with the National Ankylosing Spondylitis (AS) Society, we compared three eliciting patient experiences: 1) concept elicitation (CE) interviews 12 individuals AS, 2) "group...
Background: A subcutaneous (SC) formulation of rituximab (MabThera ® /Rituxan ) has been developed that could reduce administration time and improve patient satisfaction with treatment. The Rituximab Administration Satisfaction Questionnaire (RASQ) was created to assess patients' perceptions SC (RASQ-SC) or intravenous (RASQ-IV). We assessed the content validity psychometric properties RASQ in patients non-Hodgkin lymphoma. Methods: Face RASQ-SC RASQ-IV were qualitatively using 60-minute...
Summary Prophylactic use of treatment is important for good outcomes in haemophilia, yet adherence can be suboptimal. To better understand the relationship between and patients' beliefs about there a need to quantify attitudes. The aim this study was develop brief, clinically relevant, patient‐reported outcome ( PRO ) measure ease preference haemophilia treatment. A 40‐item questionnaire completed by male adults with from Austria, Germany, Italy, Spain UK . Robust statistical methods item...
Introduction: Fatigue is an important fibromyalgia (FM) symptom, but existing measures of fatigue are unlikely to meet regulatory standards for clinical trial use. We describe the development and validation Daily Diary Symptoms—Fibromyalgia (DFS-Fibro), a 24-hour recall, patient-reported outcome (PRO) measure in FM that administered electronically (ePRO). Methods: There were 3 phases work: 1) item generation based on concept elicitation interviews with patients, relevance confirmed by expert...
Recent advances in treatment for chronic hepatitis C (CHC) virus infection have shortened duration of and increased the likelihood success. To understand what unmet needs remain with available CHC treatments, patient interviews explored it is like to live undergo treatment. A subset also evaluated content validity comprehension patient-reported outcome (PRO) questionnaires use clinical trials. Sixty-five patients clinician-confirmed diagnosis provided informed consent completed Germany...
Abstract Not Available Disclosure: Study supported by Celgene.