A5057758300- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Hepatitis C virus research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Chronic Myeloid Leukemia Treatments
- Blood donation and transfusion practices
- Blood groups and transfusion
- Network Security and Intrusion Detection
- Trypanosoma species research and implications
- COVID-19 and Mental Health
- Complement system in diseases
- COVID-19 epidemiological studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemostasis and retained surgical items
- Spam and Phishing Detection
- Liver Disease and Transplantation
- Vitamin K Research Studies
- Anomaly Detection Techniques and Applications
- Pharmacogenetics and Drug Metabolism
- Blood properties and coagulation
- Recommender Systems and Techniques
- Chronic Lymphocytic Leukemia Research
- Insect symbiosis and bacterial influences
Special Olympics
2022-2023
University of Vermont
2015-2023
Newcastle upon Tyne Hospital
2006-2021
Newcastle upon Tyne Hospitals NHS Foundation Trust
2008-2020
Royal Victoria Infirmary
2004-2017
Palo Alto Research Center
2012-2015
National Health Service
2011
Freeman Hospital
2009
Christ University
2006
Christchurch Hospital
2000
In Paroxysmal nocturnal haemoglobinuria (PNH), pregnancy is associated with increased maternal and foetal complications to such an extent that the condition has been considered relatively contra-indicated in PNH. Eculizumab revolutionized treatment of We evaluate its use date. report on seven patients exposed eculizumab at different stages including first two receive drug from conception delivery. There was no evidence complement blockade cord blood samples taken appears safe this setting...
Malicious insiders pose significant threats to information security, and yet the capability of detecting malicious is very limited. Insider threat detection known be a difficult problem, presenting many research challenges. In this paper we report our effort on from large amounts work practice data. We propose novel approaches detect two types insider activities: (1) blend-in anomalies, where try behave similar group they do not belong to, (2) unusual change exhibit changes in their behavior...
Insider threat is a significant security risk for organizations. In this paper, we attempt to discover insider by identifying abnormal behavior in enterprise social and online activity data of employees. To end, process extract relevant features that are possibly indicative behavior. This includes extracted from including email communication patterns content, such as web browsing patterns, frequency, file machine access patterns. Subsequently, detect statistically with respect these using...
Chagas disease, considered a neglected disease by the World Health Organization, is caused protozoan parasite Trypanosoma cruzi, and transmitted >140 triatomine species across Americas. In Central America, main vector Triatoma dimidiata, an opportunistic blood meal feeder inhabiting both domestic sylvatic ecotopes. Given diversity of interacting biological agents involved in epidemiology having simultaneous information on dynamics parasite, vector, gut microbiome source would facilitate...
Mathematical modeling studies have suggested that pre-emptive school closures alone little overall impact on SARS-CoV-2 transmission, but reopening schools in the background of community contact reduction presents a unique scenario has not been fully assessed.We adapted previously published model using information from Shanghai to under various conditions. We investigated different strategies by combining patterns observed between age groups during both baseline and "lockdown" periods. also...
Background: The increasing incidence of thyroid cancer has resulted in the rate tripling over past 30 years. Reasons for this increase have not been established. Geostatistics and geographic information system (GIS) tools emerged as powerful geospatial technologies to identify disease clusters, map patterns trends, assess impact ecological socioeconomic factors (SES) on spatial distribution diseases. In study, these were used analyze a rural population. Methods: Thyroid socio-demographic...
Abstract About 20–25% of dengue virus (DENV) infections become symptomatic ranging from self-limiting fever to shock. Immune gene expression changes during progression severe have been documented in hospitalized patients; however, baseline or kinetic information is difficult standardize natural infection. Here we profile the host immunotranscriptome response humans before, during, and after infection with a partially attenuated rDEN2Δ30 challenge (ClinicalTrials.gov NCT02021968)....
<h3>Objective</h3> The extent that inherited bleeding disorders affect; number, size and location of bruises in young children <6 years. <h3>Design</h3> Prospective, longitudinal, observational study. <h3>Setting</h3> Community. <h3>Patients</h3> 105 with disorders, were compared 328 without a disorder classified by mobility: premobile (non-rolling/rolling over/sitting), early mobile (crawling/cruising) walking disease severity: severe factor VIII/IX/XI <1 IU/dL or type 3 von...
Hepatitis C virus (HCV) infection is the major cause of chronic liver disease in individuals with haemophilia. A wide spectrum severity found this group, ranging from mild hepatitis to cirrhosis. We have studied a cohort 87 anti‐HCV positive haemophiliacs who been infected HCV for 10–25 years and assessed relative value invasive non‐invasive methods evaluating disease. The was using ultrasound scan ( n = 77), upper GI endoscopy 50), laparoscopic inspection 33) biopsy 22). Invasive...
Abstract Research at long‐term catchment monitoring sites has generated a great volume, variety, and velocity of data for analysis stream water chemistry dynamics. To harness the potential these big extract patterns that are indicative underlying functional relationships, machine learning tools have advantages over traditional statistical methods, increasingly being applied dimension reduction, feature extraction, trend identification. Still, as examples complex systems, catchments...
Abstract Base excision repair (BER) is the main pathway protecting cells from continuous damage to DNA inflicted by reactive oxygen species. BER initiated glycosylases, each of which repairs a particular class base damage. NTHL1, bifunctional glycosylase, possesses both glycolytic and β-lytic activities with preference for oxidized pyrimidine substrates. Defects in human NTHL1 drive polyposis colorectal cancer. We report first X-ray crystal structure hNTHL1, revealing an open conformation...
Recombinant activated factor VII (rFVIIa/NovoSeven) has been advocated in the treatment of life-threatening haemorrhage, but appropriate clinical indications remain uncertain. The aim this study was to detect factors predictive outcome and incorporate them into a prognostically significant scoring system.Thirty-six patients received rFVIIa for uncontrolled surgical, traumatic or obstetric bleeding Northern Region UK over 45-month period. Clinical, laboratory data were examined....
Major obstetric haemorrhage remains a significant cause of maternal morbidity and mortality. Previous case reports suggest the potential benefit recombinant activated factor VII (rFVIIa: ) as haemostatic agent. We performed retrospective review use rVIIa in major Northern Region between July 2004 February 2007. Fifteen women received rFVIIa. The median patient age was 34 years. occurred antepartum (5 patients), intrapartum (1), postpartum (9). All an initial dose 90 mcg/kg rFVIIa one 2...