- Gestational Diabetes Research and Management
- Diabetes Management and Research
- Antimicrobial Resistance in Staphylococcus
- Hepatitis C virus research
- Mobile Health and mHealth Applications
- Pregnancy and preeclampsia studies
- Neonatal and Maternal Infections
- Cytomegalovirus and herpesvirus research
- Vitamin C and Antioxidants Research
- Breastfeeding Practices and Influences
- Hepatitis B Virus Studies
- Maternal and Perinatal Health Interventions
- Streptococcal Infections and Treatments
- Pediatric health and respiratory diseases
- Clostridium difficile and Clostridium perfringens research
- Bacterial biofilms and quorum sensing
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Liver Disease Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Emergency and Acute Care Studies
- Pregnancy and Medication Impact
- Urological Disorders and Treatments
- Ovarian cancer diagnosis and treatment
- Global Maternal and Child Health
- Endometrial and Cervical Cancer Treatments
AstraZeneca (United Kingdom)
2024
University of Minnesota
2021-2023
University of Iowa
2005-2022
University of Iowa Hospitals and Clinics
2000-2019
Medical Research Council
2017
University College London
2017
McMaster University
2016
Broomfield Hospital
2014
Clatterbridge Cancer Centre NHS Foundation Trust
2013
University of Utah
2008
Background: Rocuronium has an onset of action more rapid than other non‐depolarizing neuromuscular blocking agents, but it is unclear whether and succinylcholine give equivalent intubating conditions during rapid‐sequence induction anaesthesia. We performed this study to answer the question – are there clinically relevant differences between use rocuronium secure acceptable anaesthesia with propofol? Methods: Anaesthesia was induced using propofol 2.5 mg/kg in 349 ASA physical status grade...
<h3>Abstract</h3> <b>Objectives:</b> To investigate the relation between timing of birth and occurrence death related to an intrapartum event. <b>Design:</b> Analysis 107 206 births Welsh residents in 1993-5, including 608 cases stillbirth 407 neonatal identified all Wales perinatal survey, cause classified with clinicopathological system. <b>Subjects:</b> 79 normally formed babies stillborn or who died period, weight >1499 g, for whom was <b>Main outcome measures:</b> Relative risk due...
Abstract Objective —To determine whether detection of virusspecific serum antibodies correlates with resistance to challenge virulent feline herpesvirus 1 (FHV-1), calicivirus (FCV), and parvovirus (FPV) in cats percentages client-owned FHV-1, FCV, FPV. Design —Prospective experimental study. Animals —72 laboratory-reared 276 clientowned cats. Procedures —Laboratory-reared were vaccinated against FPV, using 3 commercial vaccines, or maintained as unvaccinated controls. Between 9 36 months...
The gene FLT1 produces at least two transcripts from a common transcription start site: full-length Flt1 contains 30 exons encoding membrane-bound VEGF receptor; soluble (sFlt1) shares the first 13 but utilizes poly(A) signal sequences within intron to create transcript that lacks downstream exons. To address mechanisms regulate human sFlt1, we mapped 3' end of sFlt1 mRNA and defined full extent its untranslated region (UTR). We identified 3.2 Kb is cleaved an alternatively spliced exon 14...
Recent published studies indicate a possible role for sFlt1 in the development of preeclampsia.
Seventeen months' supplementation of the diet with vitamin C in elderly residents an old persons' home failed to show any changes sublingual lesions, which on histological examination proved be aneurysmal dilatations venules. Nine 40 80 mg. daily was necessary before white-cell levels reached that found younger people. There a marked individual variation response.
The human cytomegalovirus (HCMV) major immediate-early (MIE) enhancer contains five functional cyclic AMP (cAMP) response elements (CRE). Because the CRE in their native context do not contribute appreciably to MIE enhancer/promoter activity lytically infected fibroblasts and NTera2 (NT2)-derived neurons, we postulated that they might have a role reactivation quiescently cells. Here, show stimulation of cAMP signaling pathway by treatment with forskolin (FSK), an adenylyl cyclase activator,...
Hepatitis C virus (HCV) infection is the major cause of chronic liver disease in individuals with haemophilia. A wide spectrum severity found this group, ranging from mild hepatitis to cirrhosis. We have studied a cohort 87 anti‐HCV positive haemophiliacs who been infected HCV for 10–25 years and assessed relative value invasive non‐invasive methods evaluating disease. The was using ultrasound scan ( n = 77), upper GI endoscopy 50), laparoscopic inspection 33) biopsy 22). Invasive...
ABSTRACT Pulsed-field gel electrophoresis (PFGE) was performed on 122 neonatal bloodstream isolates of group B streptococci (GBS) to further examine the relationship between macrolide resistance and serotype V GBS (GBS-V). Over one-third (35%) macrolide-resistant belonged a single PFGE subtype GBS-V, which also most common GBS-V noted in previous Centers for Disease Control Prevention surveillance studies. Erm methylase ( ermA ermB ) mechanism detected, present 12 20 GBS.
The 2008 National Confidential Enquiry into Patient Outcomes and Death highlighted an urgent need to improve the quality, safety efficiency of care for cancer patients following emergency presentation acute general hospitals. A network-wide oncology service (AOS) was therefore commissioned implemented on basis recommendations from Chemotherapy Advisory Group (NCAG). Through a continuous programme raising awareness regarding both role AOS necessity early patient referral teams, we have been...
In Brief Objective To determine the value of computed tomography (CT) scans for preoperatively detecting extrauterine-nodal disease and postoperative recurrent in patients with endometrial cancer. Methods We reviewed records 702 women primary carcinoma that was diagnosed between 1979 1993. Preoperative CT findings were compared pathologic to assess nodal disease. The yield clinically suspicious routine settings. Results Among 492 eligible analysis, 178 (36%) had a total 326 scans. 56 who...
A prospective study of 340 patients admitted to an acute geriatric male ward for a 12-month period was carried out determine the aetiology and incidence lower respiratory tract infection (LRTI) acquired either prior or after admission hospital. Over year, 120 (35%) were found have LRTI; specific in 44 (37%) patients. The pathogens most frequently isolated Haemophilus influenzae (11 patients), Streptococcus pneumoniae (9 patients) influenza (4 patients). further 8 (7 %) had antibody titres...
In Brief Postpartum mastitis was associated with toxic shock and methicillin-resistant Staphylococcus aureus.
Background: Management of diabetes in pregnancy is burdensome due to self-glucose monitoring, recording, and reporting demands. Cellular-enabled glucometers provide real-time transmission glucose values independent internet access cell phone data plans. We describe a quality improvement (QI) intervention that introduced cellular-enabled for use during pregnancies complicated by diabetes. Methods: Our aim was improve maternal control cohort insulin-requiring pregnant women enrolled...
Three Psychiatrists and three Geriatric Physicians working in a Regional Hospital Board area have investigated the problem of Psycho-Geriatric care. They made suggestions with regard to areas clinical responsibility based on needs behaviour rather than precise academic diagnoses. psychiatric geriatric resources available their areas, recommendations total numbers beds needed, but not about required for residential hostels, units or hospital accommodation respectively.