A5057275763- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Tracheal and airway disorders
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Child Nutrition and Feeding Issues
- Nosocomial Infections in ICU
- Inhalation and Respiratory Drug Delivery
- Emergency and Acute Care Studies
- Bacterial biofilms and quorum sensing
- Breastfeeding Practices and Influences
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Mobile Health and mHealth Applications
- Streptococcal Infections and Treatments
- Respiratory and Cough-Related Research
- Scoliosis diagnosis and treatment
- Cerebral Palsy and Movement Disorders
- Dysphagia Assessment and Management
- Child and Adolescent Health
- Smoking Behavior and Cessation
- Digital Mental Health Interventions
University Hospital Southampton NHS Foundation Trust
2012-2025
NIHR Southampton Biomedical Research Centre
2023-2025
Gallaudet University
2025
Southampton Children's Hospital
2013-2023
University of Southampton
2000-2023
NIHR Southampton Respiratory Biomedical Research Unit
2011-2019
Southampton General Hospital
2001-2019
National Institute for Health Research
2015-2017
Boston Children's Hospital
2015
Royal National Institute of Blind
2012
We examined the in vivo immune response of infants to natural respiratory syncytial virus (RSV) infection through analysis cytokine levels nasal lavage fluid and stimulated peripheral blood mononuclear cells. Eighty-eight babies with at least one parent atopy asthma were prospectively studied their first winter. Twenty-eight had an upper tract where RSV was detected, whom nine developed signs acute bronchiolitis. Nasal specimens assayed for interferon-gamma, interleukin (IL)-4, IL-10, IL-12...
Rationale: The triple-combination regimen elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to be safe and efficacious in children aged 6 through 11 years with cystic fibrosis at least one F508del-CFTR allele a phase 3, open-label, single-arm study. Objectives: To further evaluate the efficacy safety of ELX/TEZ/IVA age heterozygous for F508del minimal function CFTR mutation (F/MF genotypes) randomized, double-blind, placebo-controlled 3b trial. Methods: Children were randomized...
Previous studies in which molecular-based techniques have been used to identify the causative pathogens of respiratory tract infection investigated hospitalized children only. We report a prospective study designed determine frequency and clinical presentation community-acquired illness infancy associated with 8 common pathogens.Eighty-eight infants were monitored through their first winter. With each illness, examined, nasal lavage specimen was collected. Individual reverse...
Journal Article Eric C. Nystrom and R. A. Edwards, Ordinary Lives: Recovering Deaf Social History Through the American Census Get access Census, Amherst: University of Massachusetts Press, 2024. pp. 272. $32.99. paperback. IBSN 978-1-62534-763-3. Jannelle Legg Gallaudet University, USA [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Medicine, hkaf010, https://doi.org/10.1093/shm/hkaf010 Published: 20 February 2025
ABSTRACT Background People with cystic fibrosis (pwCF) often have multifactorial peripheral muscle abnormalities attributed to, for example, malnutrition, steroid use, altered redox balance and, potentially, CF‐specific intrinsic alterations. Malnutrition in CF now includes an increasing prevalence of overweight and obesity, particularly those receiving transmembrane conductance regulator (CFTR) modulator therapy (CFTRm). We aimed to characterise function body composition pwCF on...
Inhaled corticosteroid therapy (ICS) for asthma is currently modified according to symptoms and lung function. Fractional exhaled nitric oxide (FENO) has been demonstrated be a non-invasive marker of eosinophilic inflammation. Studies FENO-driven management show variable success. Objectives: This study aimed evaluate whether monitoring FENO can improve outpatient children with moderate severe using pragmatic design.Children aged 6–17 years were recruited. Their was stabilised before...
Little is known about the impact of COVID-19 and United Kingdom's (UK) national shielding advice on people with cystic fibrosis (CF) their families. This study explored experiences support needs children young adults (CYAs) CF, parents who have a child during pandemic.CYAs CF CYAs completed UK wide online survey open closed questions exploring experiences, information decision-making processes. Qualitative thematic content analysis descriptive quantitative analyses were undertaken.CYAs aged...
<b>Study Rationale</b> Cerebral palsy (CP) is a group of nonprogressive syndromes posture and motor impairment associated with lesions the immature brain. Spastic quadriplegia most severe form high incidence scoliosis, back pain, respiratory compromise, pelvic obliquity, poor sitting balance. Surgical stabilization spine an effective technique for correcting deformity restoring posture. The decision to operate in this patients challenging. <b>Objectives</b> aim study determine benefits...
Although premature infants are increasingly surviving the neonatal period, up to one-third develop bronchopulmonary dysplasia (BPD). Despite evidence that bacterial colonization of respiratory tract by certain bacteria may be a risk factor in BPD development, little is known about role these play. The aim this study was investigate use culture-independent molecular profiling methodologies identify potential etiological agents airway secretions. This used terminal restriction fragment length...
Multiplex, real-time PCR for the identification of Ureaplasma urealyticum and parvum was performed on nucleic acids extracted from sequential endotracheal aspirates obtained preterm neonates born at <29 weeks gestation ventilated more than 48 h admitted to two level 3 neonatal intensive care units. Specimens were shortly after birth sequentially up until extubation. One hundred fifty-two specimens (93.8%) contained material suitable analysis. spp. identified in 5 13 studied. In most cases,...
A meaningful analysis in research requires robust, valid data. Paper diaries allow the collection of data from individuals over time but are notorious for poor compliance and validity. SMS-technology is a novel method medical research. Time-tagged SMS transferred directly to an electronic file. We used collect symptoms peak flow rate (PEFR) meter readings 32 children with asthma. Parents responded first five daily 7 days during asymptomatic period then 14 cold. Compliance use PEFR system...
Background: People with cystic fibrosis (pwCF) often have multifactorial peripheral muscle abnormalities attributed to, for example, malnutrition, steroid use, altered redox balance and, potentially, CF-specific intrinsic alterations. Malnutrition in CF now includes an increasing prevalence of overweight and obesity, particularly those treated transmembrane conductance regulator (CFTR) modulators. We aimed to characterise function body composition pwCF on Elexacaftor/Tezacaftor/Ivacaftor...
<h3>Aims</h3> To investigate whether low dose Nitric Oxide (NO) enhances antibiotic therapy through disruption of <i>Pseudomonas aeruginosa</i> (PA) bacteria in biofilms patients with Cystic Fibrosis (CF). <h3>Background</h3> Bacterial present a major challenge due to their antimicrobial tolerance. In CF, chronic PA infection cannot be eradicated conventional antibiotics, leading increased hospitalisation, intravenous (IV) use, more rapid decline lung function and reduced survival. are...
<b>Aim:</b> To investigate the possibility of antenatal sensitisation to respiratory syncytial virus (RSV). <b>Methods:</b> A total 36 cord blood specimens were obtained from newborn infants; serum IgA was measured exclude maternal contamination. Cord peripheral mononuclear cells separated and cultured in presence either uninfected negative control or containing ultraviolet (UV) inactivated RSV. Proliferation assessed by tritiated thymidine incorporation. Supernatant cytokine concentrations...