Elke De Wachter
A5084720986- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Esophageal and GI Pathology
- Inhalation and Respiratory Drug Delivery
- Child Nutrition and Feeding Issues
- Dysphagia Assessment and Management
- Pediatric health and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Gastroesophageal reflux and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Tuberculosis Research and Epidemiology
- Antifungal resistance and susceptibility
- Respiratory and Cough-Related Research
- Diagnosis and treatment of tuberculosis
- Antimicrobial Resistance in Staphylococcus
- Pleural and Pulmonary Diseases
- Congenital Ear and Nasal Anomalies
- Pneumonia and Respiratory Infections
- Asthma and respiratory diseases
- Congenital Heart Disease Studies
- Mycobacterium research and diagnosis
- Airway Management and Intubation Techniques
Universitair Ziekenhuis Brussel
2016-2025
Vrije Universiteit Brussel
2014-2024
Antwerp University Hospital
2024
Imperial College London
2020
Medical University Pleven
2020
Centre Hospitalier Universitaire de Besançon
2020
Royal Brompton Hospital
2020
Case Western Reserve University
2012
University School
2012
Derriford Hospital
2012
<h3>Importance</h3> Delirium significantly worsens elective surgery outcomes and costs. risk is highest in elderly populations, whose surgical health care resource consumption (50%) exceeds their demographic proportion (15% to 18%) high-resource countries. Effective nonpharmacologic delirium prevention could safely improve these vulnerable patients, but data from procedure-specific studies are insufficiently compelling drive changes practice. approaches applicable different settings remain...
Background. Precise etiologic diagnosis in pediatric community-acquired pneumonia (CAP) remains challenging. Methods. We conducted a retrospective study of CAP etiology 2 groups patients who underwent flexible bronchoscopy (FOB) with bronchoalveolar lavage (BAL); children acute nonresponsive (NR-CAP; n = 127) or recurrent (Rec-CAP; 123). Procedural measures were taken to limit contamination risk and quantitative bacterial culture BAL fluid (significance cutoff point, ≥104 colony-forming...
Increased gastroesophageal reflux (GER) is common in children with cystic fibrosis (CF). We studied the occurrence of acid, weakly acidic (WA), and alkaline (WALK) CF evaluated a possible surrogate marker for risk gastric content aspiration.Twenty-four underwent impedance-pH monitoring detection acid (pH < 4), WA 4-7), WALK-GER > or = 7). In 11 children, cough was objectively recorded esophageal manometry symptom association probability calculated to determine reflux-cough relation. Presence...
Abstract Introduction Assessment of the reflux–cough association in children is challenging. Esophageal (impedance) pH recording sensitive to recognize reflux. However, cough recorded by an event marker, possibly lacks accuracy. We aim ed study exact time relationship between reflux and with chronic cough. Methods Twenty‐six (12 boys; 1–10.5 years) unexplained underwent ambulatory impedance–pH–manometry recordings. Manometry was used for precise recognition. Reflux assessed impedance‐pH...
Pharmacological rescue of mutant cystic fibrosis transmembrane conductance regulator (CFTR) in (CF) depends on the specific defect caused by different mutation classes. We asked whether a patient with rare p.Gly970Asp (c.2909G>A) could benefit from CFTR pharmacotherapy since similar missense p.Gly970Arg (c.2908G>C) was previously found to be sensitive potentiators vitro but not vivo. By complementary DNA transfection, we that both mutations are associated defective function amenable...
We tested the in vitro susceptibility of ceftazidime-avibactam and ceftolozane-tazobactam 13 other antibiotics against 91 Burkholderia cepacia complex (BCC) strains isolated from cystic fibrosis patients since 2012. The highest (82%) was found for trimethoprim-sulfamethoxazole.
Although different chronic arthritic diseases are defined by clinical factors like gender, psoriasis and auto-antibodies, the biology of inflamed joints while comparing remains neglected. Here, after curating an joint derived T-cell receptor (TCR) database, our new TRIASSIC tool identified 66303 significantly convergent TCR clonotypes. Clustering clonotypes showed that synovial fluid convergence clusters (SFCCs) characterized HLA-B27+ mediated (spondyloarthritis, SpA, enthesitis-related...
In children with persistent respiratory symptoms despite regular anti-asthma inhalation treatment, diagnostic investigations to exclude underlying disease are warranted. 124 were prospectively enrolled, and 24-h oesophageal pH measurement fibreoptic bronchoscopy bronchoalveolar lavage (BAL) performed. BAL fluid (BALF) was processed for neutrophil counting bacterial culture. Inflammation of the mucosa assessed. A structural abnormality central airways found in 47% subjects (40% females). 19%...
To investigate a computed tomographic (CT) protocol with iterative reconstruction at conventional radiography dose levels for the assessment of structural lung abnormalities in patients cystic fibrosis ( CF ).In this institutional review board-approved study, 38 (age range, 6-58 years; 21 <18 years and 17 >18 years) underwent investigative CT (at minimal exposure settings combined reconstruction) as replacement yearly follow-up posteroanterior chest radiography. Verbal informed consent was...
Purpose Different respiratory sampling methods exist to identify lower airway pathogens in patients with cystic fibrosis (CF), of which bronchoalveolar lavage (BAL) and expectorated sputum are considered the ‘gold standard’. Because BAL cannot be repeated limitless, diagnosis tract infections non-expectorating is challenging. Other techniques nasal swab, cough swab induced sputum. The purpose this study (NCT02363764) was compare concordance between microbiological yield expectorating...
Pseudomonas aeruginosa is the major respiratory pathogen causing severe lung infections among CF patients, leading to high morbidity and mortality. Once infection established, early antibiotic treatment able postpone transition chronic infection. In order optimize detection, we compared sensitivity of microbiological culture quantitative PCR (qPCR) for detection P. in samples not chronically infected patients. this national study, followed patients during periods between 1 15 months. For a...