A5043241965- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- vaccines and immunoinformatics approaches
- IL-33, ST2, and ILC Pathways
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Frailty in Older Adults
- Nutrition and Health in Aging
- T-cell and B-cell Immunology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vitamin D Research Studies
- Cardiovascular Function and Risk Factors
- Urticaria and Related Conditions
- Mosquito-borne diseases and control
- Chronic Disease Management Strategies
- Reproductive tract infections research
- Body Composition Measurement Techniques
- Chronic Kidney Disease and Diabetes
- Syphilis Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
Instituut voor Tropische Geneeskunde
2017-2025
Weatherford College
2023
Research Institute for Tropical Medicine
2023
University of Antwerp
2020
Drugs for Neglected Diseases Initiative
2019
UCLouvain
2012-2016
KU Leuven
2001-2016
Objectives To evaluate the predictive value of muscle strength and physical performance in oldest old for all‐cause mortality; hospitalization; onset disability, defined as a decline activities daily living ( ADL s), independent mass, inflammatory markers, comorbidities. Design A prospective, observational, population‐based follow‐up study. Setting Three well‐circumscribed areas Belgium. Participants Five hundred sixty participants aged 80 older were followed 33.5 months (interquartile range...
Asthma is a heterogeneous disease with various clinical, inflammatory and molecular phenotypes. We studied sputum cytokine mRNA expression patterns in an unselected group of adult asthma patients to characterize the underlying process.Differential cell counts (quantified by real-time PCR) were analysed on from 40 controls 66 asthmatic adults. A 'cytokine-high' profile was defined if levels for that particular exceeded 90th percentile value control population. Radar graphs used visualize...
Background: vitamin D deficiency is a well-known cause of bone loss and fractures but its association, especially among the oldest old, with muscle weakness less obvious. Objective: to investigate relationship between 25-hydroxyvitamin (25-OHD) performance in persons aged 80 years older. Methods: baseline results Belfrail study, prospective, population-based cohort study were used balance, grip strength gait speed relation 25-OHD serum levels 367 subjects. Results: sufficient level 30 ng/ml...
Abstract A large proportion of HIV-coinfected visceral leishmaniasis (VL-HIV) patients exhibit chronic disease with frequent VL recurrence. However, knowledge on immunological determinants underlying the course is scarce. We longitudinally profiled circulatory cellular immunity an Ethiopian HIV cohort that included developers. show VL-HIV high and persistent levels TIGIT PD-1 CD8 + /CD8 - T cells, in addition to a lower frequency IFN-γ suggestive impaired cell functionality. At single...
Abstract Leishmaniasis is caused by parasitic protozoa of the genus Leishmania and found widely across tropics sub-tropics, afflicting hundreds thousands people. The disease notoriously difficult to treat. Here, we present evidence existence persister-like cells in cultured populations, induced upon exposure normally lethal doses antimony, a used anti-leishmanial. Persisters are small fraction non-proliferative with reduced metabolism that adapted withstand variety environmental assaults,...
A subset of older people is at increased risk hospitalization and dependency. Emerging evidence suggests that immunosenescence reflected by an inverted CD4:8 ratio cytomegalovirus (CMV) seropositivity plays important role in the pathophysiology functional decline. Nevertheless, relation between outcome has rarely been investigated. Here, T-cell phenotypes 235 community-dwelling persons aged ≥81.5 years BELFRAIL study 25 younger (mean age 28.5 years) were analyzed using polychromatic flow...
Although different chronic arthritic diseases are defined by clinical factors like gender, psoriasis and auto-antibodies, the biology of inflamed joints while comparing remains neglected. Here, after curating an joint derived T-cell receptor (TCR) database, our new TRIASSIC tool identified 66303 significantly convergent TCR clonotypes. Clustering clonotypes showed that synovial fluid convergence clusters (SFCCs) characterized HLA-B27+ mediated (spondyloarthritis, SpA, enthesitis-related...
Previous studies indicated Clade I monkeypox virus infection to be associated with marked elevation of proinflammatory cytokines. This remains unexplored for II-associated disease, which has different clinical manifestations and prognosis. We used a 65-plex cytokine, chemokine, growth factor (CCG) panel analyze serum samples 100 male acute IIb mpox patients 26 healthy controls in Belgium. Cluster analyses revealed no strong or distinct CCG profiles distinguishing from but suggested trends...
► The international community has pledged through the Sustainable Development Goals to eliminate neglected tropical diseases by 2030.► Authors from 19 institutions around world call for urgent reflection and a change in mind-set garner support hasten progress towards achieving this fast approaching target.► They advocate an empowering approach that will propel political momentum, milestones targets accountability, new science drug development increased funding particularly G20 countries.
The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well understood. We use a systems immunology approach on three cohorts herpes zoster (HZ) patients and controls to investigate whether TCR against varicella-zoster virus (VZV) influences the risk HZ. show that CD4
Objective: previous studies have demonstrated an association between cytomegalovirus (CMV) infection and mortality in adults. In this prospective study, it was investigated whether these findings could be confirmed the oldest old. Methodology: data obtained from a observational cohort study (2008–2012) of 549 community-dwelling persons Belgium aged 80 older. Results: seventy-six percent were anti-CMV seropositive whom 37.5% had IgG titre highest tertile (>250 IU/ml). After median time...
The prevalence of chronic kidney disease (CKD) increases with age, and new glomerular filtration rate-estimating equations have recently been validated. epidemiology CKD in older individuals the relationship between a low estimated rate as calculated by these adverse outcomes remains unknown. Data from BELFRAIL study, prospective, population-based cohort study 539 aged 80 years older, were used. For every participant, five used to calculate based on serum creatinine and/or cystatin C values:...
BackgroundWe have conducted a single-arm trial evaluating monthly pentamidine secondary prophylaxis (PSP) to prevent visceral leishmaniasis (VL) relapse in Ethiopian human immunodeficiency virus–infected patients. Outcomes at 12 months of PSP been previously reported, supporting effectiveness and safety. However, remaining relapse-free after discontinuation is vital. We now report outcomes associated factors for period up 2.5 years initiating PSP, including 1-year follow-up discontinuation.
The occurrence and general applicability of the CD4:8 ratio as a surrogate predictor mortality among oldest old have only been tested in few longitudinal studies. Here, predictive value for with respect to role cytomegalovirus (CMV) infection was investigated. Using polychromatic flow cytometry, T-cell subsets 235 individuals aged 81.5 years or older were analyzed, data collected after mean period 3.3 years. hazard all-cause adjusted age, comorbidity, CMV serostatus increased 1.53-fold (95%...
Background In endemic regions, asymptomatic Leishmania infection is common. HIV patients, detection of could potentially identify those at risk visceral leishmaniasis (VL). However, data on the prevalence, incidence, and determinants infection, VL are lacking. Methods We conducted a cross-sectional survey single ART centre, followed by prospective cohort study amongst HIV-infected adults in care district hospital VL-endemic area North-West Ethiopia (9/2015-8/2016). Asymptomatic was detected...
In our ageing society, valvular heart diseases (VHD) have become an increasing public health problem. However, the lack of studies describing impact these on outcome very old subjects makes it difficult to appreciate their real clinical burden.Prospective, observational, population-based cohort study in Belgium. Five hundred fifty six aged 80 years and older were followed up for 5.1 ± 0.25 mortality 3.0 hospitalization. Echocardiograms performed at baseline. The Cumulative Illness Rating...
Diagnosis of a first-time visceral leishmaniasis (VL) infection in Ethiopia is established by use rapid diagnostic test (RDT) detecting antibodies against rK39, direct agglutination (DAT) and microscopy according to the national algorithm. The performance individual tests algorithm variable depends on several factors, one being HIV status. Limited data are available VL-HIV coinfected patients. Assessment DAT (ITM-A), rK39 ELISA (Serion) six RDT (Onsite Leishmania Ab CTK, Antigen ICT Xinjier,...