A5037454723- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Renal and related cancers
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- vaccines and immunoinformatics approaches
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- HIV Research and Treatment
- Contact Dermatitis and Allergies
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- Microbial Inactivation Methods
- Occupational exposure and asthma
- Viral gastroenteritis research and epidemiology
- Acute Lymphoblastic Leukemia research
- Viral Infectious Diseases and Gene Expression in Insects
- Hematopoietic Stem Cell Transplantation
- Cytokine Signaling Pathways and Interactions
University of Antwerp
2016-2025
Janssen (Belgium)
2020-2024
Infectious Diseases Institute
2007-2022
Antwerp University Hospital
2008-2019
The University of Sydney
2015
Anzac Research Institute
2015
Institute for Stem Cell Biology and Regenerative Medicine
2012
Instituut voor Tropische Geneeskunde
2006
Fund for Scientific Research
2000
Vlaams Instituut voor Biotechnologie
2000
Active immunization using tumor antigen-loaded dendritic cells holds promise for the adjuvant treatment of cancer to eradicate or control residual disease, but so far, most cell trials have been performed in end-stage patients with high loads. Here, a phase I/II trial, we investigated effect autologous vaccination 10 acute myeloid leukemia (AML). The Wilms’ 1 protein (WT1), nearly universal antigen, was chosen as an immunotherapeutic target because its established role leukemogenesis and...
Abstract Background Cell transplantation is likely to become an important therapeutic tool for the treatment of various traumatic and ischemic injuries central nervous system (CNS). However, in many pre-clinical cell therapy studies, reporter gene-assisted imaging cellular implants CNS potential gene and/or cell-based immunogenicity, still remain challenging research topics. Results In this study, we performed implantation experiments immunocompetent mice using autologous (syngeneic)...
Adoptive immunotherapy is gaining momentum to fight malignancies, whereby γδ T cells have received recent attention as an alternative cell source natural killer and αβ cells. The advent of largely due their ability recognize target tumor using both innate characteristic receptor (TCR)-mediated mechanisms, capacity enhance the generation antigen-specific responses, potential be used in autologous or allogeneic setting.In this study, we explored beneficial effect immunostimulatory cytokine...
Mobilization of bone marrow-derived endothelial progenitor cells (EPC) might explain exercise-induced improvement function. We assessed whether a maximal exercise bout could alter the number circulating EPC in healthy subjects and this effect is related to their cardiovascular risk profile. Additionally, we investigated possible mediators effect, namely nitric oxide (NO) bioavailability vascular growth factor (VEGF) release. Healthy (group 1, n = 11; group 2, 14) performed symptom-limited...
In an effort to raise protective antiviral immunity, dendritic cell immunotherapy was evaluated in six adults infected with human immunodeficiency virus (HIV)-1 and stable under highly active antiretroviral therapy (HAART).Autologous monocyte-derived cells electroporated mRNA encoding Gag a chimeric Tat-Rev-Nef protein were administered, whereas patients remained on HAART. Feasibility, safety, immunogenicity responses investigated.Dendritic vaccine preparation administration successful all...