A5103746967- Probiotics and Fermented Foods
- Genital Health and Disease
- Reproductive Biology and Fertility
- Cervical Cancer and HPV Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Archaeology and ancient environmental studies
- Immune cells in cancer
- Hearing Loss and Rehabilitation
- Peptidase Inhibition and Analysis
- Receptor Mechanisms and Signaling
- Protease and Inhibitor Mechanisms
- Sperm and Testicular Function
- Archaeology and Historical Studies
- Pacific and Southeast Asian Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Genomics and Phylogenetic Studies
- S100 Proteins and Annexins
- Diptera species taxonomy and behavior
- Periodontal Regeneration and Treatments
- Molecular Biology Techniques and Applications
- Connexins and lens biology
- Reproductive Physiology in Livestock
- Oral microbiology and periodontitis research
- Circadian rhythm and melatonin
University of Antwerp
2015-2024
Centre for Advanced Microscopy
2019
KU Leuven
2008-2017
Institute of Natural Sciences
2008-2014
Fujirebio (Belgium)
2000
Vanderbilt University Medical Center
2000
Age-related hearing impairment (ARHI), or presbycusis, is the most prevalent sensory in elderly. ARHI a complex disease caused by an interaction between environmental and genetic factors. Here we describe results of first whole genome association study for ARHI. The was performed using 846 cases controls selected from 3434 individuals collected eight centers six European countries. DNA pools were allelotyped on Affymetrix 500K GeneChip® each center separately. 252 top-ranked single...
Faunal evidence from the Fayum Neolithic is often cited in framework of early stock keeping Egypt. However, data suffer a number problems. In present paper, large faunal datasets new excavations at Kom K and W (4850–4250 BC) are presented. They clearly show that, despite presence domesticates, fish predominate animal bone assemblages. this sense, there continuity with earlier Holocene occupation Fayum, starting ca. 7350 BC. Domesticated plants animals appear first approximately 5400 The...
Monocyte-derived macrophages (Mϕs) are crucial regulators during muscularis inflammation. However, it is unclear which micro-environmental factors responsible for monocyte recruitment and anti-inflammatory Mϕ differentiation in this paradigm. Here, we investigate heterogeneity at different stages of inflammation determine how environmental cues can attract activate tissue-protective Mϕs. Results showed that induced marked alterations mononuclear phagocyte populations associated with a rapid...
Abstract Approximately 20% of sleeping sickness patients exhibit respiratory complications, however, with a largely unknown role the parasite. Here we show that tsetse fly-transmitted Trypanosoma brucei parasites rapidly and permanently colonize lungs occupy extravascular spaces surrounding blood vessels alveoli bronchi. They are present as nests multiplying exhibiting close interactions collagen active secretion extracellular vesicles. The local immune response shows substantial increase...
Long considered to fluctuate between pro- and anti-inflammatory states, it has now become evident that microglia occupy a variegated phenotypic landscape with relevance aging neurodegeneration. However, whether specific microglial subsets converge in or contribute both processes eventually affect brain function is less clear. To investigate this, we analyzed heterogeneity tauopathy mouse model (K18-seeded P301L) an accelerated (Senescence-Accelerated Mouse-Prone 8, SAMP8) using cellular...
In Paget's disease of the breast, epidermis nipple is infiltrated by large neoplastic cells glandular origin. It has been hypothesized that spread Paget through induced a motility factor acts via HER2/NEU receptor. To test this hypothesis, we characterized and purified released keratinocytes identified its target receptors in specimens from patients with SK-BR-3 breast adenocarcinoma cells, which overexpress HER2/NEU.We isolated keratinocyte-conditioned medium sequenced tryptic peptides....
Persistent high‐risk human papillomavirus (HPV) infection is strongly associated with development of high‐grade cervical intraepithelial neoplasia or cancer (CIN3+). In single type infections, serial type‐specific viral‐load measurements predict the natural history infection. infections multiple HPV‐types, individual profile could distinguish progressing HPV‐infections from regressing infections. A case‐cohort study was established using samples untreated women who developed CIN3+ ( n = 57)...
The preservation of the viability microorganisms in probiotic formulations is most important parameter ensuring adequate concentration live at time administration. formulation and processing techniques used to produce these can influence microbial viability. However, it also required that bacteria maintain their key capacities during processing, shelf life. In this study, we investigated impact spray-drying on different cell wall properties model strain Lactobacillus rhamnosus GG, including...
Although plant organ shapes are defined by spatio-temporal variations of directional tissue expansion, this is a little characterized aspect growth regulation. it well known that the hormone gibberellin increases leaf length/with ratio, its effects on cell expansion in growing largely unknown. To understand how rate and anisotropy establish typical monocotelydonous shape, we studied zone maize (Zea mays) with kinematic analysis three directions growth: proximo-distal, medio-lateral,...
Photoporation is an up-and-coming technology for the gentle and efficient transfection of cells. Inherent to application photoporation optimization several process parameters, such as laser fluence sensitizing particle concentration, which typically done one factor at a time (OFAT). However, this approach tedious runs risk missing global optimum. Therefore, in study, we explored whether response surface methodology (RSM) would allow more procedure. As case FITC-dextran molecules 500 kDa were...
Abstract Two concentrations of animal bones, almost exclusively from small mammals and wild birds, were found within the destruction debris a Roman bath complex in Sagalassos (SW Turkey). The overall species spectrum, skeletal element representation, fragmentation preservation condition bones indicate that they represent prey remains large nocturnal avian predator, more precisely eagle owl ( Bubo bubo ). Differences representation species' spectrum show two bone clusters derive pellets...
The intestinal wall has a complex topographical architecture. multi-layered network of the enteric nervous system and its intercellular interactions are difficult to map using traditional section-based or whole-mount histology. With advent optical clearing techniques, it become feasible visualize intact tissue organs in 3D. However, as yet, gap still needs be filled that no in-depth analysis been performed yet on potential different techniques for small intestine.The goal this study was...
We hypothesized that elevated non-esterified fatty acids (NEFA) modify in vitro bovine oviduct epithelial cell (BOEC) metabolism and barrier function. Hereto, BOECs were studied a polarized system with 24-h treatments at Day 9: (1) control (0 µM NEFA + 0% EtOH), (2) solvent 0.45% (3) basal (720 EtOH the compartment) (4) apical compartment). FITC-albumin was used for monolayer permeability assessment related to transepithelial electric resistance (TER). Fatty acid (FA), glucose, lactate...
In Africa, data is limited on quantitation of human papillomavirus (HPV) types in women with multiple infections. This study applied a real time PCR (qPCR) assay for detection, genotyping and HPV infections 90 tissue blocks South African cervical squamous cell carcinoma. One sample was subjected to laser micro-dissection qPCR. Four samples were negative β-globin these excluded from the analysis. The DNA positivity rate 93.0% (80/86). All 80 positives showed presence HR types; 68 only type...
The pulmonary neuroepithelial body (NEB) microenvironment (ME) consists of innervated cell clusters that occur sparsely distributed in the airway epithelium, an organization has so far hampered reliable selective gene expression analysis. Although NEB ME been suggested to be important for epithelial repair after ablation, little is known about their potential stem characteristics healthy postnatal lungs. Here we report on a large-scale analysis ME. A GAD67-GFP mouse model was used harbors...
The genus Lactobacillus is known to be extremely diverse and consists of different phylogenetic groups that show a diversity roughly equal the expected typical bacterial genus. One most prominent within this plantarum group, which contains understudied mudanjiangensis species. Before study, only one L. strain, DSM 28402 T , had been described, but without whole-genome analysis. In three strains classified as were isolated from carrot juice fermentations their sequence was determined,...