A5008950728- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Corneal Surgery and Treatments
- Congenital Diaphragmatic Hernia Studies
- Respiratory and Cough-Related Research
- Reproductive Biology and Fertility
- Ion channel regulation and function
- Extracellular vesicles in disease
- Neural dynamics and brain function
- Ion Channels and Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Mast cells and histamine
- Ion Transport and Channel Regulation
- MicroRNA in disease regulation
- Sperm and Testicular Function
- Angiogenesis and VEGF in Cancer
- Urological Disorders and Treatments
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
- Autophagy in Disease and Therapy
- Ocular Surface and Contact Lens
- Functional Brain Connectivity Studies
University of Antwerp
2016-2025
Centre for Advanced Microscopy
2022-2023
Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy
2019
National Academies of Sciences, Engineering, and Medicine
2019
Autophagy is triggered in vascular smooth muscle cells (VSMCs) of diseased arterial vessels. However, the role VSMC autophagy cardiovascular disease poorly understood. Therefore, we investigated effect defective on survival and phenotype its significance development postinjury neointima formation atherosclerosis. Tissue-specific deletion essential gene Atg7 murine VSMCs (atg7−/− VSMCs) caused accumulation SQSTM1/p62 accelerated stress-induced premature senescence as shown by cellular nuclear...
Thoracic aortic aneurysm and dissection (TAAD) is typically inherited in an autosomal dominant manner, but rare X-linked families have been described. So far, the only known gene FLNA, which associated with periventricular nodular heterotopia type of Ehlers-Danlos syndrome. However, mutations this explain a small number TAAD families.We performed targeted resequencing 368 candidate genes cohort 11 molecularly unexplained Marfan probands. Subsequently, Sanger sequencing BGN 360 male 155...
LiQD Cornea is a liquid in situ gelling, pro-regeneration hydrogel for treating corneal blindness and repairing perforations.
Intraplaque (IP) angiogenesis is a key feature of advanced atherosclerotic plaques. Because IP vessels are fragile and leaky, erythrocytes released phagocytosed by macrophages (erythrophagocytosis), which leads to high intracellular iron content, lipid peroxidation cell death. In vitro experiments showed that erythrophagocytosis induced non-canonical ferroptosis, an emerging type regulated necrosis may contribute plaque destabilization. Erythrophagocytosis-induced ferroptosis was accompanied...
Metal contaminated soils are increasing worldwide. Metal-tolerant plants growing on metalliferous fascinating genetic and microbial resources. Seeds can vertically transmit endophytic microorganisms that assist next generations to cope with environmental stresses, through yet poorly understood mechanisms. The aims of this study were identify the core seed endophyte microbiome pioneer metallophyte Crotalaria pumila throughout three generations, better understand plant colonisation...
Abstract STUDY QUESTION Can we use a mitochondrial-targeted antioxidant (Mitoquinone) during in vitro embryo culture to rescue developmental competence of oocytes matured under lipotoxic conditions, exhibiting mitochondrial dysfunction and oxidative stress? SUMMARY ANSWER Supplementation media with Mitoquinone reduced stress prevented uncoupling embryos derived from metabolically compromised vitro, leading higher blastocyst rates lower blastomeric apoptosis. WHAT IS KNOWN ALREADY Maternal...
Monocyte-derived macrophages (Mϕs) are crucial regulators during muscularis inflammation. However, it is unclear which micro-environmental factors responsible for monocyte recruitment and anti-inflammatory Mϕ differentiation in this paradigm. Here, we investigate heterogeneity at different stages of inflammation determine how environmental cues can attract activate tissue-protective Mϕs. Results showed that induced marked alterations mononuclear phagocyte populations associated with a rapid...
Abstract Approximately 20% of sleeping sickness patients exhibit respiratory complications, however, with a largely unknown role the parasite. Here we show that tsetse fly-transmitted Trypanosoma brucei parasites rapidly and permanently colonize lungs occupy extravascular spaces surrounding blood vessels alveoli bronchi. They are present as nests multiplying exhibiting close interactions collagen active secretion extracellular vesicles. The local immune response shows substantial increase...
Plants and their associated bacteria play a crucial role in constructed wetlands. In this study, the impact of different levels pollution bioaugmentation with indigenous strains individually or consortia was investigated on composition endophytic microbial communities Juncus acutus. Five treatments were examined compared where wetland plant exposed to increasing metal (Zn, Ni, Cd) emerging pollutants (BPA, SMX, CIP), enriched combinations single mixed strains. High had negative effect alpha...
Abstract Microglia, the immunocompetent cells of central nervous system (CNS), play an important role in maintaining cellular homeostasis CNS. These secrete immunomodulatory factors including nanovesicles and participate removal debris by phagocytosis or autophagy. Accumulating evidence indicates that specifically exchange small extracellular vesicles (EVs), participates physiology disease through intercellular communication. However, contribution microglial‐derived (M‐EVs) to maintenance...
Intraplaque neovascularization is an important feature of unstable human atherosclerotic plaques. However, its impact on plaque formation and stability poorly studied. Because proliferating endothelial cells generate up to 85% their ATP from glycolysis, we investigated whether pharmacological inhibition glycolytic flux by the small-molecule 3PO (3-[3-pyridinyl]-1-[4-pyridinyl]-2-propen-1-one) could have beneficial effects composition. Approach Results: ApoE-/- (apolipoprotein E deficient)...
Abstract In the last decade, extracellular vesicles (EVs) have become a hot topic. The findings on EVs content and effects made them major field of interest in cancer research. EVs, are able to be internalized through integrins expressed parental cells, tissue specific manner, as key step progression pre-metastatic niche formation. However, this specificity might lead new opportunities treatment by using devices for drug delivery. For future applications cancer, improved protocols methods...
Abstract Background and Aims There is evidence for a disturbed intestinal barrier function in inflammatory bowel diseases [IBD] but the underlying mechanisms are unclear. Because mucins represent major components of mucus mucin expression reported colon IBD patients, we studied association between expression, inflammation permeability experimental colitis. Methods We quantified 4-kDa FITC-dextran cytokines, mucins, junctional polarity proteins at dedicated time points adoptive T cell...
Abstract Maternal obesity can cause reduced oocyte quality and subfertility. Mitochondrial dysfunction plays a central role here, most often inbred mouse models are used to study these pathways. We hypothesized that the genetic background influence impact of high fat diet (HFD)-induced on quality. compared C57BL/6 (B6) outbred Swiss strains after feeding HFD for 13w. HFD-mice had increased body weight gain, hypercholesterolemia, lipid droplet (LD) accumulation in both strains. LD...
Abstract Background There is increasing evidence that Parkinson’s disease (PD) might start in the gut, thus involving and compromising also enteric nervous system (ENS). At clinical onset of majority dopaminergic neurons midbrain already destroyed, so lack early biomarkers for represents a major challenge developing timely treatment interventions. Here, we use transgenic A30P-α-synuclein-overexpressing PD mouse model to identify appropriate candidate markers gut before hallmark symptoms...
There is an unmet clinical need for pharmacologic treatment metabolic dysfunction-associated steatotic liver disease (MASLD). Hepatocyte cell death a hallmark of this highly prevalent chronic disease, but the dominant type remains uncertain. Here we report that ferroptosis, iron-catalyzed mode regulated death, contributes to MASLD. Unsupervised clustering in cohort biopsy-proven MASLD patients revealed subgroup with hepatic ferroptosis signature and lower glutathione peroxidase 4 (GPX4)...
ABSTRACT Human transmembrane serine protease 2 (TMPRSS2) has garnered substantial interest due to its clinical significance in various pathologies, notably pivotal role viral entry into host cells. The development of effective strategies target TMPRSS2 is a current area intense research and necessitates consistent source active with sufficient stability. Here, we comprehensively characterised human seminal‐fluid extracellular vesicles (SF‐EVs, also referred as prostasomes), bearing native...
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Systemic vascular endothelial growth factor inhibition, in combination with chemotherapy, improves the outcome of patients metastatic cancer. Peripheral sensory neuropathies occurring receiving both drugs are attributed to chemotherapy. Here, we provide unprecedented evidence that receptor inhibitors trigger a painful neuropathy and aggravate paclitaxel-induced mice. By using transgenic mice altered neuronal expression, systemic inhibition receptors was shown interfere endogenous...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES