A5060220359- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Endoplasmic Reticulum Stress and Disease
- Pancreatitis Pathology and Treatment
- Liver Diseases and Immunity
- Wnt/β-catenin signaling in development and cancer
- Liver Disease and Transplantation
- Cardiovascular Disease and Adiposity
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Blood properties and coagulation
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Lipid metabolism and biosynthesis
- Bariatric Surgery and Outcomes
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Diabetes Management and Research
Antwerp University Hospital
2016-2025
University of Antwerp
2015-2024
Beijing Red Cross Blood Center
2013
University of California, San Diego
2013
KU Leuven
2013
Endocrinology Research Center
2013
Diabetes Australia
2009-2011
Université de Lille
2010
Institut Pasteur de Lille
2010
Inserm
2010
There is an unmet need for noninvasive tests to improve case-finding and aid primary care professionals in referring patients at high risk of liver disease.
An independent role of nonalcoholic fatty liver disease (NAFLD) in the development cardiovascular has been suggested, probably mediated through increased levels prothrombotic factors. Therefore, we examined whether NAFLD is linked to a state, independently metabolic risk factors large single-center cohort overweight/obese patients. Patients presenting obesity clinic underwent detailed and assessment, including an extensive panel coagulation If was suspected, biopsy proposed. A series 273...
Hypertriglyceridemia and fatty liver are common in patients with type 2 diabetes, but the factors connecting alterations glucose metabolism plasma lipid remain unclear. Apolipoprotein CIII (apoCIII), a regulator of hepatic triglyceride metabolism, is elevated diabetes. In this study, we analyzed whether apoCIII affected by altered metabolism.Liver-specific insulin receptor-deficient mice display lower mRNA levels than controls, suggesting that other regulate vivo. Glucose induces...
Nonalcoholic fatty liver disease prevalence is soaring with the obesity pandemic, but pathogenic mechanisms leading to progression toward active nonalcoholic steatohepatitis (NASH) and fibrosis, major causes of liver-related death, are poorly defined. To identify key components during NASH we investigated transcriptome in a human cohort patients. The transition from histologically proven fibrosis was characterized by gene expression patterns that successively reflected altered functions...
•Muscle fat content is higher in patients with obesity and NASH than those NAFL.•There no low muscle mass obesity-associated NASH.•Muscle strongly associated cardinal histological features of NASH.•NASH improvement a significant decrease content. Background & AimsStudies exploring the relationship between non-alcoholic fatty liver disease (NAFLD) are scarce. Herein, we aimed to evaluate association infiltration biopsy-assessed NAFLD obesity.MethodsAt inclusion (n = 184) 12 months after...
Bile acids (BAs) are signaling molecules controlling energy homeostasis that can be both toxic and protective for the liver. BA alterations have been reported in obesity, insulin resistance (IR), nonalcoholic steatohepatitis (NASH). However, whether contribute to NASH independently of metabolic status is unclear. To assess associated with body mass index IR. Patients visiting obesity clinic Antwerp University Hospital (a tertiary referral facility) were recruited from 2006 2014. Obese...
Objective Endocannabinoids (ECs) control metabolism via cannabinoid receptors type 1 (CB ). Their plasma levels are elevated in overweight 2 diabetes (T2D) and obese patients, decrease postprandially normoweight individuals. We investigated two different cohorts of nonobese or volunteers whether oral glucose tolerance tests (OGTT) acute insulin infusion during euglycemic hyperinsulinemic clamp affect EC levels. Design methods OGTT was performed ten patients (body mass index (BMI)=35.8 kg/m ,...
Aim: To determine the effect of whole body vibration (WBV), combined with caloric restriction, on weight, composition and metabolic risk factors in overweight obese adults. Methods: A randomized, controlled study a 6-month intervention period 'no intervention' follow-up. 61 79 participants completed study. Data were collected at baseline 3, 6 12 months control group (CONTROL), diet only (DIET), plus fitness (FITNESS) WBV (VIBRATION). Results: Weight decreased significantly all three groups....
Intestinal dysbiosis and elevated lipopolysaccharides (LPS) levels have been implicated in the development of obesity, insulin resistance non-alcoholic steatohepatitis (NASH). In order to determine if LPS are patients with NASH compared fatty liver (NAFL) and, correlated histological severity disease (NAFLD) we LPS, markers bioactivity pro-inflammatory cytokines/chemokines undergoing bariatric surgery. At time surgery a biopsy was taken allowing stratification into well-delineated subgroups...
Haemodynamic impairment, inflammatory mediators and glucose metabolism disturbances have been implicated in the pathogenesis of Non-Alcoholic Fatty Liver Disease (NAFLD). To investigate cytokine profile NAFLD patients peripheral (P) hepatic venous (HV) blood to compare with histology, haemodynamic metabolic parameters. 40 obese an indication for a transjugular liver biopsy were enrolled. Besides extended work-up, interleukin (IL) 1B, IL4, IL6, IL10, IL23, tumour necrosis factor (TNF) α...
The composite histological endpoint comprising nonalcoholic steatohepatitis (NASH) and NAFLD activity score ≥4 advanced fibrosis (F ≥ 2) ("fibrotic NASH") is becoming an important diagnostic target in NAFLD: it currently used to select patients for inclusion phase III therapeutic trials will ultimately be indicate treatment clinical practice once the new drugs are approved.To develop a blood test specifically dedicated this of interest.Eight Hundred forty-six biopsy-proven from three centres...
Abstract Context Plasma branched chain amino acid (BCAA) concentrations correlate positively with body mass index (BMI), measures of insulin resistance (IR), and severity nonalcoholic fatty liver disease (NAFLD). Moreover, plasma BCAA also differ between the sexes, which display different susceptibilities to cardio-metabolic diseases. Objective Assess whether associate NAFLD independently BMI, IR, sex. Patients visiting obesity clinic Antwerp University Hospital were consecutively recruited...