A5058259266- Gastrointestinal motility and disorders
- Neuropeptides and Animal Physiology
- Respiratory and Cough-Related Research
- Ion Channels and Receptors
- Eicosanoids and Hypertension Pharmacology
- Biomedical Ethics and Regulation
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Chemical Synthesis and Analysis
- Clinical Laboratory Practices and Quality Control
- COVID-19 Clinical Research Studies
- Drug Solubulity and Delivery Systems
- Child Nutrition and Feeding Issues
- Probiotics and Fermented Foods
- Pharmacological Effects of Natural Compounds
- Eosinophilic Esophagitis
- Long-Term Effects of COVID-19
- Peptidase Inhibition and Analysis
- Free Radicals and Antioxidants
- Diabetes Treatment and Management
- Monoclonal and Polyclonal Antibodies Research
- Health and Medical Research Impacts
- Click Chemistry and Applications
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 and COVID-19 Research
University of Antwerp
2018-2025
KU Leuven
2023
AZ Groeninge
2023
University of Liège
2023
Universitair Ziekenhuis Leuven
2023
Antwerp University Hospital
2023
ABSTRACT Human transmembrane serine protease 2 (TMPRSS2) has garnered substantial interest due to its clinical significance in various pathologies, notably pivotal role viral entry into host cells. The development of effective strategies target TMPRSS2 is a current area intense research and necessitates consistent source active with sufficient stability. Here, we comprehensively characterised human seminal‐fluid extracellular vesicles (SF‐EVs, also referred as prostasomes), bearing native...
Background and Purpose Serine proteases have been re suggested as important mediators of visceral pain. We investigated their effect by using newly developed serine protease inhibitors with a well‐characterized inhibitory profile in rat model post‐inflammatory irritable bowel syndrome (IBS). Experimental Approach Colitis was induced rats receiving intrarectal trinitrobenzenesulphonic acid; controls received 0.9% NaCl. Colonoscopies were performed on day 3, to confirm colitis, later until...
Activity-based probes (ABP) are molecules that bind covalently to the active form of an enzyme family, making them attractive tool for target and biomarker identification drug discovery. The present study describes synthesis biochemical characterization novel activity-based targeting trypsin-like serine proteases. We developed extensive library with “clickable” affinity tags a diaryl phosphonate warhead. A wide diversity was achieved by including natural amino acid analogs as well basic...
Dysregulation of the protease–antiprotease balance in gastrointestinal tract has been suggested as a mechanism underlying visceral hypersensitivity conditions such inflammatory bowel disease (IBD) and irritable syndrome (IBS). We aimed to study potential therapeutic role an intracolonically administered serine protease inhibitor for treatment abdominal pain post-inflammatory rat model IBS. An enema containing 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used induce colitis male...
The protease activity in inflammatory bowel disease (IBD) and irritable syndrome has been studied extensively using synthetic fluorogenic substrates targeting specific sets of proteases. We explored activities colonic tissue from a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis rat model by investigating the cleavage bioactive peptides. Pure trypsin- elastase-like proteases on one hand rats with TNBS-induced acute or post-inflammatory phase other, were incubated relevant peptides...
Background: Serine proteases are believed to play a key role in the origin of abdominal pain IBD and IBS. We previously demonstrated reduction visceral post-inflammatory IBS rat model after single intraperitoneal or intracolonic administration serine protease inhibitor. The aim this study was investigate efficacy inhibition on two different animal models involving colonic insult based either acute inflammation neonatal irritation. Moreover, profiling explored colitis model. Methods: An...
Coronavirus disease 2019 (COVID-19) is a viral lower respiratory tract infection caused by the highly transmissible and pathogenic SARS-CoV-2 (severe acute respiratory-syndrome coronavirus-2). Besides failure, systemic thromboembolic complications are frequent in COVID-19 patients suggested to be result of dysregulation hemostatic balance. Although several markers coagulation fibrinolysis have been studied extensively, little known about effect on potent antifibrinolytic enzyme...
Cardiovascular disease is the leading cause of death in industrialized countries, and now also emerging countries.Chest pain a common presentation for hospital admissions.Emergency department (ED) admissions chest represent approximately 20% acute admissions, delays investigation management these patients increase pressure on EDs medical departments.Given that majority cases do not involve myocardial infarction, clinicians rely troponins as gold standard diagnosing this condition.Notably, if...