A5020458551- Neuropeptides and Animal Physiology
- Monoclonal and Polyclonal Antibodies Research
- Platelet Disorders and Treatments
- T-cell and B-cell Immunology
- Balance, Gait, and Falls Prevention
- Motor Control and Adaptation
- Immune Cell Function and Interaction
- Pain Mechanisms and Treatments
- Gastrointestinal motility and disorders
- Cerebral Palsy and Movement Disorders
- Action Observation and Synchronization
- Virtual Reality Applications and Impacts
- Sports Performance and Training
- Gut microbiota and health
- Hemophilia Treatment and Research
- Cancer, Stress, Anesthesia, and Immune Response
- Receptor Mechanisms and Signaling
- Sports Dynamics and Biomechanics
- Stroke Rehabilitation and Recovery
- Immunodeficiency and Autoimmune Disorders
- Botulinum Toxin and Related Neurological Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes and associated disorders
- Child Nutrition and Water Access
Université Toulouse III - Paul Sabatier
2014-2024
Digestive Health Research Institute
2016-2024
École Nationale Vétérinaire de Toulouse
2016-2024
Inserm
2015-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023-2024
Université Paris Cité
2012-2024
Université de Toulouse
2014-2024
Institut des Sciences du Sport-Santé de Paris
2019-2023
Institut National du Sport, de l'Expertise et de la Performance
1995-2022
Clinique de La Source
2022
Lactic acid–producing bacteria engineered to produce the antiprotease Elafin restore colon homeostasis in mice with colitis and protect human tissue from inflammation.
Objective Data from clinical research suggest that certain probiotic bacterial strains have the potential to modulate colonic inflammation. Nonetheless, these data differ between studies due used and poor knowledge of their mechanisms action. Design By mass-spectrometry, we identified quantified free long chain fatty acids (LCFAs) in probiotics assessed effect one them mouse colitis. Results Among all LCFAs by mass spectrometry Escherichia coli Nissle 1917 (EcN), a for treatment multiple...
Tool use can be considered a particularly useful model to understand the nature of functional actions. In 3 experiments, tool-use actions typified by stone knapping were investigated. Participants had detach flakes from flint core through conchoidal fracture. Successful flake detachment requires controlling various parameters simultaneously. Accordingly, our goals twofold: (a) examine regulation kinetic energy varying properties hammers and goal, (b) characterize difference in action across...
Quiescent phases of inflammatory bowel disease (IBD) are often accompanied by chronic abdominal pain. Although the transient receptor potential vanilloid 1 (TRPV1) ion channel has been postulated as an important mediator visceral hypersensitivity, its functional role in postinflammatory pain remains elusive. This study aimed at establishing TRPV1 peripheral sensitization underlying context colitis. Wild-type and TRPV1-deficient mice were separated into three groups (control, acute colitis,...
Administration of the probiotic Escherichia coli strain Nissle 1917 (EcN) decreases visceral pain associated with irritable bowel syndrome. Mutation clbA, a gene involved in biosynthesis secondary metabolites, including colibactin, was previously shown to abrogate EcN activity. Here, we show that EcN, but not an isogenic clbA mutant, produces analgesic lipopeptide. We characterize lipoamino acids and lipopeptides produced by mutant online liquid chromatography mass spectrometry. One these...
Pooled normal polyspecific IgG for therapeutic use (IVIg) contain anti-idiotypes against idiotypic determinants expressed by autoantibodies from patients with a variety of autoimmune diseases. In the present study, antiidiotypes in IVIg are shown to recognize cross-reactive idiotype on human anti-thyroglobulin (TG) autoantibodies, that was defined heterologous antiidiotypic antibodies, termed anti-T44 antibodies. The T44 is located outside antibody-combining site anti-TG autoantibodies....
Spontaneous inhibitors of factor VIII (FVIII) are pathogenic IgG autoantibodies restricted isotypic heterogeneity found in the plasma patients presenting with bleeding episodes and low levels FVIII. We now report presence a natural FVIII-neutralizing activity 85 500 samples (17%) from healthy donors. FVIII-inhibitory was present F(ab')2 fragments purified dose-dependent. The titer anti-FVIII antibodies normal ranged between 0.4 (threshold detection) 2.0 Bethesda units. Anti-FVIII also...
The physiological functions of human TCRVgamma9Vdelta2(+) gammadelta lymphocytes reactive to non-peptide phosphoantigens contribute cancer immunosurveillance and immunotherapy. However, their regulation by mesenchymal stem cells (MSC), multipotent immunomodulatory progenitor able infiltrate tumors, has not been investigated so far. By analyzing freshly isolated primary cell lines stimulated with synthetic phosphoantigen or B-cell lymphoma in the presence MSC, we demonstrated that MSC were...
Abstract Pain is an inherent component of inflammation often accompanying immune response. A large spectrum molecules released within the inflamed tissue induces pain by stimulating primary afferent neurons in situ. Activity sensitive fibers can be counteracted local opioid release leukocytes. In this study, we investigated endogenous regulation CFA-induced inflammatory context adaptive T cell The nociceptive response to mechanical stimuli was studied using von Frey filaments mice immunized...
T cell-derived opioids play a key role in the control of inflammatory pain. However, nature produced by cells is still matter debate mice. Whereas β-endorphin has been found lymphocytes using antibody-based methods, messenger RNA (mRNA) quantification shows mainly mRNA encoding for enkephalins. The objective study to elucidate responsible analgesia and clarify discrepancy results at protein genetic levels. CD4+ were isolated from wild-type enkephalin-deficient enkephalin was quantified...
Various authors have suggested similarities between tool use in early hominins and chimpanzees. This has been particularly evident studies of nut-cracking which is considered to be the most complex skill exhibited by wild apes, also interpreted as a precursor more stone-flaking abilities. It argued that there no major qualitative difference what chimpanzee does when he cracks nut did they detached flake from core. In this paper, differences skills involved are explored through an...
Sensory neurons expressing the GPCR Mrgprd mediate effects of a bioactive lipid to cause abdominal pain.
Objectives Clinical studies revealed that early-life adverse events contribute to the development of IBS in adulthood. The aim our study was investigate relationship between prenatal stress (PS), gut microbiota and visceral hypersensitivity with a focus on bacterial lipopeptides containing γ-aminobutyric acid (GABA). Design We developed model PS mice evaluated, adult offspring, colorectal distension (CRD), colon inflammation, barrier function taxonomy. quantified production GABA by mass...