A5036349502- Gastrointestinal motility and disorders
- Adenosine and Purinergic Signaling
- Gastroesophageal reflux and treatments
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Pediatric Pain Management Techniques
- Neural dynamics and brain function
- Inflammatory Bowel Disease
- Neuropeptides and Animal Physiology
- Pharmacological Effects of Natural Compounds
- Inflammation biomarkers and pathways
- Pain Mechanisms and Treatments
- Endometriosis Research and Treatment
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Intestinal and Peritoneal Adhesions
- Ion Channels and Receptors
- Diet and metabolism studies
- Restless Legs Syndrome Research
- Neuroendocrine Tumor Research Advances
- Dermatology and Skin Diseases
- Vagus Nerve Stimulation Research
Queen Mary University of London
2014-2024
VA San Diego Healthcare System
2023
University of California, San Diego
2022-2023
NaV1.9 regulates normal colonic afferent mechanosensation and is required for hypersensitivity to noxious inflammatory mediators those derived from bowel disease tissues. Chronic visceral pain affects millions of individuals worldwide remains poorly understood, with current therapeutic options constrained by gastrointestinal adverse effects. Visceral strongly associated inflammation distension the gut. Here we report that voltage-gated sodium channel subtype expressed in half gut-projecting...
Activation of visceral nociceptors by inflammatory mediators contributes to hypersensitivity and abdominal pain associated with many gastrointestinal disorders. Purine pyrimidine nucleotides (e.g., ATP UTP) are strongly implicated in this process following their release from epithelial cells during mechanical stimulation the gut, immune inflammation. Actions mediated through both ionotropic P2X receptors metabotropic P2Y receptors. receptor activation causes excitation afferents; however,...
Abstract Visceral pain is a leading cause of morbidity in inflammatory bowel disease (IBD), contributing significantly to reduced quality life. Currently available analgesics often lack efficacy or have intolerable side effects, driving the need for more complete understanding mechanisms causing pain. Whole transcriptome gene expression analysis was performed by bulk RNA sequencing colonic biopsies from patients with ulcerative colitis (UC) and Crohn's (CD) reporting abdominal compared...
Sensory neurons expressing the GPCR Mrgprd mediate effects of a bioactive lipid to cause abdominal pain.
The ability to sense visceral pain during appendicitis is diminished with age leading delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined nociception aged mouse human tissue. Inflamed noninflamed appendixes were collected from consenting patients undergoing surgery for treatment or bowel cancer. Supernatants generated by incubating samples buffer used stimulate multiunit activity intestinal preparations, single-unit...
The orbitofrontal cortex (OFC) is essential for decision making, and functional disruptions within the OFC are evident in schizophrenia. Postnatal phencyclidine (PCP) administration rats a neurodevelopmental manipulation that induces schizophrenia-relevant cognitive impairments. We aimed to determine whether manipulating glutamate cell activity could ameliorate postnatal PCP-induced deficits making.
Background: The activation of pain sensing nerves (nociceptors), which innervate the gut, by mediators released from inflamed bowel is thought to be a principal cause in Crohn's disease. Our current understanding this process limited, and further investigation needed provide insight into mechanisms nociception disease, can then targeted relieve abdominal pain. To address this, we have developed an experimental approach study visceral colitis comparing transcript expression patient biopsy...
Abstract Objective Visceral pain is a leading cause of morbidity in inflammatory bowel disease (IBD), contributing significantly to reduced quality life. Currently available analgesics often lack efficacy or have intolerable side-effects, driving the need for more complete understanding mechanisms causing pain. Methods Whole transcriptome gene expression analysis was performed by bulk RNA sequencing colonic biopsies from patients with ulcerative colitis (UC) and Crohn’s (CD) reporting...