A5042206717- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Surgical Treatments
- Pelvic floor disorders treatments
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Cancer survivorship and care
- Antenna Design and Analysis
- Hospital Admissions and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Healthcare Operations and Scheduling Optimization
- Hemodynamic Monitoring and Therapy
- Wireless Body Area Networks
- Hernia repair and management
- Trauma and Emergency Care Studies
- Colorectal Cancer Screening and Detection
- Optical Imaging and Spectroscopy Techniques
- Palliative Care and End-of-Life Issues
- Colorectal and Anal Carcinomas
- Healthcare Policy and Management
- Global Health and Surgery
- Abdominal Surgery and Complications
- Frailty in Older Adults
- Cancer Treatment and Pharmacology
- Complementary and Alternative Medicine Studies
- Diversity and Career in Medicine
Barts Health NHS Trust
2015-2024
Royal London Hospital
2015-2024
Queen Mary University of London
2015-2024
University of Birmingham
2020-2023
NIHR Birmingham Biomedical Research Centre
2021-2023
ESCP Business School
2023
ESCP Business School
2023
National University of Avellaneda
2023
Institut de Virologie
2020-2021
Countess of Chester Hospital NHS Foundation Trust
2021
Abstract Background Prevalence of colorectal cancer (CRC) in the British Bangladeshi population (BAN) is low compared to Caucasians (CAU). Genetic background may influence mutations and disease features. Methods We characterized clinicopathological features BAN CRCs interrogated their genomes using mutation profiling high-density single nucleotide polymorphism (SNP) arrays findings CAU CRCs. Results Age onset CRC was significantly lower than for patients (p=3.0 x 10 -5 ) this difference not...
To describe characteristics, presentation, time to diagnosis and diagnostic findings of patients with intestinal tuberculosis (ITB) in a low-burden country.Retrospective study 61 consecutive ITB diagnosed between 2008 2014 at large East London hospital.Forty sixty-one were male. Mean age was 34.6 years. 93% born abroad, mostly from TB-endemic areas (Indian subcontinent: 88%, Africa: 9%). 25% had concomitant pulmonary TB. Median symptom onset 13 weeks (IQR 3-26 weeks). Ten initially treated...
Activation of visceral nociceptors by inflammatory mediators contributes to hypersensitivity and abdominal pain associated with many gastrointestinal disorders. Purine pyrimidine nucleotides (e.g., ATP UTP) are strongly implicated in this process following their release from epithelial cells during mechanical stimulation the gut, immune inflammation. Actions mediated through both ionotropic P2X receptors metabotropic P2Y receptors. receptor activation causes excitation afferents; however,...
<h2>Summary</h2><h3>Background</h3> Whole-body MRI (WB-MRI) could be an alternative to multimodality staging of colorectal cancer, but its diagnostic accuracy, effect on times, number tests needed, cost, and treatment decisions are unknown. We aimed prospectively compare the accuracy efficiency WB-MRI-based pathways with standard in cancer. <h3>Methods</h3> The Streamline C trial was a prospective, multicentre done 16 hospitals England. Eligible patients were 18 years or older, newly...
<h2>Summary</h2><h3>Background</h3> Whole-body magnetic resonance imaging (WB-MRI) could be an alternative to multi-modality staging of non-small-cell lung cancer (NSCLC), but its diagnostic accuracy, effect on times, number tests needed, cost, and treatment decisions are unknown. We aimed prospectively compare the accuracy efficiency WB-MRI-based pathways with standard in NSCLC. <h3>Methods</h3> The Streamline L trial was a prospective, multicentre done 16 hospitals England. Eligible...
Percutaneous tibial nerve stimulation (PTNS) is increasingly being used as a treatment for faecal incontinence (FI). The evidence its efficacy limited to few studies involving small numbers of patients. aim the study was assess PTNS in patients with urge, passive and mixed FI.A prospective cohort 100 FI studied. Continence scores were determined before following 12 sessions using validated questionnaire [Cleveland Clinic Florida (CCF)-FI score]. deferment time average number weekly episodes...
Solid tumours have oxygen gradients and areas of near almost total anoxia. Hypoxia reduces sensitivity to 5-fluorouracil (5-FU)-chemotherapy for colorectal cancer (CRC). MicroRNAs (miRNAs) are hypoxia sensors were altered consistently in six CRC cell lines (colon cancer: DLD-1, HCT116 HT29; rectal HT55, SW837 VACO4S) maintained (1 0.2% oxygen) compared with normoxia (20.9%). also showed amino acid metabolism hypoxia-responsive miRNAs predicted target genes four pathways: beta-alanine;...
This study presents the development of a grey-box modelling approach and fuzzy logic control for real time trajectory an experimental four degree-of-freedom Leader-Follower Robot (LFR) manipulator system using hybrid optimisation algorithm, known as Grey Wolf Optimiser (GWO) - Whale Optimisation Algorithm (WOA). The has advantages in achieving accurate model LFR system, together with better tracking performance. In first instance, white box is formed by dynamics follower Euler-Lagrange...
Objective The development of effective visceral analgesics free deleterious gut-specific side effects is a priority. We aimed to develop reproducible methodology study nociception in human tissue that could aid future target identification and drug evaluation. Design Electrophysiological (single unit) responses afferents mechanical (von Frey hair (VFH) stretch) chemical (bradykinin ATP) stimuli were examined. Thus, serosal (putative nociceptors) used investigate the effect tegaserod,...
Abstract Background Controversy has surrounded the technique of circular stapled anopexy since an isolated report a high incidence persistent postdefaecation pain following procedure. The characteristics, clinical course and management this complication have not been described. Methods Within ongoing multicentre randomized trial comparing with closed haemorrhoidectomy, 77 patients underwent anopexy. Follow-up was at 6, 12, 24 48 weeks. Patients transanal ultrasonography, anal...
<h3>Objective:</h3> Unlike excisional haemorrhoidectomy, stapled anopexy (SA), which does not involve radical excision, has theoretical advantages, thus offering potential patient benefits. We compared the clinical efficacy, safety and acceptability of SA, with closed haemorrhoidectomy (CH). <h3>Patients methods:</h3> 182 patients symptomatic haemorrhoids (grades II, III, IV) were randomly assigned to receive SA or CH followed for up 1 year (6, 12, 24, 48 weeks) after operation....
Objective To determine if human colonic neuromuscular functions decline with increasing age. Design Looking for non-specific changes in function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (cholinergic/nitrergic) contractions/relaxations ex vivo muscle strips ascending and descending colon, aged 35–91 years (macroscopically normal tissue; 239 patients undergoing cancer resection). Then, understand mechanisms change, numbers phenotype...
Abstract Background Two million people in the UK are living with or beyond cancer and a third of them report poor quality life (QoL) due to problems such as fatigue, fear recurrence, concerns about returning work. We aimed develop evaluate an intervention based on acceptance commitment therapy (ACT), suited address survivors improving their QoL. also recognise importance exercise vocational activity QoL therefore will integrate options for physical return work/vocational support, thus ACT...