A5029134034- Respiratory and Cough-Related Research
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Patient Satisfaction in Healthcare
- Urinary Tract Infections Management
- Respiratory viral infections research
- Otolaryngology and Infectious Diseases
- Blood Pressure and Hypertension Studies
- Musculoskeletal pain and rehabilitation
- Digital Mental Health Interventions
- Patient-Provider Communication in Healthcare
- Asthma and respiratory diseases
- Ear Surgery and Otitis Media
- Complementary and Alternative Medicine Studies
- Health Systems, Economic Evaluations, Quality of Life
- Pediatric health and respiratory diseases
- Mobile Health and mHealth Applications
- Healthcare Systems and Technology
- COVID-19 and Mental Health
- Behavioral Health and Interventions
- Pelvic floor disorders treatments
- Primary Care and Health Outcomes
- Bacterial Identification and Susceptibility Testing
- Empathy and Medical Education
University of Southampton
2016-2025
NIHR Southampton Biomedical Research Centre
2020-2025
University of Cambridge
2003-2024
Primary Health Care
2012-2024
Keele University
2013-2024
The London College
2023-2024
University College London
2016-2024
University of Manchester
2023-2024
University of Leicester
2012-2024
Drug Safety Research Unit
2012-2024
<h3>Abstract</h3> <b>Objective:</b> To measure patients9 perceptions of patient centredness and the relation these to outcomes. <b>Design:</b> Observational study using questionnaires. <b>Setting:</b> Three general practices. <b>Participants:</b> 865 consecutive patients attending <b>Main outcome measures:</b> Patients9 enablement, satisfaction, burden symptoms. <b>Results:</b> Factor analysis identified five components. These were communication partnership (a sympathetic doctor interested...
<h3>Abstract</h3> <b>Objective:</b> To identify patient9s preferences for patient centred consultation in general practice. <b>Design:</b> Questionnaire study. <b>Setting:</b> Consecutive patients the waiting room of three doctors9 surgeries. <b>Main outcome measures:</b> Key domains centredness from perspective. Predictors centredness, a prescription, and examination. <b>Results:</b> 865 participated: 824 (95%) returned pre-consultation questionnaire were similar demographic characteristic...
<h3>Background</h3> In 2007, ESAC (http://www.esac.ua.ac.be) published a set of 12 valid drug-specific quality indicators for outpatient antibiotic use in Europe. this study, the authors aimed to develop evidence-based disease-specific prescribing <h3>Methods</h3> Two meetings were convened produce list which conform internationally agreed recommendations, building on similar development indicators, and collaboration with CHAMP HAPPY AUDIT. 62 experts asked complete two scoring rounds...
<h3>Abstract</h3> <b>Objective:</b> To assess the medicalising effect of prescribing antibiotics for sore throat. <b>Setting:</b> 11 general practices in England. <b>Design:</b> Randomised trial three approaches to throat: a 10 day prescription antibiotics, no or delayed if throat had not started settle after days. <b>Patients:</b> 716 patients aged 4 and over with an abnormal physical sign: 84% tonsillitis pharyngitis. <b>Outcome measures:</b> Number rate making first return throat,...
Self-monitoring of blood pressure with self-titration antihypertensives (self-management) results in lower patients hypertension, but there are no data about high-risk groups.To determine the effect self-monitoring antihypertensive medication compared usual care on systolic among cardiovascular disease, diabetes, or chronic kidney disease.A primary care, unblinded, randomized clinical trial involving 552 who were aged at least 35 years a history stroke, coronary heart disease and baseline...
To describe variation in antibiotic prescribing for acute cough contrasting European settings and the impact on recovery.Cross sectional observational study with clinicians from 14 primary care research networks 13 countries who recorded symptoms presentation management. Patients followed up 28 days patient diaries.Primary care.Adults a new or worsening clinical suggestive of lower respiratory tract infection.Prescribing antibiotics by total symptom severity scores over time.3402 patients...
Objectives Overutilisation of antibiotics may contribute to the emergence antimicrobial drug resistance, a growing international concern. This study aimed analyse performance UK general practices with respect antibiotic prescribing for respiratory tract infections (RTIs) among young and middle-aged adults. Setting Data are reported 568 contributing Clinical Practice Research Datalink. Participants were adults aged 18–59 years. Consultations identified acute upper RTIs including colds, cough,...
Lower-respiratory-tract infection is one of the most common acute illnesses managed in primary care. Few placebo-controlled studies antibiotics have been done, and overall effectiveness (particularly subgroups such as older people) debated. We aimed to compare benefits harms amoxicillin for lower-respiratory-tract with those placebo both patients aged 60 years or older.Patients than 18 infections (cough ≤28 days' duration) whom pneumonia was not suspected were randomly assigned (1:1) either...
<b>Objectives</b> To quantify the diagnostic accuracy of selected inflammatory markers in addition to symptoms and signs for predicting pneumonia derive a tool. <b>Design</b> Diagnostic study performed between 2007 2010. Participants had their history taken, underwent physical examination measurement C reactive protein (CRP) procalcitonin venous blood on day they first consulted, chest radiography within seven days. <b>Setting</b> Primary care centres 12 European countries....
Objective To evaluate the clinical effectiveness of two modes cognitive–behavioural therapy (CBT) for IBS compared with treatment as usual (TAU) in refractory IBS. Design A three-arm randomised controlled trial assessing telephone-delivered CBT (TCBT), web-based (WCBT) minimal therapist support, and TAU. Blinding participants therapists was not possible. Chief investigator, assessors statisticians were blinded. Participants adults (clinically significant symptoms ≥12 months despite...
Abstract Objective The HOME BP (Home and Online Management Evaluation of Blood Pressure) trial aimed to test a digital intervention for hypertension management in primary care by combining self-monitoring blood pressure with guided self-management. Design Unmasked randomised controlled automated ascertainment endpoint. Setting 76 general practices the United Kingdom. Participants 622 people treated but poorly (>140/90 mm Hg) access internet. Interventions were using minimisation algorithm...
Abstract Viral clearance, antibody response and the mutagenic effect of molnupiravir has not been elucidated in at-risk populations. Non-hospitalised participants within 5 days SARS-CoV-2 symptoms randomised to receive (n = 253) or Usual Care 324) were recruited study viral dynamics on whole genome sequence from 1437 genomes. Molnupiravir accelerates load decline, but virus is detectable by Day most cases. At 14 (9 post-treatment), associated with significantly higher persistence lower...
Background Type 2 diabetes is common, costly and often goes unrecognised for many years. When patients are diagnosed, the majority exhibit associated tissue damage or established cardiovascular risk. Evidence accumulating that earlier detection management of related metabolic abnormalities may be beneficial. We aimed to develop evaluate a score based on routinely collected information identify people at risk having undetected diabetes. Methods A population-based sample 1077 people, aged 40...
<h3>Abstract</h3> <b>Objective:</b> To compare immediate with delayed prescribing of antibiotics for acute otitis media. <b>Design:</b> Open randomised controlled trial. <b>Setting:</b> General practices in south west England. <b>Participants:</b> 315 children aged between 6 months and 10 years presenting <b>Interventions:</b> Two treatment strategies, supported by standardised advice sheets—immediate or (antibiotic prescription to be collected at parents9 discretion after 72 hours if child...
<h3>Abstract</h3> <b>Objective:</b> To assess three prescribing strategies for sore throat. <b>Design:</b> Randomised follow up study. <b>Setting:</b> 11 general practices in the South and West region. <b>Subjects:</b> 716 patients aged 4 years over with throat an abnormal physical sign throat; 84% had tonsillitis or pharyngitis. Patients were randomised to groups: prescription antibiotics 10 days (group 1, 246 patients); no 2, 230 if symptoms not starting settle after 3; 238 patients)....