A5090603814- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
- Cardiac Health and Mental Health
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Mechanical Circulatory Support Devices
- Genetic Associations and Epidemiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- Vitamin C and Antioxidants Research
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- Healthcare Technology and Patient Monitoring
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
- Sulfur Compounds in Biology
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Cardiovascular Health and Risk Factors
- Renin-Angiotensin System Studies
Emory University
2010-2023
Atlanta VA Health Care System
2019
Veterans Health Administration
2004-2018
Atlanta VA Medical Center
2006-2017
Atlanta Medical Center
2001-2017
University College London
2014-2017
Florida International University
2014-2017
National and Kapodistrian University of Athens
2017
Copenhagen University Hospital
2017
MedStar Heart & Vascular Institute
2017
Superoxide anion formation is vital to the microbicidal activity of phagocytes. Recently, however, there accumulating evidence that it also involved in cell growth vascular smooth muscle cells (VSMCs). We have shown hypertrophic agent angiotensin II stimulates superoxide production by activating membrane-bound NADH/NADPH oxidase and inhibition this attenuates hypertrophy. However, molecular identity VSMCs unknown. recently cloned cytochrome b558 alpha-subunit, p22(phox) (one key electron...
Abstract —Recent evidence suggests that oxidative mechanisms may be involved in vascular smooth muscle cell (VSMC) hypertrophy. We previously showed angiotensin II (Ang II) increases superoxide production by activating an NADH/NADPH oxidase, which contributes to In this study, we determined whether Ang stimulation of oxidase results H 2 O studying the effects on intracellular generation, dismutase and catalase activity, (100 nmol/L) significantly increased levels at 4 hours. Neither activity...
Free radical scavengers have failed to improve patient outcomes, promoting the concept that clinically important oxidative stress may be mediated by alternative mechanisms. We sought examine association of emerging aminothiol markers nonfree with clinical outcomes.Plasma levels reduced (cysteine and glutathione) oxidized (cystine glutathione disulphide) aminothiols were quantified high performance liquid chromatography in 1411 patients undergoing coronary angiography (mean age 63 years, male...
Background Young women with coronary heart disease have high rates of depression and a higher risk adverse events than men similar age. Whether has prognostic value in this group older is not known. Our objective was to assess whether young associated artery ( CAD ) outcomes compared similarly aged women. Methods Results We examined 3237 patients undergoing angiography for evaluation followed them 2.9 years (median). Depressive symptoms were assessed the Patient Health Questionnaire PHQ )‐9,...
Rationale: Low circulating progenitor cell numbers and activity may reflect impaired intrinsic regenerative/reparative potential, but it remains uncertain whether this translates into a worse prognosis. Objectives: To investigate low of cells associate with greater risk mortality in population at high cardiovascular risk. Methods Results: Patients undergoing coronary angiography were recruited 2 cohorts (1, n=502 2, n=403) over separate time periods. Progenitor enumerated by flow cytometry...
Oxidative stress contributes to the pathogenesis of atherosclerosis. p22 phox -based NAD(P)H oxidases exist in vessel wall, acting as important superoxide-generating systems vasculature. Some studies have identified reduced atherosclerosis presence C242T CYBA polymorphism, whereas others not. Because vascular is identical neutrophil , we studied association between C242T, A640G, and −930 A/G polymorphisms quantity superoxide produced from neutrophils isolated healthy adults determine if...
Heart failure (HF) is associated with reduced cardiac Na + channel (SCN5A) current. We hypothesized that abnormal transcriptional regulation of this ion during HF could help explain the Using human hearts explanted at transplantation, we have identified 3 C-terminal SCN5A mRNA splicing variants predicted to result in truncated, nonfunctional channels. As compared normal hearts, ventricles showed an upregulation 2 and a downregulation full-length transcript such E28A represented only 48.5% (...
Background Mental stress–induced myocardial ischemia ( MSIMI ) is associated with adverse prognosis in patients coronary artery disease CAD ), yet the mechanisms underlying this phenomenon remain unclear. We hypothesized that compared exercise/pharmacological PSIMI secondary to atherosclerotic burden of , primarily due vasomotor changes. Methods and Results Patients angiographically documented underwent 99m Tc‐sestamibi perfusion imaging at rest following both mental physical stress testing,...
We tested the hypothesis that 9p21 risk locus promotes atherosclerosis by examining association between rs10757278 and coronary artery disease (CAD) severity progression determined semi-quantitative angiographic scores. The single nucleotide polymorphism (SNP) was genotyped as marker for in 2334 Caucasian patients undergoing cardiac catheterization (mean age 63, male 67%). Angiographic CAD assessed using two scoring systems with one estimating (Gensini) other extent (Sullivan). A subset of...
Production of superoxide (O 2 ·− ) by NADPH oxidases contributes to the development hypertension and atherosclerosis. Factors responsible for activation are not well understood; interestingly, cardiovascular disease is associated with both altered oxidase activity age-associated mitochondrial dysfunction. We hypothesized that dysfunction may contribute oxidase. The effect inhibitors on phagocytic in human lymphoblasts whole blood was measured at basal state upon PKC-dependent stimulation PMA...
<i>Objective</i>. This paper illustrates the evolution of our knowledge arterial pulse from ancient times to present. Several techniques for evaluation throughout history are discussed. <i>Methods</i>. Using databases including Worldcat, Pubmed, and Emory University Libraries' Catalogue, significance is discussed in three historical eras medicine: ancient, medieval, modern. <i>Summary</i>. Techniques used over time analyze its characteristics have advanced simple by touch complex...
Rationale: We investigated aging of human endogenous reparative capacity and aimed to clarify whether it is affected by presence cardiovascular disease or its risk factors (RFs). Objective: Circulating progenitor cell (PC) levels reflect regenerative potential. The effect on PC healthy compared with RFs (CVD) unknown. examined exposure RF CVD leads an accelerated decline in circulating increasing age. Methods Results: In 2792 adult subjects, 498 were free (smoking, diabetes mellitus,...
Genome-wide association studies have identified multiple variants associating with coronary artery disease (CAD) and myocardial infarction (MI). Whether a combined genetic risk score (GRS) is associated prevalent incident MI in high-risk subjects remains to be established.In undergoing cardiac catheterization (n=2597), we cases history of onset at age <70 years controls ≥70 without prior followed them for death. Genotyping was performed 11 established CAD/MI variants, GRS calculated based on...
Oxidative stress contributes to the development of pulmonary hypertension in experimental models, but this association humans is unknown. We investigated relationship between artery systolic pressure measured by echocardiography and plasma aminothiol oxidative markers, with hypothesis that will be higher those hypertension. A group 347 patients aged 65±12 years from Emory Cardiovascular Biobank underwent echocardiographic assessment left ventricular ejection fraction pressure. Plasma...
Background Regional cerebral oxygen saturation ( rSO 2 ) as assessed by near infrared frontal spectroscopy decreases in circulatory arrest and increases with high‐quality cardiopulmonary resuscitation. We hypothesized that higher during resuscitation after return of spontaneous circulation ROSC would predict survival to discharge neurological recovery. Methods Results This prospective case series included patients experiencing in‐hospital cardiac arrest. Cerebral oximetry was recorded...
Previously, we showed that angiotensin II stimulation of the NADH/NADPH oxidase is involved in hypertrophy cultured vascular smooth muscle cells (VSMC). Here, examine pathways leading to activation, and demonstrate arachidonic acid metabolites mediate by activating p22phox-based oxidase. Angiotensin stimulates phospholipase A2, releasing acid, which activity vitro. When metabolism blocked with 5,8,11,14- eicosatetraynoic (ETYA) or nordihydroguaiaretic (NDGA), decreases 80 ± 10%. In VSMC...