A5028646703- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Chronic Disease Management Strategies
- Food Allergy and Anaphylaxis Research
- Acne and Rosacea Treatments and Effects
- Complementary and Alternative Medicine Studies
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Healthcare innovation and challenges
- Health Systems, Economic Evaluations, Quality of Life
- Skin Protection and Aging
- Geriatric Care and Nursing Homes
- melanin and skin pigmentation
- Antibiotic Use and Resistance
- Interprofessional Education and Collaboration
- Palliative Care and End-of-Life Issues
- Health disparities and outcomes
- Bacterial Identification and Susceptibility Testing
- Health, psychology, and well-being
- Streptococcal Infections and Treatments
- Primary Care and Health Outcomes
- Dermatological diseases and infestations
- Pharmaceutical Practices and Patient Outcomes
- Reproductive tract infections research
- Antimicrobial Resistance in Staphylococcus
University of Southampton
2016-2025
NIHR Southampton Biomedical Research Centre
2020-2025
Primary Health Care
2018-2024
Drug Safety Research Unit
2011-2021
NIHR Evaluation Trials and Studies Coordinating Centre
2020
National Institute for Health Research
2020
Designability
2015
Broadmoor Hospital
2015
University of Edinburgh
1997-2007
University of Dundee
2005-2006
Abstract Objective To assess the effectiveness of oral spironolactone for acne vulgaris in adult women. Design Pragmatic, multicentre, phase 3, double blind, randomised controlled trial. Setting Primary and secondary healthcare, advertising community on social media England Wales. Participants Women (≥18 years) with facial at least six months, judged to warrant antibiotics. Interventions were randomly assigned (1:1) either 50 mg/day or matched placebo until week six, increasing 100 24. could...
Abstract Aim To explore parents and carers' experiences of barriers facilitators to treatment adherence in childhood eczema Background Childhood is common causes significant impact on quality life for children their families, particularly due sleep disturbance itch. Non‐adherence application topical treatments the main cause failure. Design Qualitative interview study. Methods interviews were carried out with 31 carers from 28 families eczema. Participants recruited through primary care...
Abstract Objectives To determine the clinical effectiveness and cost of including emollient bath additives in management eczema children. Design Pragmatic randomised open label superiority trial with two parallel groups. Setting 96 general practices Wales western southern England. Participants 483 children aged 1 to 11 years, fulfilling UK diagnostic criteria for atopic dermatitis. Children very mild who bathed less than once weekly were excluded. Interventions intervention group prescribed...
The value and importance of qualitative research Patient Public Involvement (PPI) for developing complex health interventions is widely recognised. However, there often confusion between the two, with researchers relying on just one these approaches, rather than using two alongside another.The Person-Based Approach (PBA) to health-related behaviour change adapts integrates methods from user-centred design research. PBA involves at multiple stages ensure they are acceptable, feasible,...
To our knowledge, there are no trials comparing emollients commonly used for childhood eczema. We aimed to compare the clinical effectiveness and safety of four main emollient types: lotions, creams, gels, ointments.We did a pragmatic, individually randomised, parallel group, phase 4 superiority trial in 77 general practice surgeries England. Children aged between 6 months 12 years with eczema (Patient Orientated Eczema Measure [POEM] score >2) were randomly assigned (1:1:1:1; stratified by...
To determine the effectiveness of two online behavioural interventions, one for parents and carers young people, to support eczema self-management.Two independent, pragmatic, parallel group, unmasked, randomised controlled trials.98 general practices in England.Parents children (0-12 years) with (trial 1) people (13-25 2), excluding inactive or very mild (≤5 on POEM, Patient-Oriented Eczema Measure).Participants were (1:1) using software receive usual care an (www.EczemaCareOnline.org.uk)...
Heavy menstrual bleeding is a common symptom amongst women of reproductive age, yet questions remain about why some experience this as problem while others do not. We investigated the concerns who reported heavy on questionnaire.A cross-sectional postal survey and qualitative interviews were carried out community-based sample in Lothian, Scotland. 906 aged 25 to 44 or very periods response 2833 registered with 19 general practices. Amongst those had bleeding, analysis was responses free text...
Childhood eczema causes significant impact on quality of life for some families, yet non-concordance with treatment is common.To explore parents' and carers' views childhood its treatment.Qualitative interview study in primary care the south England.Carers children aged ≤5 years a recorded diagnosis eczema, who reported that was still problem, were invited to participate. Thirty-one parents interviewed from 28 families.Many expressed frustration both medical prescribed treatments. They felt...
Background Conservative kidney management (CKM) is recognised as an alternative to dialysis for a significant number of older adults with multimorbid stage 5 chronic disease (CKD5). However, little known about the way CKM delivered or how it perceived. Aim To determine practice patterns patients CKD5, inform service development and future research. Objectives (1) describe differences between renal units in extent nature CKM, (2) explore decisions are made treatment options (3) clinicians’...
Objectives To compare the effectiveness and safety of naproxen low-dose colchicine for treating gout flares in primary care. Methods This was a multicentre open-label randomised trial. Adults with flare recruited from 100 general practices were equally to 750 mg immediately then 250 every 8 hours 7 days or 500 mcg three times per day 4 days. The outcome change worst pain intensity last 24 (0–10 Numeric Rating Scale) baseline measured daily over first days: mean compared between groups 1–7 by...
<h3>PURPOSE</h3> C-reactive-protein (CRP) is useful for diagnosis of lower respiratory tract infections (RTIs). A large international trial documented that Internet-based training in CRP point-of-care testing, enhanced communication skills, or both reduced antibiotic prescribing at 3 months, with risk ratios (RRs) 0.68, 0.53, 0.38, respectively. We report the longer-term impact this trial. <h3>METHODS</h3> total 246 general practices 6 countries were cluster-randomized to usual care, on...
Background Growing demand from an increasingly ageing population with multimorbidity has resulted in complex health and social care needs requiring more integrated services. Integrating primary services could utilise resources efficiently, improve experiences for patients, their families, carers. There is limited evidence on progress including key barriers to drivers of integration inform large-scale national change. Aim To elicit stakeholder views services, highlight opportunities...
<ns3:p>Background A priority setting partnership for eczema (syn atopic eczema, dermatitis) has identified that bathing frequency is a key area of patient interest. However, there are nolarge, high-quality randomised controlled trials (RCTs) investigating this. The Rapid Eczema Trials project novel programme research aims to deliver multiple online RCTs, using citizen science approach. This involves working with members the public co-design and conduct studies answer questions importance...
Eczema Care Online ( www.EczemaCareOnline.org.uk/ ) is an online self-management toolkit which includes tailored content for young people (13-25 years) and parents of children that have eczema (0-12 years). Testing in two randomised controlled trials has shown it easy to use, cost effective offers a sustained improvement symptoms. Implementing outside funded research study ensuring reaches those will most benefit from now key challenge. This paper describes the lessons learnt developing...