A5058081230- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal pain and rehabilitation
- Healthcare Policy and Management
- Antibiotic Use and Resistance
- Orthopedic Surgery and Rehabilitation
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Nerve Disorders
- Clinical practice guidelines implementation
- Primary Care and Health Outcomes
- Global Maternal and Child Health
- Delphi Technique in Research
- Patient Satisfaction in Healthcare
- Pneumonia and Respiratory Infections
- Shoulder Injury and Treatment
- Emergency and Acute Care Studies
- Respiratory and Cough-Related Research
- Healthcare Systems and Reforms
- Nosocomial Infections in ICU
- Global Health Care Issues
- Hernia repair and management
- Maternal and fetal healthcare
- Sexual Differentiation and Disorders
- Pharmaceutical Economics and Policy
- Enhanced Recovery After Surgery
- Efficiency Analysis Using DEA
University of Birmingham
2015-2024
National Institute for Health Research
2024
University College Birmingham
2024
University College London
2023
Foundation for Growth Science
2023
Keele University
2014-2022
Versus Arthritis
2020-2022
Institute of Health Economics
2020
University of Nottingham
2020
Vancouver Coastal Health
2014
Abstract Background Antimicrobial resistance (AMR) poses a colossal threat to global health and incurs high economic costs society. Economic evaluations of antimicrobials interventions such as diagnostics vaccines that affect their consumption rarely include the AMR, resulting in sub-optimal policy recommendations. We estimate cost AMR per antibiotic consumed, stratified by drug class national income level. Methods The model is comprised three components: correlation coefficients between...
BackgroundTo our knowledge, the comparative effectiveness of commonly used conservative treatments for carpal tunnel syndrome has not been evaluated previously in primary care. We aimed to compare clinical and cost-effectiveness night splints with a corticosteroid injection regards reducing symptoms improving hand function patients mild or moderate syndrome.MethodsWe did this randomised, open-label, pragmatic trial adults (≥18 years) recruited from 25 community musculoskeletal clinics...
Point-of-care C-reactive protein (POCCRP) is a biomarker of inflammation that offers clinicians rapid POC test to guide antibiotic prescribing decisions for acute cough and lower respiratory tract infections (LRTI). However, evidence POCCRP cost-effective limited, particularly outside experimental settings.To assess the cost-effectiveness as diagnostic tool LRTI from perspective health service.Observational study presentation, management, outcomes patients with in primary care settings...
Patients with musculoskeletal pain in different body sites share common prognostic factors. Using prognosis to stratify and treatment match can be clinically cost-effective. We aimed refine validate the Keele STarT MSK Tool for stratification of patients.Tool refinement validity was tested a prospective cohort study, external examined pilot cluster randomized controlled trial (RCT). Study population comprised 2,414 adults visiting U.K. primary care back, neck, knee, shoulder or multisite...
To compare the clinical effectiveness of adding a single ultrasound guided intra-articular hip injection corticosteroid and local anaesthetic to advice education in adults with osteoarthritis.Pragmatic, three arm, parallel group, blind, randomised controlled trial.Two community musculoskeletal services England.199 aged ≥40 years osteoarthritis at least moderate pain: 67 were randomly assigned receive (best current treatment (BCT)), 66 BCT plus triamcinolone lidocaine, lidocaine.BCT alone, 40...
<h3>Background</h3> Lower respiratory tract infections (LRTIs) are a major disease burden and often treated with antibiotics. Typically, studies evaluating the use of antibiotics focus on immediate costs care, do not account for wider implications antimicrobial resistance. <h3>Aim</h3> This study sought to establish whether (principally amoxicillin) cost effective in patients LRTIs, explore taking into associated <h3>Design setting</h3> Multinational randomised double-blinded trial 2060...
There is as yet no evidence on the feasibility of implementing recommendations from National Institute Health and Care Excellence (NICE) osteoarthritis (OA) guidelines in primary care, or effect these have condition. The aim this study to determine clinical cost effectiveness a model OA consultation (MOAC), core NICE care. Secondary aims are investigate impact, acceptability MOAC intervention; develop evaluate training package for management by general practitioners (GPs) practice nurses;...
Objectives To compare the effectiveness and safety of naproxen low-dose colchicine for treating gout flares in primary care. Methods This was a multicentre open-label randomised trial. Adults with flare recruited from 100 general practices were equally to 750 mg immediately then 250 every 8 hours 7 days or 500 mcg three times per day 4 days. The outcome change worst pain intensity last 24 (0–10 Numeric Rating Scale) baseline measured daily over first days: mean compared between groups 1–7 by...
Objectives To compare the clinical effectiveness of (1) physiotherapist-led exercise versus an leaflet, and (2) ultrasound-guided subacromial corticosteroid injection unguided for pain function in (formerly impingement) syndrome (SAPS). Methods This was a single-blind 2×2 factorial randomised trial. Adults with SAPS were equally to one four treatment groups: exercise, (3) (4) leaflet. The primary outcome Shoulder Pain Disability Index (SPADI), collected at 6 weeks, 12 months compared weeks...
<h2>Summary</h2><h3>Background</h3> Surgical site infection (SSI) is a major burden on patients and health systems. This study assessed the cost-effectiveness of routine change sterile gloves instruments before abdominal wall closure to prevent SSI. <h3>Methods</h3> A decision-analytic model was built estimate average costs outcomes changing compared with current practice. Clinical data were obtained from ChEETAh trial, multicentre, cluster-randomised trial in seven low-income middle-income...
Timely detection and treatment of postpartum hemorrhage (PPH) are crucial to prevent complications or death. A calibrated blood-collection drape can help provide objective, accurate early diagnosis PPH, a bundle address delays inconsistencies in the use effective interventions. Here we conducted an economic evaluation alongside E-MOTIVE trial, international, parallel cluster-randomized trial with baseline control phase involving 210,132 women undergoing vaginal delivery across 78...
Background Ghana is implementing activities towards universal health coverage (UHC) as well the attainment of health-related Sustainable Development Goals (SDGs) by sector year 2030. Aside lack empirical forecast required healthcare facilities to achieve these mandates, workforce deficits are also a major threat. We therefore modelled needed in and translated it into year-by-year staffing requirements based on established standards. Methods Two levels modelling were used. First, predictive...
Ventilator-associated pneumonia is associated with significant morbidity, mortality and healthcare costs. Most of the cost data that are available relate to general intensive care patients in privately remunerated institutions. This study assessed managing ventilator-associated a cardiac unit National Health Service United Kingdom.Propensity-matched prospectively collected from surgical database between April 2011 December 2014 all undergoing surgery (n = 3416). Patients who were diagnosed...
Objectives. Evidence regarding the cost-effectiveness of joint protection and hand exercises for management OA is not well established. The primary aim this study to assess (cost-utility) these options. In addition, given absence consensus conduct economic evaluation alongside factorial trials, we compare different analytical methodologies.
Overprescribing of antibiotics by general practitioners (GPs) is seen as a major driver antibiotic resistance. Training in communication skills and C-reactive protein (CRP) testing both appear effective reducing such prescribing. This study assesses the cost-effectiveness (compared with usual care) of: (i) training GPs use CRP testing; (ii) skills; (iii) skills.Economic analyses [cost-utility analysis (CUA) accounting for cost resistance (CEA)] were conducted from healthcare perspective time...
SummaryBackgroundAlthough colorectal cancer is increasing in India, the cost of comprehensive treatment and its consequences for patients households are unknown. This study aimed to describe catastrophic expenditure attrition with a plan cancer.MethodsA prospective, multicentre, cohort was conducted five tertiary hospitals India from December 2020 March 2022. Consecutive new were followed-up six months. The total reported, including out-of-pocket payments (OOPP, paid by at time-of-service...
Background Osteoarthritis (OA) is the most common long-term condition managed in UK general practice. However, care suboptimal despite evidence that primary and community-based interventions can reduce OA pain disability. Objectives The overall aim was to improve management of health patients with OA. Four parallel linked workstreams aimed (1) develop a economic decision model for estimating potential cost-effective delivery population health, (2) evaluate new health-care models core...
Musculoskeletal (MSK) pain is a major cause of and disability. We previously developed prognostic tool (Start Back Tool) with demonstrated effectiveness in guiding primary care low back management by supporting decision making using matched treatments. A logical next step to determine whether stratified has benefits for broader range common MSK presentations.This study seeks determine, patients 1 the 5 most presentations (back, neck, knee, shoulder, multisite pain), involving use Keele Start...