A5041746833- Pneumonia and Respiratory Infections
- Respiratory and Cough-Related Research
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Patient Satisfaction in Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Healthcare Systems and Technology
- Emergency and Acute Care Studies
- Urinary Tract Infections Management
- Influenza Virus Research Studies
- Pediatric health and respiratory diseases
- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Respiratory Support and Mechanisms
- Patient Safety and Medication Errors
- Helicobacter pylori-related gastroenterology studies
- Nosocomial Infections in ICU
- Otolaryngology and Infectious Diseases
- Streptococcal Infections and Treatments
- Clinical Reasoning and Diagnostic Skills
- Bacterial Infections and Vaccines
- Medical Malpractice and Liability Issues
- Eosinophilic Esophagitis
- Pelvic floor disorders treatments
University Medical Center Utrecht
2016-2025
Utrecht University
2012-2025
University of Southampton
2011-2025
Veiligheids- en Gezondheidsregio Gelderland-Midden
2025
Oklahoma State University Center for Health Sciences
2012-2024
National Institute for Public Health and the Environment
2020-2022
Heidelberg University
2004-2022
University Hospital Heidelberg
2004-2022
Huisarts en Wetenschap
2006-2021
Leidsche Rijn Julius Health Centers
2020
Pneumococcal polysaccharide conjugate vaccines prevent pneumococcal disease in infants, but their efficacy against community-acquired pneumonia adults 65 years of age or older is unknown.In a randomized, double-blind, placebo-controlled trial involving 84,496 older, we evaluated the 13-valent vaccine (PCV13) preventing first episodes vaccine-type strains pneumonia, nonbacteremic and noninvasive invasive disease. Standard laboratory methods serotype-specific urinary antigen detection assay...
<h3>Background</h3> In 2007, ESAC (http://www.esac.ua.ac.be) published a set of 12 valid drug-specific quality indicators for outpatient antibiotic use in Europe. this study, the authors aimed to develop evidence-based disease-specific prescribing <h3>Methods</h3> Two meetings were convened produce list which conform internationally agreed recommendations, building on similar development indicators, and collaboration with CHAMP HAPPY AUDIT. 62 experts asked complete two scoring rounds...
To describe variation in antibiotic prescribing for acute cough contrasting European settings and the impact on recovery.Cross sectional observational study with clinicians from 14 primary care research networks 13 countries who recorded symptoms presentation management. Patients followed up 28 days patient diaries.Primary care.Adults a new or worsening clinical suggestive of lower respiratory tract infection.Prescribing antibiotics by total symptom severity scores over time.3402 patients...
Lower-respiratory-tract infection is one of the most common acute illnesses managed in primary care. Few placebo-controlled studies antibiotics have been done, and overall effectiveness (particularly subgroups such as older people) debated. We aimed to compare benefits harms amoxicillin for lower-respiratory-tract with those placebo both patients aged 60 years or older.Patients than 18 infections (cough ≤28 days' duration) whom pneumonia was not suspected were randomly assigned (1:1) either...
<b>Objectives</b> To quantify the diagnostic accuracy of selected inflammatory markers in addition to symptoms and signs for predicting pneumonia derive a tool. <b>Design</b> Diagnostic study performed between 2007 2010. Participants had their history taken, underwent physical examination measurement C reactive protein (CRP) procalcitonin venous blood on day they first consulted, chest radiography within seven days. <b>Setting</b> Primary care centres 12 European countries....
ScopeThe Dutch Working Party on Antibiotic Policy constituted a multidisciplinary expert committee to provide evidence-based recommendation for the use of antibacterial therapy in hospitalized adults with respiratory infection and suspected or proven 2019 Coronavirus disease (COVID-19).MethodsWe performed literature search answer four key questions. The graded evidence developed recommendations by using Grading Recommendations Assessment, Development, Evaluation methodology.Questions...
Primary care has a crucial role in responding to the COVID-19 pandemic as first point of patient and gatekeeper secondary care. Qualitative studies exploring experiences healthcare professionals during have mainly focused on care.To gain an understanding European primary (PCPs) working peak pandemic.An exploratory qualitative study, using semi-structured interviews England, Belgium, Netherlands, Ireland, Germany, Poland, Greece, Sweden, between April July 2020.Interviews were audiorecorded,...
<h3>Background and objective:</h3> Indicators to measure the quality of healthcare are increasingly used by professionals policy makers. In context increasing antimicrobial resistance, this study aimed develop valid drug-specific indicators for outpatient antibiotic use in Europe, derived from European Surveillance Antimicrobial Consumption (ESAC) data. <h3>Methods:</h3> 27 experts (15 countries), a Science Foundation workshop, built on expertise within Drug Utilisation Research Group,...
<h3>Abstract</h3> <b>Objectives</b> To assess the effectiveness of a multiple intervention aimed at reducing antibiotic prescription rates for symptoms respiratory tract in primary care. <b>Design</b> Randomised controlled trial. <b>Subjects</b> Twelve peer review groups including 100 general practitioners with their collaborating pharmacists region Utrecht, Netherlands. <b>Intervention</b> The consisted group education meetings, consensus procedure on indication and type antibiotics...
Numerous studies suggest overprescribing of antibiotics for respiratory tract indications (RTIs), without really authenticating inappropriate prescription; the strict criteria guideline recommendations were not taken into account as information on specific diagnoses, patient characteristics and disease severity was available. The aim this study is to quantify qualify antibiotic prescribing RTIs. This an observational (antibiotic) management patients with RTIs, using a detailed registration...
Asthma is one of the most common chronic diseases in childhood. According to guidelines, a diagnosis asthma should be confirmed using lung function testing children aged >6 years. Previous studies indicate that probably overdiagnosed. However, extent has not previously been assessed.To assess and characteristics unconfirmed diagnoses who were diagnosed by their GP as having or treated asthma.Retrospective analysis four academic primary healthcare centres Utrecht, Netherlands.Routine care...
<h3>Background</h3> An individualised action plan (AP) is a potentially effective method of helping patients with chronic obstructive pulmonary disease (COPD) to recognise and anticipate early exacerbation symptoms. This multicentre randomised controlled trial evaluates the hypothesis that APs reduce recovery time. <h3>Methods</h3> Two hundred thirty-three COPD (age 65±10 years, forced expiratory volume in 1 s 56±21% predicted) were receive either an AP (n=111) or care as usual (n=122). The...
Outpatients with acute cough who expect, hope for or ask antibiotics may be more unwell, benefit from antibiotic treatment, and satisfied care when they are prescribed antibiotics. Clinicians not accurately identify those patients.To explore whether patient views (expecting, hoping asking antibiotics) associated illness presentation resolution, perceived by clinicians, the association of all these factors prescribing satisfaction care.Prospective observational study 3402 adult patients...
The Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA) demonstrated the efficacy of 13-valent pneumococcal conjugate vaccine (PCV13) preventing vaccine-type community-acquired pneumonia and invasive disease elderly subjects. We examined cost-effectiveness PCV13 vaccination Netherlands. Using a Markov-type model, incremental ratios (ICER) different age- risk-groups for were evaluated using societal perspective. Estimates quality-adjusted life-years (QALYs), costs,...