A5034013469- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Ectopic Pregnancy Diagnosis and Management
- Pediatric Pain Management Techniques
- Reproductive Health and Contraception
- Anesthesia and Pain Management
- Mental Health via Writing
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy-related medical research
- Assisted Reproductive Technology and Twin Pregnancy
- Meta-analysis and systematic reviews
- Grief, Bereavement, and Mental Health
- Global Maternal and Child Health
- Clinical practice guidelines implementation
- Pain Management and Opioid Use
University of Birmingham
2018-2025
University College Birmingham
2025
University of Nairobi
2024
Cancer Research UK Clinical Trials Unit
2019-2020
University of Sheffield
2019
Delays in the detection or treatment of postpartum hemorrhage can result complications death. A blood-collection drape help provide objective, accurate, and early diagnosis hemorrhage, delayed inconsistent use effective interventions may be able to addressed by a bundle.
BackgroundThe anti-progesterone drug mifepristone and the prostaglandin misoprostol can be used to treat missed miscarriage. However, it is unclear whether a combination of more effective than administering alone. We investigated treatment with plus would result in higher rate completion miscarriage compared alone.MethodsMifeMiso was multicentre, double-blind, placebo-controlled, randomised trial 28 UK hospitals. Women were eligible for enrolment if they aged 16 years older, diagnosed by...
Timely detection and treatment of postpartum hemorrhage (PPH) are crucial to prevent complications or death. A calibrated blood-collection drape can help provide objective, accurate early diagnosis PPH, a bundle address delays inconsistencies in the use effective interventions. Here we conducted an economic evaluation alongside E-MOTIVE trial, international, parallel cluster-randomized trial with baseline control phase involving 210,132 women undergoing vaginal delivery across 78...
### What you need to know An early miscarriage is the loss of pregnancy at ≤13 weeks’ gestation.1 It a major life event and can have potentially devastating psychological impact on woman in addition physical effects such as bleeding pain.2 About one four pregnancies, where has missed menstrual period positive test, ends miscarriage.3 Nearly 125 000 miscarriages occur annually UK, accounting for 50 000 hospital admissions.4 Early usually diagnosed by pelvic ultrasound after experienced...
Abstract Objective To check the quality of oxytocin and tranexamic acid—two recommended products for prevention treatment postpartum hemorrhage (PPH)—used in facilities taking part an implementation research project to improve PPH diagnosis management. Methods Between September 2020 August 2021, acid used study Kenya, Nigeria, South Africa, Tanzania were collected transported cold storage analysis. Samples analyzed according International (oxytocin) British Pharmacopeia (tranexamic acid)...
Background Timely detection and treatment of postpartum haemorrhage (PPH) are crucial to prevent complications or death. A calibrated blood-collection drape can help provide objective, accurate, early diagnosis PPH a bundle address delays inconsistencies in the use effective interventions. Methods We conducted an incremental cost-effectiveness analysis alongside E-MOTIVE trial, international, parallel cluster-randomised trial with baseline control phase, designed assess multi-component...
(Abstracted from N Engl J Med 2023;389:11–21) Postpartum hemorrhage (PPH) is a serious complication of childbirth, and delays in diagnosis treatment can cause major complications or fatalities. One method early detection blood-collection drape, possibly conjunction with other tests treatments.
Trial design A randomised, parallel-group, double-blind, placebo-controlled multicentre study with health economic and nested qualitative studies to determine if mifepristone (Mifegyne ® , Exelgyn, Paris, France) plus misoprostol is superior alone for the resolution of missed miscarriage. Methods Women diagnosed miscarriage in first 14 weeks pregnancy were randomly assigned (1 : 1 ratio) receive 200 mg oral or matched placebo, followed by 800 μg 2 days later. web-based randomisation system...
Objectives To explore women’s experiences of remifentanil or pethidine for labour pain and infant feeding behaviours at 6weeks post partum. Design Qualitative postnatal sub-study to the randomised controlled trial intravenous patient analgesia (PCA) versus intramuscular relief in (RESPITE). Semistructured telephone interviews were conducted 6 weeks partum, thematic analysis was undertaken. Setting Women recruited RESPITE from seven UK hospitals. Participants Eighty women consented 49 (30...
To explore differences in obstetric practices and clinical outcomes of postpartum hemorrhage (PPH) Nigerian facilities.A descriptive cross-sectional study public health facilities providing maternal healthcare services Nigeria. Surveys were conducted across 38 purposively sampled (January 2020-March 2021) to collect information on related the management third stage labor, treatment hemorrhage, preceding 12 months.The median number annual births per facility was 2230 (IQR, 1952-3283). The...
Background: Delays in the detection or treatment of postpartum hemorrhage can result complications death. A blood-collection drape help provide objective, accurate, and early diagnosis hemorrhage, delayed inconsistent use effective interventions may be addressed by a bundle. Methods: We conducted an international, cluster-randomized trial to assess multicomponent clinical intervention for vaginal delivery patients. The included calibrated bundle first-response treatments (uterine massage,...
( Lancet . 2018;392:662–672) While pethidine (meperidine) is widely used for pain relief during labor, there are unfavorable side effects, such as nausea/vomiting, maternal sedation, and possible neonatal depression. In addition, more than a third of women receiving ultimately request epidural labor analgesia. Remifentanil potential alternative to relief. Its rapid onset short duration action provide some benefits although its requires administration via intravenous (IV) patient controlled...
( N Engl J Med . 2023;389:11–21) Postpartum hemorrhage (PPH) remains the leading cause of maternal death worldwide despite published recommendations from World Health Organization (WHO) on prevention and treatment. There are challenges in implementing PPH recommendations. Delay detection as well delay treatment 2 reasons rate is high. One reason for due to ongoing use visual estimation blood loss, which often inaccurately underestimates amount lost blood. More aggressive interventions may be...