Chidubem Ogwulu
A5008357548- Reproductive tract infections research
- Adolescent Sexual and Reproductive Health
- Ectopic Pregnancy Diagnosis and Management
- Maternal and Perinatal Health Interventions
- Reproductive Health and Contraception
- Mechanical Circulatory Support Devices
- Syphilis Diagnosis and Treatment
- Sexual function and dysfunction studies
- Cardiac Arrest and Resuscitation
- Global Health Care Issues
- Cardiac Structural Anomalies and Repair
- HIV/AIDS Research and Interventions
- Health Systems, Economic Evaluations, Quality of Life
- Global Maternal and Child Health
- Grief, Bereavement, and Mental Health
- Healthcare Policy and Management
- HIV, Drug Use, Sexual Risk
- Endometriosis Research and Treatment
- Intergenerational Family Dynamics and Caregiving
- Pregnancy and Medication Impact
- Maternal and fetal healthcare
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
University of Birmingham
2015-2025
Miscarriage Association
2019
BackgroundThe anti-progesterone drug mifepristone and the prostaglandin misoprostol can be used to treat missed miscarriage. However, it is unclear whether a combination of more effective than administering alone. We investigated treatment with plus would result in higher rate completion miscarriage compared alone.MethodsMifeMiso was multicentre, double-blind, placebo-controlled, randomised trial 28 UK hospitals. Women were eligible for enrolment if they aged 16 years older, diagnosed by...
Background Progesterone is essential for a healthy pregnancy. Several small trials have suggested that progesterone therapy may rescue pregnancy in women with early bleeding, which symptom strongly associated miscarriage. Objectives (1) To assess the effects of vaginal micronised bleeding first 12 weeks (2) evaluate cost-effectiveness bleeding. Design A multicentre, double-blind, placebo-controlled, randomised trial Setting total 48 hospitals UK. Participants Women aged 16–39 years...
Partner notification (PN) is a process aiming to identify, test and treat the sex partners of people (index patients) with sexually transmitted infections (STIs). Accelerated partner therapy (APT) PN method whereby healthcare professionals assess partners, by telephone consultation, before giving index patient antibiotics STI self-sampling kits deliver their partner(s). The Limiting Undetected Sexually Transmitted RedUce Morbidity programme aims determine effectiveness APT in heterosexual...
To assess the cost-effectiveness of mifepristone and misoprostol (MifeMiso) compared with only for medical management a missed miscarriage.Within-trial economic evaluation model-based analysis to set findings in context wider evidence range comparators. Incremental costs outcomes were calculated using nonparametric bootstrapping reported acceptability curves. Analyses performed from perspective UK's National Health Service (NHS).Twenty-eight UK NHS early pregnancy units.A cohort 711 women...
Trial design A randomised, parallel-group, double-blind, placebo-controlled multicentre study with health economic and nested qualitative studies to determine if mifepristone (Mifegyne ® , Exelgyn, Paris, France) plus misoprostol is superior alone for the resolution of missed miscarriage. Methods Women diagnosed miscarriage in first 14 weeks pregnancy were randomly assigned (1 : 1 ratio) receive 200 mg oral or matched placebo, followed by 800 μg 2 days later. web-based randomisation system...
Background Sexually transmitted infections disproportionately affect young people and men who have sex with men. Chlamydia is Britain’s most common sexually infection. Partner notification a key intervention to reduce transmission of human immunodeficiency virus but hard implement. Accelerated partner therapy promising new approach. Objectives determine the effectiveness, costs acceptability accelerated for chlamydia in heterosexual model cost effectiveness impact on develop interventions...
ABSTRACT Objective To investigate the cost-effectiveness of accelerated partner therapy (APT) compared with standard contact tracing for people sexually transmitted chlamydia infection in United Kingdom Design Economic evaluation using a model consisting two components: population-based transmission component, to estimate impact APT on prevalence, and an economic healthcare costs health outcomes. Setting Participants Hypothetical heterosexual population 50,000 men women aged 16-34 years....
( N Engl J Med . 2019;380(19):1815–1824) This study aimed to determine whether the controversial use of progesterone therapy in women with early bleeding pregnancy could result a higher incidence live births than placebo. It was multicenter, randomized, double-blind, placebo-controlled trial evaluate progesterone, as compared placebo, vaginal pregnancy. Women received suppositories or from presentation 16 weeks if helps improve outcomes for
<h3>Background</h3> Accelerated partner therapy (APT) is a notification (PN) method whereby healthcare professionals assess sex partners by telephone, then send or give the index patient antibiotics and self-sampling kits for their partner(s). We determined effect of APT on proportions of: patients who test positive chlamydia at 12–24 weeks (primary outcome) treated (key secondary outcome). <h3>Methods</h3> did cross-over cluster-randomised controlled trial comparing APT, as an additional PN...
ABSTRACT Background Eliciting health-state utility values (HSUVs) for some diseases is complicated by the mix of associated temporary (THSs) and chronic health states (CHSs). This study uses one such disease, chlamydia infection, to explore challenges. The objectives were to: Define a set descriptions related Derive HSUVs these (both chronic). Methods elicited seven (five THSs two CHSs) depicting symptoms chlamydia, developed using evidence from literature clinical experts. chained time...
ABSTRACT Objectives Men who have sex with men (MSM) are disproportionately affected by sexually transmitted infections (STIs). Partner notification (PN) to identify, test and treat partners of MSM bacterial STIs is challenging because often report larger numbers a higher proportion one-off may be difficult engage. However, contribute onward transmission. Economic research on PN has typically focused heterosexual people evidence effectiveness in scant. We conducted systematic review economic...
<h3>Background</h3> Accelerated partner therapy (APT) is a notification (PN) method whereby healthcare professionals assess sex partners by telephone, then send or give the index patient antibiotics and self-sampling kits for their partner(s). APT was implemented within cluster cross-over randomised control trial in 17 sexual health clinics Britain (2018–2019, ISRCTN Reference 15996256). We conducted an integral process evaluation to help explain experiences of using APT. <h3>Methods</h3>...