A5102728269- Ectopic Pregnancy Diagnosis and Management
- Gynecological conditions and treatments
- Uterine Myomas and Treatments
- Hormonal Regulation and Hypertension
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Reproductive Health and Contraception
- Assisted Reproductive Technology and Twin Pregnancy
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Pregnancy-related medical research
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Female Genital Mutilation/Cutting Issues
- Ovarian function and disorders
- Gestational Trophoblastic Disease Studies
- Medical Education and Admissions
- Cardiac Imaging and Diagnostics
- Adrenal Hormones and Disorders
- Ovarian cancer diagnosis and treatment
- Fetal and Pediatric Neurological Disorders
- Pregnancy and preeclampsia studies
- Delphi Technique in Research
- Cancer Risks and Factors
- Cystic Fibrosis Research Advances
St Thomas' Hospital
2009-2024
Guy's and St Thomas' NHS Foundation Trust
2009-2024
The National Autistic Society
2024
St Bartholomew's Hospital
1998-2003
Guy's Hospital
2003
University of Toronto
1979
Royal Edinburgh Hospital
1971
Yeshiva University
1963-1965
Albert Einstein College of Medicine
1963-1965
BackgroundThe anti-progesterone drug mifepristone and the prostaglandin misoprostol can be used to treat missed miscarriage. However, it is unclear whether a combination of more effective than administering alone. We investigated treatment with plus would result in higher rate completion miscarriage compared alone.MethodsMifeMiso was multicentre, double-blind, placebo-controlled, randomised trial 28 UK hospitals. Women were eligible for enrolment if they aged 16 years older, diagnosed by...
Objectives To validate recent guidance changes by establishing the performance of cut-off values for embryo crown-rump length and mean gestational sac diameter to diagnose miscarriage with high levels certainty. Secondary aims were examine influence age on interpretation values, determine optimal intervals between scans findings repeat that definitively pregnancy failure. ) Design Prospective multicentre observational trial. Setting Seven hospital based early assessment units in United...
Quantitative biochemical assays and histochemical studies of Δ5-3β- hydroxysteroid dehydrogenase activity in adrenals ovaries from animals various mammalian orders lend support to the thesis a pathway steroid biosynthesis that is common both organs all species, is, via oxidation Δ5-3β-hydroxysteroids Δ4-3-ketosteroids. However, differences exist among species levels enzymic activity. There are also several interesting locations this
Saline hysterosonography was attempted as a routine, first-line screening test of uterine structure in 500 consecutive, unselected, infertile women. The procedure completed 96.8% (484/500) women and the observations were interpretable 483 these Intrauterine pathology suspected 67/499 (13.4%) on plain ultrasound scan 58/484 (12%) with saline hysterosonography. Ultrasound alone had superior specificity (96.3%) to sensitivity (81.8%) better negative (97.6%) than positive (73.8%) predictive...
Δ5-3β-Hydroxysteroid dehydrogenase activity has been determined both biochemically and histochemically in the ovaries of rats between 22 98 days age. By criteria, was low at time initial ovulation (5 weeks). It subsequently increased reached a peak about 9–10 weeks. This significantly above normal adult level.
To assess the cost-effectiveness of mifepristone and misoprostol (MifeMiso) compared with only for medical management a missed miscarriage.Within-trial economic evaluation model-based analysis to set findings in context wider evidence range comparators. Incremental costs outcomes were calculated using nonparametric bootstrapping reported acceptability curves. Analyses performed from perspective UK's National Health Service (NHS).Twenty-eight UK NHS early pregnancy units.A cohort 711 women...
Trial design A randomised, parallel-group, double-blind, placebo-controlled multicentre study with health economic and nested qualitative studies to determine if mifepristone (Mifegyne ® , Exelgyn, Paris, France) plus misoprostol is superior alone for the resolution of missed miscarriage. Methods Women diagnosed miscarriage in first 14 weeks pregnancy were randomly assigned (1 : 1 ratio) receive 200 mg oral or matched placebo, followed by 800 μg 2 days later. web-based randomisation system...
Changes in ovarian weight and Δ6-3β-hydroxysteroid dehydrogenase activity were measured at intervals of 1, 2 4 weeks after hemicastration rats different ages. The changes the indices often not parallel. extent response obtained or enzymic any above was dependent on age rat when performed. significance these findings is discussed with regard to mechanisms responsible for compensatory changes. It also observed that removal one ovary from prepuberal caused a delay onset puberty. would appear...
National guidelines have for many years stated that a fetus with CRL greater than or equal to 6 mm no visible fetal heart beat (FH) can be diagnosed as miscarriage. With high resolution ultrasound machines some would argue this cut off could lowered, while others advise caution. The current literature does not give definitive answer. Retrospective analysis of database 21,133 early pregnancy scans performed at tertiary referral unit between 2003 and 2011. A only 1.0–1.9 allowed an 88.8%...
<h3>Background:</h3> Axial spondyloarthritis (axSpA) affects women of childbearing age and is associated with an increased prevalence pregnancy complications. There are limited UK data available on axSpA during pregnancy. Retrospective disease activity in suggests that approximately one-third patients remain remission, show improvement, experience a flare. The most common risk factor for flare was active at conception. A systematic meta-analysis analysing peri-pregnancy scores reported rates...
This case report describes the rare finding of a granulosa cell tumour in third trimester pregnancy. The presentation, investigation, management, histopathological findings and subsequent follow up are detailed. difficulties associated with such diagnoses pregnancy explored.
The World Health Organization characterizes obesity as a pandemic global health issue. Obesity poses challenges in the management of ectopic pregnancy, through difficulties ultrasonography and increased surgical risks. We investigated whether being overweight was barrier to diagnosis or successful medical pregnancy. A retrospective study performed on 114 consecutive patients who underwent pregnancy unknown location (PUL) between 1st Jan 2009 31st Dec 2011. were divided into two groups based...
To establish if there is a difference between left and right sided ectopic pregnancy rates anatomical position has any relationship to clinical presentation. Previous studies have concluded with either support for Berlind's theory of ovum transmigration or no proven ovulation the risk (1, 2). Analysis computerised databases in tertiary referral centre, from 2002–2013 retrospectively compared site corpus luteum on transvaginal scanning as well associated symptoms. We found right-sided tubal...
RésuméDans cet article, on décrit l'expérience vécue par sept femmes, professionnelles du domaine de la santé mentale, qui formaient un groupe libre, c'est-à-dire sans leader, cela sur une période d'un an et demi.On discute d'abord des conflits pertinents aux femmes dans quatre domaines importants: compétition, les besoins dépendance, le succès point vue économique recherche modèles rôles. On suggère ensuite solutions éventuellement efficaces pour ces conflictuels. Les sont résultat...
We describe the acute deterioration of a 29-year-old undergoing in vitro fertilisation. Late-onset critical ovarian hyperstimulation syndrome triggered massive pulmonary embolism and subsequent cardiac arrest. While prognosis was deemed to be poor, patient made full recovery. The potential reasons for this are explored.
The United Nations has called for an end to ritual female genital mutilation, a practice which estimated 130 million girls and women worldwide have been subjected. The heads of the WHO, Unicef, Population Fund published statement last week calling international effort bring about “major decline” within 10 years in what they …
In March 2020, due to the COVID-19 pandemic, a tertiary referral gynecology department suspended all elective surgery and benign outpatient clinics. 2019 there were 32,000 visits 2,400 operations performed for disease. We examined impact that this decision had on timing route by which women accessed care outcome. A prospective registry was established. Any woman reviewed emergency team who stated they delayed their presentation concerns about COVID-19, presented an inability access...