A5009892854- Atrial Fibrillation Management and Outcomes
- Dementia and Cognitive Impairment Research
- Cardiac pacing and defibrillation studies
- Obesity, Physical Activity, Diet
- Venous Thromboembolism Diagnosis and Management
- Vestibular and auditory disorders
- Geriatric Care and Nursing Homes
- Obesity and Health Practices
- Schizophrenia research and treatment
- Reproductive Health and Contraception
- Ectopic Pregnancy Diagnosis and Management
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Maternal and Perinatal Health Interventions
- Health Policy Implementation Science
- Physical Activity and Health
- Breastfeeding Practices and Influences
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Central Venous Catheters and Hemodialysis
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- graph theory and CDMA systems
- Finite Group Theory Research
- Meta-analysis and systematic reviews
- Mental Health Treatment and Access
University of Birmingham
2004-2024
Cancer Research UK Clinical Trials Unit
2019-2024
NIHR Birmingham Biomedical Research Centre
2020
Bangor University
2013-2020
University of Hull
2015
Oxford Health NHS Foundation Trust
2015
Alzheimer's Society
2015
University College London
2015
We compared mindfulness-based cognitive therapy (MBCT) with both psychological education (CPE) and treatment as usual (TAU) in preventing relapse to major depressive disorder (MDD) people currently remission following at least 3 previous episodes.A randomized controlled trial which 274 participants were allocated the ratio 2:2:1 MBCT plus TAU, CPE TAU alone, data analyzed for 255 (93%; = 99, 103, 53) retained follow-up. was delivered accordance its published manual, modified address suicidal...
Objective: This study evaluated the impact of antipsychotic review, social interaction, and exercise, in conjunction with person-centered care, on use, agitation, depression people dementia living nursing homes. Method: A cluster-randomized factorial controlled trial two replications was conducted 16 U.K. All homes received training care. Eight were randomly assigned to a interaction intervention, an exercise intervention for 9 months, most more than one intervention. The primary outcome...
BackgroundThe anti-progesterone drug mifepristone and the prostaglandin misoprostol can be used to treat missed miscarriage. However, it is unclear whether a combination of more effective than administering alone. We investigated treatment with plus would result in higher rate completion miscarriage compared alone.MethodsMifeMiso was multicentre, double-blind, placebo-controlled, randomised trial 28 UK hospitals. Women were eligible for enrolment if they aged 16 years older, diagnosed by...
Background Very few interventional studies have directly examined the impact of treatment approaches on health-related quality life (HRQL) in people with dementia. This is particular importance therapies to address behavioural symptoms, where HRQL often severely affected. Methods Analysis within WHELD cluster randomised factorial study 16 UK care homes examining person-centred combination antipsychotic review, social interaction and exercise interventions. analysed through DEMQOL-Proxy....
Summary Venous thromboembolism (VTE) is prevalent and impactful, with a risk of death, morbidity recurrence. Post‐thrombotic syndrome (PTS) common consequence associated impaired quality life (QoL). The ExACT study was non‐blinded, prospective, multicentred randomised controlled trial comparing extended versus limited duration anticoagulation following first unprovoked VTE (proximal deep vein thrombosis or pulmonary embolism). Adults were eligible if they had completed ≥3 months (remaining...
Background Patients with permanent atrial fibrillation have poor outcomes, exercise capacity, and quality of life even on optimal anticoagulation. Based mechanistic observational data, we tested whether the mineralocorticoid receptor antagonist spironolactone can improve E/e' ratio, in patients preserved ejection fraction. Methods Results The double‐masked, placebo‐controlled IMPRESS‐AF (Improved Exercise Tolerance Heart Failure With Preserved Ejection Fraction by Spironolactone Myocardial...
Idiopathic sudden sensorineural hearing loss (ISSNHL) is the rapid onset of reduced due to function inner ear or nerve unknown aetiology. Evidence supports improved recovery with early steroid treatment, via oral, intravenous, intratympanic a combination routes. The STARFISH trial aims identify most clinically and cost-effective route administration steroids as first-line treatment for ISSNHL. pragmatic, multicentre, assessor-blinded, three-arm intervention, superiority randomised controlled...
Abstract Aims The aim is to describe the rationale, design, delivery, and baseline characteristics of Stroke prevention rhythm control Treatment: Evaluation an Educational programme European society cardiology in a cluster-Randomized trial patients with Atrial Fibrillation (STEEER-AF) trial. Methods results STEEER-AF pragmatic designed objectively robustly determine whether guidelines are adhered routine practice evaluate targeted educational for healthcare professionals. Seventy centres...
Background The effective management of agitation and other neuropsychiatric behavioural symptoms in people with dementia is a major challenge, particularly care home settings, where severity higher there limited training support for staff. There evidence the value staff use psychosocial approaches; however, no intervention currently exists that combines these elements into an fit purpose settings based on from randomised controlled trial. Objective objective was to develop evaluate complex...
To assess (1) the feasibility of delivering a culturally adapted weight management programme, Healthy Dads, Kids United Kingdom (HDHK-UK), for fathers with overweight or obesity and their primary school-aged children, (2) conducting definitive randomised controlled trial (RCT).A two-arm, mixed-methods process evaluation.Socioeconomically disadvantaged, ethnically diverse localities in West Midlands, UK.Fathers children aged 4-11 years.Participants were 1:2 ratio to control (family voucher...
Trial design A randomised, parallel-group, double-blind, placebo-controlled multicentre study with health economic and nested qualitative studies to determine if mifepristone (Mifegyne ® , Exelgyn, Paris, France) plus misoprostol is superior alone for the resolution of missed miscarriage. Methods Women diagnosed miscarriage in first 14 weeks pregnancy were randomly assigned (1 : 1 ratio) receive 200 mg oral or matched placebo, followed by 800 μg 2 days later. web-based randomisation system...
Background More men than women in the UK are living with overweight or obesity, but less likely to engage weight loss programmes. Healthy Dads, Kids is an effective Australian management programme that targets fathers, who participate their primary school-aged children. Behavioural interventions do not always transfer between contexts, so adaptation of ethnically diverse setting was trialled. Objectives To adapt and test for delivery diverse, socioeconomically disadvantaged setting. Design...
ABSTRACT In Lucchini et al. (2000 , A. Tamburini M. C. Wilson J. S. ( 2000 ). Hurwitz groups of large rank . London Math. Soc. 61 2 ): 81 – 92 [CSA] [CROSSREF] [Crossref] [Google Scholar]), proved, in particular, that the SL n (q) and (Z) are (2, 3, 7)-generated for each prime power q integer ≥ 287, where Z is ring integers. Moreover, method used their article also applies 93 smaller ranks less than our interest here finding other small which 7)-generation can be established. this article,...
Introduction Aortic stenosis (AS) is common affecting >13% of adults over the age 75 years. In people who develop symptoms, without valve replacement, prognosis dismal with mortality as high 50% at 1 year. asymptomatic patients, timing intervention less well defined and a strategy watchful waiting recommended. Many, however, may symptoms attribute this to related decline, rather than worsening AS. Timely in severe AS critical, since delayed often results poor outcomes. Proactive...
Abstract Idiopathic sudden sensorineural hearing loss (ISSNHL) is the rapid onset of reduced due to function inner ear or nerve unknown aetiology. Evidence supports improved recovery with early steroid treatment, via oral, intravenous, intratympanic a combination routes. The STARFISH trial aims identify most clinically and cost-effective route administration steroids as first-line treatment for ISSNHL. pragmatic, multicentre, assessor-blinded, three-arm intervention, superiority randomised...
Introduction Patients with atrial fibrillation frequently suffer from heart failure despite having a normal ejection fraction. There is no proven therapy to improve physical capacity and quality of life in patients permanent preserved cardiac contractility. Objective The IMproved exercise tolerance PReserved Ejection fraction by Spironolactone on myocardial fibrosiS Atrial Fibrillation (IMPRESS-AF) trial addressed whether or not 2 years treatment spironolactone, as compared placebo, improves...
Background Deep-vein thrombosis and pulmonary embolism, collectively known as venous thromboembolism when clots are formed in the circulation, common disorders that often unprovoked (i.e. there is no obvious reason for clot occurring). Some people, after having an clot, at a high risk of developing another, or secondary most importantly lungs. Furthermore, long term, some patients will develop circulation problems post-thrombotic syndrome. The aim this programme was to improve understanding...
Abstract In Everitt [Everitt, B. J. (2000). Alternating quotients of Fuchsian groups. Algebra 223: 457–476], it was shown, in particular, that each triangle group Δ(p, q, r) has among its homomorphic images all but finitely many the alternating Treating p, q as fixed, methods (2000) give a quadratic function N(r) r such A n is an image for every integer ≥ N(r). We conjecture there linear with this property. paper, we will show holds groups Δ(3, r).