Eduard Guasch
A5021523651- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
- Photochromic and Fluorescence Chemistry
- Neurological disorders and treatments
- Photoreceptor and optogenetics research
- Sports injuries and prevention
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- ECG Monitoring and Analysis
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Cardiac Fibrosis and Remodeling
- Cardiovascular Health and Disease Prevention
- Advanced X-ray Imaging Techniques
- Receptor Mechanisms and Signaling
Universitat de Barcelona
2016-2025
Centro de Investigación Biomédica en Red
2017-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Hospital Clínic de Barcelona
2016-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2025
Institut d'Investigacions Biomèdiques de Barcelona
2025
Instituto de Salud Carlos III
2018-2022
Hudson Institute
2020
Northwestern University
2020
Hospital Universitari i Politècnic La Fe
2020
Background— Recent clinical studies suggest that endurance sports may promote cardiac arrhythmias. The aim of this study was to use an animal model evaluate whether sustained intensive exercise training induces potentially adverse myocardial remodeling and thus creates a potential substrate for Methods Results— Male Wistar rats were conditioned run vigorously 4, 8, 16 weeks; time-matched sedentary served as controls. Serial echocardiograms in vivo electrophysiological at weeks obtained both...
AMI : acute myocardial infarction ARVC : arrhythmogenic right ventricular cardiomyopathy BrS : Brugada syndrome CACS : coronary artery calcium score CAD : disease ChD : Chagas heart disease CMR : cardiac magnetic resonance CPVT : catecholaminergic polymorphic tachycardia CTCA : computed tomography angiography CV : cardiovascular DCM : dilated cardiomyopathy EAPCR : European Association for Cardiovascular Prevention and Rehabilitation HCM : hypertrophic cardiomyopathy LGE : late gadolinium...
Abstract Background Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether combination high-flow nasal oxygen therapy (HFNO) with awake-PP prevents need for intubation when compared HFNO alone. Methods Prospective, multicenter, adjusted observational cohort study consecutive COVID-19 acute respiratory failure (ARF)...
Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity mortality even on optimal current therapy. This document summarizes key outcomes 8th AFNET/EHRA Consensus Conference Atrial Fibrillation NETwork (AFNET) European Heart Rhythm Association (EHRA). Eighty-three international experts met Hamburg for 2 days October 2021. Results interdisciplinary, hybrid discussions breakout groups plenary...
Conduction system pacing (CSP) has emerged as an alternative to biventricular (BiVP). Randomized studies comparing both therapies are scarce and do not include left bundle branch pacing. This study aims compare ventricular resynchronization achieved by CSP vs BiVP in patients with cardiac therapy indication. LEVEL-AT (Left Ventricular Activation Time Shortening System Pacing Biventricular Resynchronization Therapy) was a randomized, parallel, controlled, noninferiority trial. Seventy...
Abstract Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated risk AF-related complications. The aim this document to summarize key outcomes 9th AFNET/EHRA Consensus Conference Atrial Fibrillation NETwork (AFNET) European Heart Rhythm Association (EHRA). Methods results Eighty-three international experts met Münster for 2 days September 2023. Key findings...
Background— Atrial tissue fibrosis is often an important component of the atrial fibrillation (AF) substrate. Small noncoding microRNAs are mediators in many cardiac remodeling paradigms. MicroRNA-21 (miR-21) has been suggested to be ventricular fibrotic by downregulating Sprouty-1, a protein that suppresses fibroblast proliferation. The present study examined potential role miR-21 AF substrate resulting from experimental heart failure after myocardial infarction (MI). Methods and Results—...
Late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) provides tissue characterization of ventricular myocardium and scar that can be depicted as pixel signal intensity (PSI) maps.To assess the possible benefit guiding tachycardia (VT) substrate mapping by integrating these PSI maps into navigation system.In total, 159 consecutive patients (66 ± 11 years old, 151 men [95%]) with scar-related left (LV) VT were included. ablation used dechanneling technique. A CMR-aided using was...
The role of high-intensity exercise and other emerging risk factors in lone atrial fibrillation (Ln-AF) epidemiology is still under debate. aim this study was to analyse the contribution each impact physical activity dose patients with Ln-AF.Patients Ln-AF age- sex-matched healthy controls were included a 2:1 prospective case-control study. We obtained clinical anthropometric data transthoracic echocardiography, lifetime questionnaire, 24-h ambulatory blood pressure monitoring, Berlin...
Identification of left atrial (LA) fibrosis through late gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) remains controversial due to the heterogeneity and lack reproducibility proposed methods. Our aim is describe a normalized, reproducible, standardized method evaluate LA LGE-CMR.Electrocardiogram- respiratory-gated 3-Tesla LGE-CMR was performed in 10 healthy young volunteers 30 patients with fibrillation (AF): paroxysmal AF, persistent previous AF ablation procedure. Local image...
There are major challenges ahead for clinicians treating patients with atrial fibrillation (AF). The population AF is expected to expand considerably and yet, apart from anticoagulation, therapies used in have not been shown consistently impact on mortality or reduce adverse cardiovascular events. New approaches management, including the use of novel technologies structured, integrated care, potential enhance clinical phenotyping result better treatment selection stratified therapy. Here, we...
Abstract Background Critically ill patients with coronavirus disease 19 (COVID-19) have a high fatality rate likely due to dysregulated immune response. Corticosteroids could attenuate this inappropriate response, although there are still some concerns regarding its use, timing, and dose. Methods This is nationwide, prospective, multicenter, observational, cohort study in critically adult COVID-19 admitted into Intensive Care Units (ICU) Spain from 12th March 29th June 2020. Using...
Abstract Aims Myocardial fibrosis is a hallmark of atrial fibrillation (AF) and its characterization could be used to guide ablation procedures. Late gadolinium enhanced-magnetic resonance imaging (LGE-MRI) detects areas fibrosis. However, accuracy remains controversial. We aimed analyse the LGE-MRI identify left (LA) arrhythmogenic substrate by analysing voltage conduction velocity at LGE. Methods results was performed before in 16 patients. Atrial wall intensity normalized blood pool...
Abstract Background and Aims In patients with atrial fibrillation (AF), recurrent AF sinus rhythm during follow-up are determined by interactions between cardiovascular disease processes control therapy. Predictors of attaining at not well known. Methods To quantify the interaction outcomes, 14 biomarkers reflecting AF-related in 1586 EAST-AFNET 4 biomolecule study (71 years old, 45% women) were quantified baseline. Mixed logistic regression models including clinical features constructed for...
Long-term endurance sport practice has been increasingly recognized as a risk factor for lone atrial fibrillation (AF). However, data on the outcome of circumferential pulmonary vein ablation (CPVA) in athletes are scarce. The aim study was to evaluate efficacy CPVA AF secondary practice. Patients submitted answered questionnaire about lifetime history Endurance were defined those who engaged >3 h per week high-intensity exercise at least 10 years immediately preceding their diagnosis. A...
Light-triggered reversible modulation of physiological functions offers the promise enabling on-demand spatiotemporally controlled therapeutic interventions. Optogenetics has been successfully implemented in heart, but significant barriers to its use clinic remain, such as need for genetic transfection. Herein, we present a method modulate cardiac function with light through photoswitchable compound and without manipulation. The molecule, named PAI, was designed by introduction photoswitch...