A5062434872- Statistical Methods in Clinical Trials
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Meta-analysis and systematic reviews
- Statistical Methods and Bayesian Inference
- Cardiac, Anesthesia and Surgical Outcomes
- Statistical Methods and Inference
- SARS-CoV-2 and COVID-19 Research
- Mental Health Treatment and Access
- Health Systems, Economic Evaluations, Quality of Life
- Orthodontics and Dentofacial Orthopedics
- Hemodynamic Monitoring and Therapy
- Acute Ischemic Stroke Management
- Dental Radiography and Imaging
- Cardiovascular Function and Risk Factors
- Advanced Causal Inference Techniques
- Stroke Rehabilitation and Recovery
- Digital Mental Health Interventions
- Endodontics and Root Canal Treatments
- Health and Medical Studies
- COVID-19 epidemiological studies
- Amyotrophic Lateral Sclerosis Research
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
University Medical Center Hamburg-Eppendorf
2018-2025
Universität Hamburg
2018-2025
Harvard University Press
2025
Zimmer Biomet (Germany)
2009-2024
German Centre for Cardiovascular Research
2022-2024
Atrial Fibrillation NETwork
2024
University Cancer Center Hamburg
2024
Gunadarma University
2024
Hong Kong Polytechnic University
2024
Jianghan University
2024
Reliability of measurements is a prerequisite medical research. For nominal data, Fleiss' kappa (in the following labelled as K) and Krippendorff's alpha provide highest flexibility available reliability measures with respect to number raters categories. Our aim was investigate which confidence intervals best statistical properties for assessment inter-rater in different situations.We performed large simulation study precision estimates K determine empirical coverage probability...
Device-detected atrial high-rate episodes (AHREs) are arrhythmias detected by implanted cardiac devices. AHREs resemble fibrillation but rare and brief. Whether the occurrence of in patients without (as documented on a conventional electrocardiogram [ECG]) justifies initiation anticoagulants is not known. Download PDF Research Summary. We conducted an event-driven, double-blind, double-dummy, randomized trial involving 65 years age or older who had lasting for at least 6 minutes one...
BACKGROUND: Device-detected atrial fibrillation (also known as subclinical or high-rate episodes) is a common finding in patients with an implanted cardiac rhythm device and associated increased risk of ischemic stroke. Whether oral anticoagulation effective safe this patient population unclear. METHODS: We performed systematic review MEDLINE Embase for randomized trials comparing antiplatelet no antithrombotic therapy adults device-detected recorded by pacemaker, implantable cardioverter...
The randomized EAST-AFNET4 (Early Treatment of Atrial Fibrillation for Stroke Prevention Trial-Atrial Network) demonstrated that early rhythm control (ERC) reduces adverse cardiovascular outcomes in patients with recently diagnosed atrial fibrillation and stroke risk factors. effectiveness safety ERC multiple comorbidities is not known.
Abstract Aims A strategy of systematic, early rhythm control (ERC) improves cardiovascular outcomes in patients with atrial fibrillation (AF). It is not known how this outcome-reducing effect mediated. Methods and results Using the Early treatment Atrial Fibrillation for Stroke prevention Trial (EAST—AFNET 4) data set, potential mediators ERC were identified total study population at 12-month follow up further interrogated by use a four-way decomposition an exponential model predicting...
Autologous chondrocyte (CC) transplantation has the disadvantages of requiring two surgical interventions and in vitro expansion cells, implying risk cellular dedifferentiation. Our clinical aim is to develop a one-step procedure for autologous CC transplantation, i.e. harvesting, isolation reimplantation performed one single procedure. Platelet-rich plasma (PRP) source growth factors reported have mitogenic effects. The objective this study was test influence PRP as an scaffold on freshly...
Rödig T, Vogel S, Zapf A, Hülsmann M. Efficacy of different irrigants in the removal calcium hydroxide from root canals. International Endodontic Journal . 43 , 519–527, 2010. Abstract Aim To compare efficacy solutions (1% sodium hypochlorite, 10% citric acid and 20% EDTA) Methodology One hundred single‐rooted maxillary incisors were prepared to size 50 split longitudinally. Two standardized grooves cut into apical coronal part canal dentine filled with hydroxide. The reassembled teeth...
The value of the signs and symptoms pregnancy diagnostic test as predictors was estimated for 1,592 women seen in general practice. presence a sign or symptom alone is poor pointer to diagnosis pregnancy. combination pairs features improves value, best being breast combined with either on vaginal examination palpable fundus, both giving predictive values 0·89. alone, however, had 0·91, 1·00 indicating 100 per cent reliability.
ABSTRACT Objectives: Transient elastography (TE) using the FibroScan has gained popularity recently for noninvasive diagnosis of hepatic fibrosis. Data on its use in children younger than 6 years are still scarce, and influence technical aspects such as probe choice site measurement results is not clear. Our study aims to clarify some issues concerning deliver normal values reference. Methods: TE was performed 527 (229 girls, ages 0.1–17.8 [median 6.0] years, including 400 healthy controls)....
Intrahospital time delays significantly affect the neurological outcome of stroke patients with large-vessel occlusion. This study was conducted to determine whether a one-stop management can reduce intrahospital times acute occlusion.In this observational study, we report first 30 consecutive imaged and treated in same room. As part our protocol, transported National Institutes Health Stroke Scale score ≥10 directly angio suite, bypassing multidetector computed tomography (CT)....
Weight loss is a frequent feature in the motor neuron disease Amyotrophic lateral sclerosis (ALS). In this study we investigated possible causes of weight ALS, its impact on mood/quality life (QOL) and benefit high calorie nutritional/other dietary supplements percutaneous endoscopic gastrostomy (PEG). 121 ALS patients were interviewed answered standardized questionnaires (Beck depression inventory - II, SF36 Health Survey questionnaire, revised functional rating scale). Two years after...
Introduction Persistent somatic symptoms (PSS) are highly prevalent in all areas of medicine; they disabling for patients and costly society. The subjective symptom burden often correlates poorly with the underlying disease severity, patients’ needs effective treatment far from being met. Initial evidence indicates that, addition to disease-specific pathophysiological processes, psychological factors such as expectations, somatosensory amplification prior illness experiences contribute...
Abstract Background and Aims Patients with long atrial high-rate episodes (AHREs) ≥24 h stroke risk factors are often treated anticoagulation for prevention. Anticoagulation has never been compared no in these patients. Methods This secondary pre-specified analysis of the Non-vitamin K antagonist Oral anticoagulants patients Atrial High-rate (NOAH-AFNET 6) trial examined interactions between AHRE duration at baseline edoxaban placebo factors. The primary efficacy outcome was a composite...
Image analysis assistance with artificial intelligence (AI) has become one of the great promises over recent years in pathology, many scientific studies being published each year. Nonetheless, and perhaps surprisingly, only few image AI systems are already routine clinical use. A major reason for this is missing validation robustness systems: beyond a narrow context, large variability digital images due to differences preanalytical laboratory procedures, staining scanners can be challenging...
Short and rare episodes of atrial fibrillation (AF) are commonly detected using implanted devices (device-detected AF) in patients with prior stroke or transient ischemic attack (TIA). The effectiveness safety oral anticoagulation TIA device-detected AF but no ECG-documented is unclear.
Abstract Background and Aims In patients with atrial fibrillation (AF), recurrent AF sinus rhythm during follow-up are determined by interactions between cardiovascular disease processes control therapy. Predictors of attaining at not well known. Methods To quantify the interaction outcomes, 14 biomarkers reflecting AF-related in 1586 EAST-AFNET 4 biomolecule study (71 years old, 45% women) were quantified baseline. Mixed logistic regression models including clinical features constructed for...
Abstract Aims Clinical concerns exist about the potential proarrhythmic effects of sodium channel blockers (SCBs) flecainide and propafenone in patients with cardiovascular disease. Sodium were used to deliver early rhythm control (ERC) therapy EAST-AFNET 4. Methods results We analysed primary safety outcome (death, stroke, or serious adverse events related therapy) efficacy (cardiovascular death, hospitalization for worsening heart failure (HF) acute coronary syndrome) during SCB intake ERC...
The prognosis for patients with oral squamous cell carcinoma remains poor despite advances in multimodal treatment concepts. Early diagnosis and is the key to improved patient survival. A device (VELscope) that uses autofluorescence technology, allowing direct fluorescence visualization of cavity, might be a useful tool cancer detection or as an adjunct standard clinical examination. total 289 premalignant lesions were randomly divided into two groups examination precancerous lesions. In...
The forces delivered by aligners during torquing have still not been investigated. purpose of this study was to measure the an upper central incisor with three different materials same thickness, and describe biomechanical principles aligners. Five identical appliances were manufactured from each materials, all a thickness 1.0 mm (Ideal Clear®, Erkodur®, Biolon®). An incisor, as part measuring device, torqued in defined steps vestibular palatal directions respective appliance place. For...
Due to lack of any curative therapy for ALS, symptomatic treatment and maintenance quality life (QoL) is very important. We aimed characterize the affected domains QoL in ALS patients identify factors which are associated with reduced increased depression.159 answered standardized questionnaires (Beck Depression Inventory-II, SF-36 Health Survey questionnaire, revised functional rating scale). Multiple regression analysis was used correlations between clinical features depression/QoL scores....