Mirko De Melis

ORCID: 0000-0002-9223-4183
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About
Contact & Profiles
Research Areas
  • Atrial Fibrillation Management and Outcomes
  • Cardiac Arrhythmias and Treatments
  • Non-Invasive Vital Sign Monitoring
  • Cardiac electrophysiology and arrhythmias
  • Heart Rate Variability and Autonomic Control
  • Cardiac pacing and defibrillation studies
  • Cardiovascular Health and Disease Prevention
  • ECG Monitoring and Analysis
  • Cardiovascular Syncope and Autonomic Disorders
  • Optical Imaging and Spectroscopy Techniques
  • Hemodynamic Monitoring and Therapy
  • Blood Pressure and Hypertension Studies
  • Cardiac Imaging and Diagnostics
  • Cardiac, Anesthesia and Surgical Outcomes
  • Health Systems, Economic Evaluations, Quality of Life
  • Healthcare Technology and Patient Monitoring
  • Advanced Fiber Optic Sensors
  • Cardiovascular Function and Risk Factors
  • Advanced Fiber Laser Technologies
  • Phonocardiography and Auscultation Techniques
  • EEG and Brain-Computer Interfaces
  • Cardiovascular and exercise physiology
  • GDF15 and Related Biomarkers
  • Vitamin K Research Studies
  • Spaceflight effects on biology

Medtronic (Netherlands)
2016-2025

Medtronic (United States)
2021

Maastricht University
2021

Bakken Museum
2013-2020

Medtronic (Ireland)
2020

University of Louisville
2019

Columbia University
2013

Valley Health System
2013

Ghent University
2008

Ghent University Hospital
2008

The aim of this study was to assess the association between maximum daily atrial fibrillation (AF) burden and risk ischaemic stroke. Cardiac implanted electronic devices (CIEDs) enhance detection AF, providing a comprehensive measure AF burden. A pooled analysis individual patient data from five prospective studies performed. Patients without permanent previously with CIEDs, were included if they had at least 3 months follow-up. total 10 016 patients (median age 70 years) met these criteria....

10.1093/eurheartj/eht491 article EN cc-by-nc European Heart Journal 2013-12-11

Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity mortality even on optimal current therapy. This document summarizes key outcomes 8th AFNET/EHRA Consensus Conference Atrial Fibrillation NETwork (AFNET) European Heart Rhythm Association (EHRA). Eighty-three international experts met Hamburg for 2 days October 2021. Results interdisciplinary, hybrid discussions breakout groups plenary...

10.1093/europace/euac062 article EN cc-by-nc EP Europace 2022-04-15

Abstract Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated risk AF-related complications. The aim this document to summarize key outcomes 9th AFNET/EHRA Consensus Conference Atrial Fibrillation NETwork (AFNET) European Heart Rhythm Association (EHRA). Methods results Eighty-three international experts met Münster for 2 days September 2023. Key findings...

10.1093/europace/euae070 article EN cc-by-nc EP Europace 2024-03-22

Objective Atrial fibrillation (AF) often progresses from paroxysmal AF (PAF) to more permanent forms. To improve personalised medicine, we aim develop a new progression risk prediction model in patients with PAF. Methods In this interim-analysis of the Reappraisal AF: Interaction Between HyperCoagulability, Electrical Remodelling, and Vascular Destabilisation Progression study, PAF undergoing extensive phenotyping at baseline continuous rhythm monitoring during follow-up ≥1 year were...

10.1136/heartjnl-2022-321027 article EN cc-by Heart 2022-07-20

Atrial fibrillation (AF) often starts as a paroxysmal self-terminating arrhythmia. Limited information is available on AF patterns and episode duration of AF. In patients, we longitudinally studied the temporal patterns, association with clinical characteristics, prevalence progression.In this interim analysis Reappraisal AF: Interaction Between HyperCoagulability, Electrical Remodelling, Vascular Destabilisation in Progression (RACE V) registry, 202 patients were followed continuous rhythm...

10.1093/europace/euaa123 article EN cc-by-nc EP Europace 2020-05-09

Abstract Aims The risk of developing atrial fibrillation (AF) and its complications continues to increase, despite good progress in preventing AF-related strokes. Methods results This article summarizes the outcomes 7th Consensus Conference Atrial Fibrillation NETwork (AFNET) European Heart Rhythm Association (EHRA) held Lisbon March 2019. Sixty-five international AF specialists met present new data find consensus on pressing issues prevention, management future research improve care for...

10.1093/europace/euaa279 article EN EP Europace 2020-11-28

Atrial fibrillation (AF) progression is associated with adverse outcome, but the role of circadian or diurnal pattern AF onset remains unclear. We aim to assess association between time episodes clinical phenotype and in patients self-terminating AF.The Reappraisal AF: Interaction Between Hypercoagulability, Electrical Remodelling, Vascular Destabilization Progression study included who underwent extensive phenotyping at baseline continuous rhythm monitoring an implantable loop recorder...

10.1093/europace/euad058 article EN cc-by-nc EP Europace 2023-03-27

Background— The aim of this prospective randomized study was to assess whether an early reablation superior antiarrhythmic drug (AAD) therapy in patients with previous failed pulmonary vein isolation. Methods and Results— Patients paroxysmal atrial fibrillation (AF) eligible for AAD or after a previously initial isolation procedure were followed up 3 years rhythm by means implanted cardiac monitor. After the blanking period postablation, 154 had symptomatic AF recurrences (n=77) repulmonary...

10.1161/circep.113.000495 article EN Circulation Arrhythmia and Electrophysiology 2013-06-08

The number of patients with cardiac implantable electronic device (CIED) is increasing, creating a substantial workload for clinics.This study aims to characterize the workflow and quantify clinic staff time requirements managing CIEDs.A motion evaluation was performed in 11 US European CIEDs clinics. Workflow tasks were repeatedly timed during 1 business week observation at each clinic; these observations included all models manufacturers. mean cumulative required review remote transmission...

10.2196/27720 article EN cc-by JMIR Cardio 2021-06-01

Multimorbidity is common among patients with atrial fibrillation (AF) and associated worse outcomes. We aimed to investigate the association between multimorbidity, AF progression symptom severity in paroxysmal AF. The RACE V (Reappraisal of AF: Interaction Between Hypercoagulability, Electrical Remodeling, Vascular Destabilization Progression AF) study included continuous rhythm monitoring. was defined as ≥2 comorbidities (heart failure, hypertension, diabetes, coronary heart disease,...

10.1161/jaha.123.034514 article EN cc-by-nc-nd Journal of the American Heart Association 2025-02-26

AimsCardiac arrhythmias following acute myocardial infarction (AMI) can be associated with major adverse cardiovascular events. Data on the "real incidence" of post-MI are limited. We aimed to determine rate and burden cardiac by use insertable monitors (ICM) in patients preserved left ventricular ejection fraction (LVEF) after AMI.

10.1093/europace/euw344 article EN EP Europace 2016-10-11

This paper describes an integrated six-beam homodyne laser Doppler vibrometry (LDV) system based on a silicon-on-insulator (SOI) full platform technology, with on-chip photo-diodes and phase modulators. Electronics optics are also implemented around the photonic circuit (PIC) to enable simultaneous measurement. Measurement of propagating guided elastic wave in aluminum plate (speed ≈ 909 m/s @ 61.5 kHz) is demonstrated.

10.1364/oe.26.003638 article EN cc-by Optics Express 2018-02-02

The time from carotid to femoral pulse wave propagation (pulse transit (PTT)) is required estimate the carotid–femoral velocity (PWV), a reliable index for evaluating large artery stiffness. In this work, we propose novel, noncontact laser-based technique, named optical vibrocardiography (VCG), PTT synchronous recordings of motion skin on neck and groin. These measurements, which have been demonstrated be related radial displacement underlying blood vessels, were performed 14 healthy...

10.1038/ajh.2008.280 article EN American Journal of Hypertension 2008-09-11

Antiarrhythmic drugs (AADs) for the treatment of atrial fibrillation (AF) are associated with limited efficacy and adverse effects. Inhibition current IKur, absent from ventricle, is expected to be antiarrhythmic, without cardiac effects, particularly ventricular pro-arrhythmic effects.A randomized clinical trial in symptomatic paroxysmal AF patients being considered ablation. The primary endpoint was burden (AFB) as measured by insertable continuous monitoring (ICM) devices. Screened had an...

10.1093/ehjcvp/pvy022 article EN European Heart Journal - Cardiovascular Pharmacotherapy 2018-07-21

Pulse wave velocity (PWV) is a reference measure for aortic stiffness, itself an important biomarker of cardiovascular risk. To enable low-cost and easy-to-use PWV measurement devices that can be used in routine clinical practice, we have designed several handheld sensors using miniaturized laser Doppler vibrometer (LDV) arrays silicon photonics platform. The LDV-based sensor design the signal processing protocol to obtain pulse transit time (PTT) carotid-femoral feasibility study humans,...

10.1364/boe.394921 article EN cc-by Biomedical Optics Express 2020-06-13

There are currently no biomarkers to select cryptogenic stroke (CS) patients for monitoring with insertable cardiac monitors (ICMs), the most effective tool diagnosing atrial fibrillation (AF) in CS. The purpose of this study was assess clinically available as predictors AF.Eligible CS and transient ischaemic attack underwent 12-month ICMs, clinical follow-up biomarker sampling. Levels thromboembolic biomarkers, taken within 14 days from symptom onset, were compared between diagnosed AF (n =...

10.1111/ene.15746 article EN European Journal of Neurology 2023-02-14

In this paper we present a novel, non-invasive measurement system for optical monitoring of the cardiac rate. This method, called vibrocardiography (VCG), is based on use laser Doppler vibrometer velocity displacement skin in correspondence chest wall. We report typical VCG signals measured 4 healthy subject and particular, investigated effect signal position respect to wall as well surface characteristics signal.

10.1117/12.693151 article EN Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE 2006-06-19

Abstract Introduction Catheter ablation of atrial fibrillation (AF) is frequently studied in randomized trials, observational and registry studies. The aim this expert opinion to provide guidance for clinicians industry regarding the development future clinical studies on catheter AF, implement lessons learned from previous studies, promote a higher degree consistency across Background Studies AF may benefit well‐described definitions endpoints consistent methodology documentation outcomes...

10.1111/jce.16443 article EN cc-by-nc-nd Journal of Cardiovascular Electrophysiology 2024-09-25

Laser Doppler vibrometry has been recently applied for non-contact monitoring of the cardiac activity, both in terms rate and heart variability, measuring velocity skin surface chest wall neck (optical vibrocardiography, VCG). To go further insight analysis VCG recordings, this study authors have compared sounds by digital phonocardiography (PCG) with motion on optical VCG, final aim being identification some events mechanics signals. PCG traces were synchronously recorded 10 healthy...

10.1109/iembs.2007.4352949 article EN Conference proceedings 2007-08-01

Single-procedure catheter ablation success rate is as low 52% in atrial fibrillation (AF) patients. This study evaluated the feasibility of using clinical data and heart variability (HRV) features extracted from an implantable cardiac monitor (ICM) to predict recurrences patients prior undergoing for AF. HRV-derived were 500 beats preceding AF onset first 2 min last episode recorded by ICM 74 (67% male; 57 ± 12 years; 26% non-paroxysmal AF; 57% recurrence) before their ablation. Two types...

10.3389/fphys.2021.672896 article EN cc-by Frontiers in Physiology 2021-05-25
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