A5079403494- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Ion channel regulation and function
- Cardiovascular Syncope and Autonomic Disorders
- ECG Monitoring and Analysis
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Aortic Disease and Treatment Approaches
- Receptor Mechanisms and Signaling
- Nuclear Structure and Function
- RNA Research and Splicing
- Medical research and treatments
- Health and Medical Education
- Cardiac Arrest and Resuscitation
- PARP inhibition in cancer therapy
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Melanoma and MAPK Pathways
Sociedad Española de Cardiología
2022-2025
Hospital Clínico San Carlos
2015-2024
Spanish National Centre for Cardiovascular Research
2015-2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2024
Centro de Investigación Biomédica en Red
2017-2024
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2015-2024
Centro de Estudios Andaluces
2016-2021
University of Michigan–Ann Arbor
2010-2019
Instituto de Investigación Sanitaria del Principado de Asturias
2017-2018
Hospital Universitario La Paz
1996-2017
Abstract Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated risk AF-related complications. The aim this document to summarize key outcomes 9th AFNET/EHRA Consensus Conference Atrial Fibrillation NETwork (AFNET) European Heart Rhythm Association (EHRA). Methods results Eighty-three international experts met Münster for 2 days September 2023. Key findings...
Little is known about the mechanisms underlying transition from paroxysmal to persistent atrial fibrillation (AF). In an ovine model of long-standing AF we tested hypothesis that rate electric and structural remodeling, assessed by dominant frequency (DF) changes, determines time at which becomes persistent.Self-sustained was induced tachypacing. Seven sheep were euthanized 11.5±2.3 days after without reversal sinus rhythm; 7 341.3±16.7 AF. sham-operated animals in rhythm for 1 year. DF...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a disease with 3% global mortality. In the absence of effective treatment, controlling risk factors that predispose to is essential reduce 2019 (COVID-19) Large observational studies suggest exercise can all-cause and disease-specific aim this study was analyze influence baseline physical activity level on COVID-19 mortality This retrospective cohort included patients between 18 70 years old, diagnosed...
Background— Dominant frequencies (DFs) of activation are higher in the atria patients with persistent than paroxysmal atrial fibrillation (AF), and left (LA)-to-right (RA) DF gradients have been identified both. However, whether such maintained as long-term AF is established remains unexplored. We aimed at determining vivo time course values from to sheep testing hypothesis that an LA-to-RA difference associated LA drivers AF. Methods Results— was induced using RA tachypacing (n=8)....
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder for which no cure exists. The disease characterized by premature aging and inevitable death in adolescence due to cardiovascular complications. Most HGPS patients carry a heterozygous de novo LMNA c.1824C > T mutation, provokes the expression of dominant-negative mutant protein called progerin. Therapies proven effective HGPS-like mouse models have yielded only modest benefit clinical trials. To overcome gap...
Significance Defective prelamin A processing causes cardiovascular alterations and premature death in Hutchinson–Gilford progeria syndrome (HGPS) patients also occurs during physiological aging. We found overt repolarization abnormalities HGPS at advanced disease stages. Similar were present progeroid Zmpste24 −/− mice, which had cardiomyocytes that exhibited prolonged calcium transient duration reduced sarcoplasmic reticulum loading capacity release, consistent with absence of...
Cardiac optical mapping is the gold standard for measuring complex electrophysiology in ex vivo heart preparations. However, new methods have been elusive. We aimed at developing and validating an experimental method performing cardiac pig models.First, we characterized excitation-ratiometric properties during pacing ventricular fibrillation (VF) of two near-infrared voltage-sensitive dyes (di-4-ANBDQBS/di-4-ANEQ(F)PTEA) optimized imaging blood-perfused tissue (n = 7). Then, optical-fibre...
Abstract Aims Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac pathophysiology poorly understood. We aimed to study the ability of hIAV different pathogenicity infect mouse heart, and establish relationship between infective capacity in vivo, cellular molecular alterations. Methods results evaluated lung heart viral titres mice infected either one several strains inoculated intranasally. 3D reconstructions tissue were used...
Significance Tbx20 is a transcription factor whose critical role in cardiogenesis well-established. Here we functionally analyzed the electrophysiological effects produced by mutation (p.R311C) found some affected individuals belonging to family with long QT syndrome (an inherited cardiac arrhythmia due delayed ventricular repolarization). We demonstrated that selectively increases expression of KCNH2 , which encodes for channel Kv11.1 (hERG) generates main repolarizing current. Conversely,...
Abstract Panoramic optical mapping is the primary method for imaging electrophysiological activity from entire outer surface of Langendorff-perfused hearts. To date, it only simultaneously measuring multiple key parameters, such as transmembrane voltage and intracellular free calcium, at high spatial temporal resolution. Despite impact has already had on fields cardiac arrhythmias whole-heart computational modeling, present-day system designs precludes its adoption by broader cardiovascular...
New remote navigation systems have been developed to improve current limitations of conventional manually guided catheter ablation in complex cardiac substrates such as left atrial flutter. This protocol describes all the clinical and invasive interventional steps performed during a human electrophysiological study assess accuracy, safety real-time Catheter Guidance, Control Imaging (CGCI) system. Patients who underwent right or atrium flutter substrate were included. Specifically, data from...
Blockade of inward-rectifier K+ channels by chloroquine terminates reentry in cholinergic atrial fibrillation (AF). However, it is unknown whether and are also important maintaining stretch-induced AF (SAF). We surmised that underlies SAF, abolishing with SAF more effectively than traditional Na+-channel blockade flecainide.Thirty Langendorff-perfused sheep hearts were exposed to acute continuous stretch, mapped optically electrically. dynamics studied under control during perfusion either...
Costly proprietary panoramic multielectrode (64-256) acquisition systems are being increasingly used together with conventional electroanatomical mapping for persistent atrial fibrillation (PersAF) ablation. However, such approaches target alleged drivers (rotational/focal) regardless of their activation frequency dynamics.To test the hypothesis that stable regions higher than surrounding instantaneous modulation (iFM) drive PersAF and determine whether rotational activity is specific...
Abstract Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related myopathy. This study reports mechanistic insights into electromechanical remodeling process associated with AF progression and further demonstrates its prognostic value clinic. In pigs, sequential assessment shows progressive decrease mechanical activity early dissociation from electrical counterpart. Atrial tissue samples animals reveal an abnormal...
The goal was to terminate atrial fibrillation (AF) by targeting atrioventricular differences in ionic properties.Optical mapping used record electrical activity during carbachol (0.25-0.5 μM)-induced AF pig hearts. atrial-specific current, I(Kur), blocked with 100 μM 4-aminopyridine (4-AP) or 0.5 DPO-1. Hearts and ventricular (VF) were also subjected increasing levels of extracellular K(+) ([K(+)](o): 6-12 mM), compared controls (4 mM). We hypothesized that due the more negative steady-state...
Abstract Aims The transcription factor Tbx5 controls cardiogenesis and drives Scn5a expression in mice. We have identified two variants TBX5 encoding p. D111Y F206L Tbx5, respectively, unrelated patients with structurally normal hearts diagnosed long QT (LQTS) Brugada (BrS) syndrome. Here, we characterized the consequences of each variant to unravel underlying disease mechanisms. Methods results combined clinical analysis vivo vitro electrophysiological molecular techniques human-induced...