A5060579995- Alzheimer's disease research and treatments
- RNA Research and Splicing
- Cholinesterase and Neurodegenerative Diseases
- Bone health and osteoporosis research
- Insect Resistance and Genetics
- Cellular transport and secretion
- Craniofacial Disorders and Treatments
- Transplantation: Methods and Outcomes
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- PARP inhibition in cancer therapy
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Nuclear Structure and Function
- MicroRNA in disease regulation
- Medical and Biological Sciences
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
- Angiogenesis and VEGF in Cancer
Aarhus University
2019-2024
Lillebaelt Hospital
2017
University of Southern Denmark
2017
Aarhus University Hospital
2014
It is well known that bone remodeling starts with a resorption event and ends formation. However, what happens in between how formation are coupled remains mostly unknown. Remodeling achieved by so-called basic multicellular units (BMUs), which local teams of osteoclasts, osteoblasts, reversal cells recently proven identical osteoprogenitors. Their organization within BMU cannot be appropriately analyzed common histology. The originality the present study to capture events ranging from...
Summary Mutations in DNMT 3A , the gene encoding DNA methyltransferase 3 alpha, have been identified as molecular drivers acute myeloid leukaemia ( AML ) with possible implications for minimal residual disease monitoring and prognosis. To further explore utility of mutations biomarkers we developed assays sensitive detection recurrent affecting residue R882. Analysis from 298 diagnostic samples revealed 45 cases (15%), which coincided NPM 1 FLT IDH . were stable 12 13 patients presenting...
The established causal genes in Alzheimer's disease (AD), APP, PSEN1, and PSEN2, are functionally characterized using biomarkers, capturing an vivo profile reflecting the disease's initial preclinical phase. Mutations SORL1, encoding endosome recycling receptor SORLA, found 2%–3% of individuals with early-onset AD, SORL1 haploinsufficiency appears to be for AD. To test whether can function as AD gene, we use CRISPR-Cas9-based gene editing develop a model Göttingen minipigs, taking advantage...
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder for which no cure exists. The disease characterized by premature aging and inevitable death in adolescence due to cardiovascular complications. Most HGPS patients carry a heterozygous de novo LMNA c.1824C > T mutation, provokes the expression of dominant-negative mutant protein called progerin. Therapies proven effective HGPS-like mouse models have yielded only modest benefit clinical trials. To overcome gap...
Background and aimsSmooth muscle cell (SMC) lineage cells in atherosclerosis flow cessation-induced neointima are oligoclonal, being recruited from a tiny fraction of medial SMCs that modulate proliferate. The present study aimed to investigate the clonal structure SMC healing more severe arterial injury.MethodsArterial injury (wire, stretch, partial ligation) was inflicted on right carotid artery mice with homozygous, SMC-restricted, stochastically recombining reporter transgenes produced...
ABSTRACT Multiple myeloma (MM) is a haematological malignancy with abnormal proliferation of plasma cells in the bone marrow (BM), and MM patients highly proliferative have reduced overall survival. Circular RNAs (circRNAs) are endogenous, non‐coding molecules that promising biomarkers cancer. Here, we present largest study circRNAs to date explore prognostic potential link between circRNA expression MM. We performed deep total RNA sequencing (RNA‐seq) on two cohorts: one cohort consisting...
ABSTRACT The few established causal genes in Alzheimer’s disease (AD), mutations APP and PSENs, have been functionally characterized using biomarkers, capturing an vivo profile reflecting the disease’s initial preclinical phase. SORL1 , a gene encoding endosome recycling receptor SORLA, epidemiologically behaves as when truncating lead to partial loss of protein function. Here, effort test whether can indeed function AD gene, we used CRISPR-Cas9-based editing develop novel model...
The few established causal genes in Alzheimer’s disease (AD), mutations APP and PSENs, have been functionally characterized using biomarkers, capturing an vivo profile reflecting the disease’s initial preclinical phase. SORL1, a gene encoding endosome recycling receptor SORLA, epidemiologically behaves as when truncating lead to partial loss of protein function. Here, effort test whether SORL1 can indeed function AD gene, we used CRISPR-Cas9-based editing develop novel model...