A5100414387- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- RNA Research and Splicing
- Developmental Biology and Gene Regulation
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Animal Nutrition and Physiology
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Microbial Metabolic Engineering and Bioproduction
- Electromagnetic Fields and Biological Effects
- Magnetic and Electromagnetic Effects
- Spaceflight effects on biology
- Polysaccharides and Plant Cell Walls
- DNA and Nucleic Acid Chemistry
- Axon Guidance and Neuronal Signaling
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Fungal Biology and Applications
- Cell Adhesion Molecules Research
- Erythrocyte Function and Pathophysiology
First People's Hospital of Chongqing
2025
Chongqing University
2025
West China Hospital of Sichuan University
2025
Sichuan University
2025
Shanghai University of Traditional Chinese Medicine
2023-2025
China Agricultural University
2021-2025
Jiangmen Central Hospital
2025
Shanghai Traditional Chinese Medicine Hospital
2025
Anshan Hospital
2025
Xinjiang University
2024
Brain glucose metabolism is impaired in Alzheimer's disease (AD), the most common form of dementia. Type 2 diabetes mellitus (T2DM) reported to increase risk for dementia, including AD, but underlying mechanism not understood. Here, we investigated brain insulin-PI3K-AKT signalling pathway autopsied frontal cortices from nine 10 T2DM, eight T2DM-AD and seven control cases. We found decreases levels activities several components AD T2DM The deficiency was more severe individuals with both...
Brain glucose uptake/metabolism is impaired in Alzheimer disease (AD). Here, we report that levels of the two major brain transporters (GLUT1 and GLUT3) responsible for uptake into neurons were decreased AD brain. This decrease correlated to O ‐GlcNAcylation, hyperphosphorylation tau, density neurofibrillary tangles human brains. We also found down‐regulation hypoxia‐inducible factor 1, a regulator GLUT1 GLUT3, These studies provide possible mechanism by which GLUT3 deficiency could cause...
Abstract Harvesting biomechanical energy from cardiac motion is an attractive power source for implantable bioelectronic devices. Here, we report a battery-free, transcatheter, self-powered intracardiac pacemaker based on the coupled effect of triboelectrification and electrostatic induction treatment arrhythmia in large animal models. We show that capsule-shaped device (1.75 g, 1.52 cc) can be integrated with delivery catheter implanting right ventricle swine through intravenous route,...
SARS 3C-like proteinase has been proposed to be a key enzyme for drug design against SARS. Lack of suitable assay major hindrance kinetic studies and large-scale inhibitor screen 3CL proteinase. Since belongs the cysteine protease family (family C3 in clan CB) with chymotrypsin fold, it is important understand catalytic mechanism determine whether proteolysis proceeds through general base catalysis like or an ion pair papain. We have established continuous colorimetric applied study...
β-Amyloid (Aβ) pathology is an essential pathogenic component in Alzheimer's disease (AD). However, the significance of Aβ pathology, including deposits/oligomers and glial reactions, to neurodegeneration unclear. In particular, despite neurotoxicity indicated by vitro studies, mouse models with significant deposition lack robust progressive loss forebrain neurons. Such results have fueled view that insufficient for vivo . this study, because monoaminergic (MAergic) neurons show degenerative...
Type 2 diabetes mellitus (T2DM) increases the risk for Alzheimer's disease (AD), but underlying mechanism is unknown. In this study, we determined levels of major brain glucose transporters, O-GlcNAcylation and phosphorylation tau in postmortem tissue from frontal cortices 7 controls, 11 T2DM subjects, 10 AD subjects 8 additional who had both AD. We found that neuronal transporter 3 was decreased to a bigger extent than brain. The global proteins were also as seen Phosphorylation at some...
Abstract Tau is a neuronal microtubule‐associated protein. Its hyperphosphorylation plays critical role in Alzheimer disease (AD). Expression and phosphorylation of tau are regulated developmentally, but its dynamic regulation the responsible kinases or phosphatases remain elusive. Here, we studied developmental rats during development from embryonic day 15 through age 24 months. We found that expression increased sharply stage then became relatively stable, whereas was much higher...
Background We have demonstrated that T lymphoma invasion and metastasis 1 (Tiam1) gene is associated with the poor prognosis of patients hepatocellular carcinoma (HCC), we used a computational approach to identify miR-141 as Tiam1-targeting microRNA (miRNA). Here, explored function relationship between Tiam1 in HCC. Methods The expression HCC tissues cell lines was detected its roles regulation proliferation, migration target investigated. identified novel miR-141. Ethics statement: our...
Abstract The RNA-binding protein QKI belongs to the hnRNP K-homology domain family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Qki found highly expressed in developing adult hearts. By employing human embryonic stem cell (hESC) cardiomyocyte differentiation system generating QKI-deficient hESCs (hESCs- del ) using CRISPR/Cas9 gene editing technology, we analyze physiological role differentiation, maturation,...
Abstract Stress granules (SGs) fulfill a pivotal role in host defense mechanisms, by sequestering both mRNA and protein via the process of liquid–liquid phase separation (LLPS). In this study, we showed that perillaldehyde (PAE), natural occurring compound, bound directly to core SGs, Ras GTPase‐activating protein‐binding 1/2 (G3BP1/2), thereby inducing assembly SGs through LLPS G3BP/RNA complexes vitro. Moreover, Parkinson's disease (PD) models using Caenorhabditis elegans ( C. ) mice, PAE...
HOX proteins and some orphan homeodomain form complexes with either PBX or MEIS subclasses of proteins. This interaction can increase the binding specificity transcriptional effectiveness partner. Here we show that specific members both a multimeric complex pancreatic protein PDX1 switch nature its activity. The two activities are exhibited through 10-bp B element enhancer elastase I gene (ELA1). In acinar cells activity requires other elements ELA1 enhancer; in β-cells activate promoter...