A5101519630- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Neurological disorders and treatments
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Muscle activation and electromyography studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Traditional and Medicinal Uses of Annonaceae
- Advanced MRI Techniques and Applications
- Advanced Sensor and Energy Harvesting Materials
- Phytochemical compounds biological activities
- Lung Cancer Diagnosis and Treatment
- Synthetic Organic Chemistry Methods
- Cardiovascular and exercise physiology
- Sports injuries and prevention
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Transplantation: Methods and Outcomes
- Neuroscience and Neural Engineering
- Catalytic C–H Functionalization Methods
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Chongqing University
2025
Nanjing Medical University
2025
Fu Wai Hospital
2020-2021
Southern Medical University
2020
Nanfang Hospital
2020
Peking Union Medical College Hospital
2020
Hangzhou Cancer Hospital
2019
Zero to Three
2017
Creative Commons
2017
Bioresorbable electronics that can be absorbed and become part of the organism after their service life are a new trend to avoid secondary invasive surgery. However, material limitation is significant challenge. There fewer biodegradable materials with pressure-sensitive properties. Here, pressure sensor based on triboelectric effect between bioabsorbable reported. This available in almost all materials. The bioresorbable (BTS) directly convert ambient changes into electrical signals. device...
Abstract Harvesting biomechanical energy from cardiac motion is an attractive power source for implantable bioelectronic devices. Here, we report a battery-free, transcatheter, self-powered intracardiac pacemaker based on the coupled effect of triboelectrification and electrostatic induction treatment arrhythmia in large animal models. We show that capsule-shaped device (1.75 g, 1.52 cc) can be integrated with delivery catheter implanting right ventricle swine through intravenous route,...
Arrhythmogenic cardiomyopathy (AC) shows large heterogeneity in its clinical, genetic, and pathological presentation. This study aims to provide a comprehensive atlas of end-stage AC illustrate the relationships among clinical characteristics, genotype, profiles patients with this disease.We collected 60 explanted hearts performed standard pathology examinations. The characteristics patients, their genotype cardiac magnetic resonance imaging findings were assessed along characteristics....
Abstract Background The evidence on the association between triglyceride glucose (TyG) index and risk of death in general population remains controversial. This study aims to investigate relationship TyG all-cause cardiovascular mortality population, with a focus sex differences. Methods prospective cohort analyzed data from National Health Nutrition Examination Survey (1999–2002), comprising 7,851 US adults. employed multivariate Cox proportional hazards regression two-segment hazard models...
Abstract Background and Objectives Left bundle branch area pacing (LBBAP) has developed as a strategy for patients with pacing‐induced cardiomyopathy (PICM). We aimed to compare the upgrade effectiveness between LBBAP traditional biventricular (BVP) in PICM patients. Methods Consecutive successful device upgrades were enrolled. The primary outcome was echocardiographic response, defined absolute left ventricular ejection fraction (LVEF) improvement ≥5% at 6‐month follow up. Results A total...
Urinary incontinence (UI), as one of the five major global diseases, has seen a continuous rise in incidence, resulting significant medical costs and societal burden. The American Heart Association (AHA) established criteria ideal cardiovascular health (CVH). Life's Essential 8 (LE8) score to reduce risk mortality. UI shares several common factors with diseases (CVDs). This study aimed investigate association between LE8 incidence UI, extending impact CVH. We examined data from National...
His bundle pacing (HBP) is the most physiological modality. However, HBP has longer procedure times with frequent high capture thresholds, which likely contributes to low adoption of this approach. The aim study compare implantation a novel imaging technique versus standard technique.This included 50 patients indications randomized visualization tricuspid valve annulus (N=25, group) or method control group). In group, was imaged by contrast injection in right ventricle during fluoroscopy....
Dilated cardiomyopathy (DCM) and ischemic (ICM) are common causes of heart failure (HF). Though they share similar clinical characteristics, their differential effects on cardiovascular metabolomics have yet to be elucidated. In this study, we applied a comprehensive platform plasma samples HF patients with different etiology (38 DCM 18 ICM) 20 healthy controls. Significant differences in profiling were shown among two groups 233 dysregulated metabolites identified between versus controls,...
Abstract Background The prognostic value of triglyceride-glucose (TyG) index is not yet known for older diabetic patients received right ventricular pacing (RVP). We aimed to investigate the association between TyG and risk heart failure hospitalization (HFH) in RVP. Methods This study was conducted January 2017 2018 at Fuwai Hospital, Beijing, China, included (age ≥ 65 years) that RVP first time. were obtained before implantation. primary endpoint HFH. Results A total 231 divided into three...
Non-nucleoside tandem derivatives: Potent hepatitis B antiviral activity is established for 2,2′-bisthiazole heterocyclic derivatives. The core structure of these compounds differs from those known non-nucleoside agents, constituting a new direction in virus drug development.
Abstract Background His bundle pacing (HBP) is a physiological modality, but HBP implantation remains challenge. Objective This study explored the feasibility of using visualization tricuspid valve annulus (TVA) to locate site for HBP. Methods During lead placement in eight patients with symptomatic bradycardia, TVA and septal leaflet was revealed by contrast injection right ventricle under fluoroscopic anterior oblique view, target identified near intersection interventricular septum. On...
Introduction: For patients who develop atrioventricular block (AVB) following transcatheter aortic valve replacement (TAVR), right ventricular pacing (RVP) may be associated with adverse outcomes. We assessed the feasibility of conduction system (CSP) in developed AVB TAVR and compared procedural clinical outcomes RVP. Methods: Consecutive were prospectively enrolled, implanted RVP or CSP. Procedural among different modalities. Results: A total 60 including 10 His bundle (HBP), 20 left...
Clinical trials have demonstrated that cardiac resynchronization therapy (CRT) is effective in patients with "non-ischemic cardiomyopathy". However, dilated-phase hypertrophic cardiomyopathy (DHCM) been generally excluded from such trials. We aimed to compare the clinical outcome of CRT DHCM, idiopathic dilated (IDCM), or ischemic (ICM).A total 312 consecutive (DHCM: n = 16; IDCM: 231; ICM: 65) undergoing Fuwai hospital were studied respectively. Response was defined as reduction left...
The first total synthesis of aphadilactones A-D, diastereomeric natural products recently isolated from the Meliaceae plant Aphanamixis grandifolia by Yue and co-workers, which possess an unprecedented carbon skeleton, has been achieved. features a catalytic asymmetric hetero-Diels-Alder reaction to form dihydropyran ring, concurrent installation lactone furan moieties via tandem acid-catalyzed acetal cleavage, oxidation, cyclization process, intermolecular Diels-Alder forge target products.
This study aimed to develop and validate a competing risk nomogram for predicting all-cause mortality heart transplantation (HT) before first appropriate shock in non-ischaemic dilated cardiomyopathy (DCM) patients receiving implantable cardioverter-defibrillators (ICD).A total of 218 consecutive DCM implanted with ICD between 2010 2019 at our institution were retrospectively enrolled. Cox proportional hazards model was primarily built identify variables associated death HT. Then, Fine-Gray...
Background: The relationship between short-term cardiac function changes and long-term outcomes in heart failure (HF) patients undergoing resynchronization therapy (CRT) remains uncertain, especially when stratified by diabetes status. Objectives: This study aims to assess the association such as all-cause mortality HF hospitalization CRT, Design: is a cohort longitudinal retrospective study. Methods: A total of 666 patients, treated with CRT March 2007 2019, were included this Among them,...
The prognostic value of preimplantation nutritional status is not yet known for older diabetic patients that received right ventricular pacing (RVP). study aimed to investigate the clinical four malnutrition screening tools prediction heart failure hospitalization (HFH) in RVP. Retrospective observational cohort study. This was conducted between January 2017 and 2018 at Fuwai Hospital, Beijing, China, included (age ≥ 65 years) RVP first time Prognostic Nutritional Index (PNI), Geriatric Risk...
Key Teaching Points•The KODEX-EPD cardiac imaging and navigation system (EPD Solutions, Philips, Best, The Netherlands) is a novel noncontact type of mapping system.•Without an electrophysiological catheter, this electromagnetic-based allows real-time visualization intracardiac catheters as well display images in number different formats.•The provides alternative, extremely lower fluoroscopic approach for His bundle pacing. •The