A5010939026- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Neurological disorders and treatments
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Cardiac Arrest and Resuscitation
- Advanced MRI Techniques and Applications
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Cardiac Valve Diseases and Treatments
- Neuroscience and Neural Engineering
- Cardiovascular Effects of Exercise
- Muscle activation and electromyography studies
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Immunology Research
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- Ion channel regulation and function
- Antiplatelet Therapy and Cardiovascular Diseases
Medical University of South Carolina
2016-2025
Virginia Commonwealth University Medical Center
2010-2023
Heart Rhythm Society
2020-2023
Twitter (United States)
2022
Harvard University
1991-2021
Baylor University
2021
Beth Israel Deaconess Medical Center
2002-2021
Miriam Hospital
2021
Gold Skin Care Center
2020-2021
Barzilai Medical Center
2020-2021
One quarter of strokes are unknown cause, and subclinical atrial fibrillation may be a common etiologic factor. Pacemakers can detect episodes rapid rate, which correlate with electrocardiographically documented fibrillation. We evaluated whether rate detected by implanted devices were associated an increased risk ischemic stroke in patients who did not have other evidence fibrillation.We enrolled 2580 patients, 65 years age or older, hypertension no history fibrillation, whom pacemaker...
This study aimed to determine whether QRS morphology identifies patients who benefit from cardiac resynchronization therapy with a defibrillator (CRT-D) and it influences the risk of primary secondary end points in enrolled Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT) trial.Baseline 12-lead ECGs were evaluated regard morphology. Heart failure event or death was point trial. Death, heart event, ventricular tachycardia, fibrillation...
Background— Among patients with implantable pacemakers and defibrillators, subclinical atrial fibrillation (SCAF) is associated an increased risk of stroke; however, there limited understanding their temporal relationship. Methods Results— The Asymptomatic Atrial Fibrillation Stroke Evaluation in Pacemaker Patients the Reduction Pacing Trial (ASSERT) enrolled 2580 pacemaker defibrillator aged ≥65 years a history hypertension but without fibrillation. Pacemakers cardioverter-defibrillators...
The mortality rate among patients with coronary artery disease, abnormal ventricular function, and unsustained tachycardia is high. usefulness of electrophysiologic testing for risk stratification in these unclear.
ASSERT demonstrated that subclinical atrial fibrillation (SCAF) is common in pacemaker patients without prior AF and associated with increased risk of ischemic stroke or systemic embolism. SCAF episodes vary duration little known about the incidence different durations SCAF, their prognosis.ASSERT followed 2580 receiving a ICD, aged >65 years hypertension, AF. The effect on subsequent embolism was evaluated time-dependent covariate Cox models. Patients whom longest ≤6 min were excluded from...
Background— The most frequent complications associated with implantable cardioverter-defibrillators (ICDs) involve the transvenous leads. A subcutaneous cardioverter-defibrillator (S-ICD) has been developed as an alternative system. This study evaluated safety and effectiveness of S-ICD System (Cameron Health/Boston Scientific) for treatment life-threatening ventricular arrhythmias (ventricular tachycardia/ventricular fibrillation). Methods Results— prospective, nonrandomized, multicenter...
The entirely subcutaneous implantable cardioverter-defibrillator (S-ICD) is the first defibrillator that avoids placing electrodes in or around heart. Two large prospective studies (IDE [S-ICD System IDE Clinical Investigation] and EFFORTLESS [Boston Scientific Post Market S-ICD Registry]) have reported 6-month to 1-year data on S-ICD. objective of this study was evaluate safety efficacy a diverse population. Data from were pooled. Shocks independently adjudicated, complications measured...
Background One variable that may influence cardiac resynchronization therapy response is the programmed atrioventricular (AV) delay. The SmartDelay Determined AV Optimization: A Comparison to Other Delay Methods Used in Cardiac Resynchronization Therapy (SMART-AV) Trial prospectively randomized patients a fixed empirical delay (120 milliseconds), echocardiographically optimized delay, or with SmartDelay, an electrogram-based algorithm. and Results total of 1014 (68% men; mean age, 66±11...
The aim of the present study was to evaluate relationship between left ventricular (LV) electrical delay, as measured by QLV interval, and outcomes in a prospectively designed substudy SMART-AV Trial. This multicentre patients with advanced heart failure undergoing cardiac resynchronization therapy (CRT) defibrillator implantation. In 426 subjects, interval from onset QRS surface ECG first large peak LV electrogram. Left volumes were echocardiography at baseline after 6 months CRT blinded...
Background— Cardiac resynchronization therapy (CRT) decreases mortality, improves functional status, and induces reverse left ventricular remodeling in selected populations with heart failure. We aimed to assess the impact of baseline QRS duration morphology change pacing on CRT outcomes mild Methods Results— Resynchronization Reverses Remodeling Systolic Left Ventricular Dysfunction (REVERSE) was a multicenter randomized trial among 610 patients Baseline CRT-paced durations were evaluated...