A5003758535- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Sports injuries and prevention
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Congenital heart defects research
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
- Venous Thromboembolism Diagnosis and Management
Montreal Heart Institute
2016-2025
Université de Montréal
2016-2025
Western University
2000-2024
University of Ottawa
2001-2024
Royal Jubilee Hospital
2024
Dalhousie University
2024
University of Alberta
2024
Calgary Laboratory Services
2011-2017
Washington University in St. Louis
2017
Leiden University
2017
Vitamin K antagonists have been shown to prevent stroke in patients with atrial fibrillation. However, many are not suitable candidates for or unwilling receive vitamin antagonist therapy, and these a high risk of stroke. Apixaban, novel factor Xa inhibitor, may be an alternative treatment such patients.In double-blind study, we randomly assigned 5599 fibrillation who were at increased whom therapy was unsuitable apixaban (at dose 5 mg twice daily) aspirin (81 324 per day), determine whether...
Cardiac-resynchronization therapy (CRT) benefits patients with left ventricular systolic dysfunction and a wide QRS complex. Most of these are candidates for an implantable cardioverter-defibrillator (ICD). We evaluated whether adding CRT to ICD optimal medical might reduce mortality morbidity among such patients.We randomly assigned New York Heart Association (NYHA) class II or III heart failure, ejection fraction 30% less, intrinsic duration 120 msec more paced 200 receive either alone...
Background We previously reported that major depression in patients the hospital after a myocardial infarction (MI) substantially increases risk of mortality during first 6 months. examined impact over 18 months and present additional evidence concerning potential mechanisms linking mortality. Methods Results Two-hundred twenty-two responded to modified version National Institute Mental Health Diagnostic Interview Schedule (DIS) for depressive episode at approximately 7 days MI. The Beck...
It is common practice to restore and maintain sinus rhythm in patients with atrial fibrillation heart failure. This approach based part on data indicating that a predictor of death failure suggesting the suppression may favorably affect outcome. However, benefits risks this have not been adequately studied.We conducted multicenter, randomized trial comparing maintenance (rhythm control) control ventricular rate (rate left ejection fraction 35% or less, symptoms congestive failure, history...
Patients with heart failure who receive an implantable cardioverter-defibrillator (ICD) for primary prevention (i.e., of a first life-threatening arrhythmic event) may later therapeutic shocks from the ICD. Information about long-term prognosis after ICD therapy in such patients is limited.Of 829 were randomly assigned to therapy, we implanted 811. that followed onset ventricular tachycardia or fibrillation considered be appropriate. All other inappropriate.Over median follow-up period 45.5...
The restoration and maintenance of sinus rhythm is a desirable goal in patients with atrial fibrillation, because the prevention recurrences can improve cardiac function relieve symptoms. Uncontrolled studies have suggested that amiodarone low doses may be more effective safer than other agents preventing recurrence, but this agent has not been tested large, randomized trial.
Evidence suggests that physiologic pacing (dual-chamber or atrial) may be superior to single-chamber (ventricular) because it is associated with lower risks of atrial fibrillation, stroke, and death. These benefits have not been evaluated in a large, randomized, controlled trial.At 32 Canadian centers, patients without chronic fibrillation who were scheduled for first implantation pacemaker treat symptomatic bradycardia eligible enrollment. We randomly assigned receive either ventricular...
Background — Although previous research demonstrated an independent link between depression symptoms and cardiac mortality after myocardial infarction (MI), was assessed only once, a dose-response relationship not evaluated. Methods Results We administered the Beck Depression Inventory to 896 post-MI patients during admission at 1 year. Five-year survival ascertained using Medicare data. observed significant long-term hospitalization mortality. remained control for multiple measures of...
Background —We previously reported that depression after myocardial infarction (MI) increases the long-term risk of cardiac mortality. Other research suggests social support may also influence prognosis. This article examines interrelationships between baseline and in terms prognosis changes symptoms over first post-MI year. Methods Results —For this study, 887 patients completed Beck Depression Inventory (BDI) Perceived Social Support Scale (PSSS) at about 7 days MI. Some 32% had BDIs ≥10,...
The mortality rate among patients with coronary artery disease, abnormal ventricular function, and unsustained tachycardia is high. usefulness of electrophysiologic testing for risk stratification in these unclear.
Objective The purpose of this study was to assess gender differences in the impact depression on 1-year cardiac mortality patients hospitalized for an acute myocardial infarction (MI). Methods Secondary analysis performed data from two studies that used Beck Depression Inventory (BDI) symptoms during hospitalization: a prospective post-MI risk and randomized trial psychosocial intervention (control group only). sample included 896 (283 women) who survived discharge received usual...
The prevalence and prognostic impact of previous depression, depression in the hospital, after discharge were studied 222 patients admitted for acute myocardial infarction (MI).Patients interviewed 1 week, 6 months, 12 months index MI using a modified version Diagnostic Interview Schedule (DIS); also completed Beck Depression Inventory (BDI). Patients or family members recontacted at 18 to determine survival. Some 27.5% had least one episode major before their MI, but only 7.7% depressed...
Rapid atrial activation causes electrical remodeling that promotes fibrillation (AF), but underlying mechanisms are incompletely understood. We applied epicardial mapping to evaluate electrophysiology and AF duration in dogs subjected rapid pacing (400/min).Dogs paced for 1 (P1, n=7), 7 (P7, n=13), or 42 (P42, n=7) days were compared with sham (P0, n=13). Atrial progressively increased duration. effective refractory period (ERP) ERP accommodation rate significantly decreased by pacing,...
This study examine the importance of major depression symptoms, history depression, anxiety, anger-in, anger-out, and perceived social support, measured in hospital after a myocardial infarction (MI), predicting cardiac events over subsequent 12 months sample 222 patients. Cardiac included both recurrences acute coronary syndromes (unstable angina admissions survived nonsurvived MI recurrences) probable arrhythmic (survived arrests deaths). Major depressive all significantly predicted...
X-VeRT is the first prospective randomized trial of a novel oral anticoagulant in patients with atrial fibrillation undergoing elective cardioversion. We assigned 1504 to rivaroxaban (20 mg once daily, 15 if creatinine clearance was between 30 and 49 mL/min) or dose-adjusted vitamin K antagonists (VKAs) 2:1 ratio. Investigators selected either an early (target period 1–5 days after randomization) delayed (3–8 weeks) cardioversion strategy. The primary efficacy outcome composite stroke,...
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients.Five hundred twenty-eight patients with definite diagnosis no history sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries North America Europe. Over 4.83 (interquartile range 2.44-9.33) years follow-up, 146 (27.7%)...
Background— During follow-up of between 1 and 3 years in the Randomized Evaluation Long-term Anticoagulation Therapy (RE-LY) trial, 2 doses dabigatran etexilate were shown to be effective safe for prevention stroke or systemic embolism patients with atrial fibrillation. There is a need longer-term on further data comparing doses. Methods Results— Patients randomly assigned RE-LY eligible Multicenter Extension Dabigatran Treatment Atrial Fibrillation (RELY-ABLE) trial if they had not...