A5007151148- IL-33, ST2, and ILC Pathways
- Mechanical Engineering and Vibrations Research
- Engineering Structural Analysis Methods
- Atrial Fibrillation Management and Outcomes
- Eosinophilic Esophagitis
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Electronic Packaging and Soldering Technologies
- MicroRNA in disease regulation
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Protease and Inhibitor Mechanisms
- Cardiovascular Disease and Adiposity
- Mechanical stress and fatigue analysis
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Engineering Applied Research
- GDF15 and Related Biomarkers
- Cerebrovascular and Carotid Artery Diseases
- Platelet Disorders and Treatments
Medical University of Vienna
2016-2025
Univerzitetski Klinički Centar Srbije
2024
Ludwig Boltzmann Institute for Cancer Research
2021
Ludwig Boltzmann Institute for Digital Health and Prevention
2021
Centar za Promociju Nauke
2018-2020
Ludwig Boltzmann Cluster for Cardiovascular Research
2014-2018
Private University in the Principality of Liechtenstein
2018
Federal Almazov North-West Medical Research Centre
2018
Union Hospital
2017
Universität für Weiterbildung Krems
2017
Using proteomics, we aimed to reveal molecular types of human atherosclerotic lesions and study their associations with histology, imaging, cardiovascular outcomes.
Abstract Tissue factor (TF) is the primary trigger of coagulation. Elevated levels TF are found in atherosclerotic plaques and leads to thrombus formation when released upon plaque rupture. Interleukin (IL)-33 was previously shown induce angiogenesis inflammatory activation endothelial cells (ECs). Here, we investigated impact IL-33 on human ECs, as a possible new link between inflammation induced mRNA protein umbilical vein ECs coronary artery ECs. IL-33-induced expression ST2-...
Background: Pulsed field ablation [PFA] is a novel technique for pulmonary vein isolation [PVI] in patients with paroxysmal and persistent atrial fibrillation. However, data the efficacy safety of PFA left substrate modification using single shot system, long-standing fibrillation [AF] macro- as well micro-reentrant tachycardia [LAMRT], are scarce. Here, we provide small, single-center case series regarding single-shot system. Methods: Nine AF LAMRT underwent redo-PVI Patients were...
Neutrophil gelatinase-associated lipocalin (NGAL), an acute phase protein released by neutrophils, has been described as biomarker of inflammatory states. Type 2 diabetes mellitus (T2DM) is characterized increased inflammation and elevated risk for embolization carotid artery stenosis (CAS). We aimed to explore the role NGAL systemically in plaques diabetics undergoing endarterectomy. Moreover, potential anti-inflammatory effect metformin on was addressed diabetics. Serum matrix...
Neutrophil gelatinase associated lipocalin (NGAL) is expressed in atherosclerotic lesions and was recently implicated the pathogenesis of cardiovascular pathologies. Statins are known to exert stabilizing effects on plaque. The aims our study were (1) investigate association serum NGAL metalloproteinase (MMP)-9/NGAL complex with vulnerability plaque, (2) reveal statin treatment circulating MMP-9/NGAL levels patients carotid artery stenosis.We examined blood samples from 136 stenosis by...
Monocytes and monocyte-derived microvesicles (MVs) are the main source of circulating tissue factor (TF). Increased monocyte TF expression increased levels procoagulant MVs contribute to formation a prothrombotic state in patients with cardiovascular disease. Interleukin (IL)-33 is pro-inflammatory cytokine involved atherosclerosis other inflammatory diseases, but its role regulating thrombosis still unclear. The aim present study was investigate effects IL-33 on properties human monocytes...
Endothelial cells (ECs) are major modulators of hemostasis by expressing and releasing pro- anticoagulant mediators into the circulation. Previous studies showed that cultured ECs release procoagulant cell culture supernatants as evidenced reduction viscoelastic clotting time. This effect was reversed with an anti-tissue factor antibody. Here, we aimed to investigate whether tissue (TF) released endothelial-derived extracellular vesicles (EVs) which portion displays most prominent...
Macrophages are versatile immune cells capable of polarizing into functional subsets depending on environmental stimulation. In atherosclerotic lesions, proinflammatory polarized macrophages associated with symptomatic plaques, whereas Th2 (T-helper cell type 2) cytokine-polarized inversely related disease progression. To establish a cause for these observations, we analyzed extracellular matrix degradation phenotypes in macrophages.
Growth differentiation factor (GDF)-15 and soluble ST2 (sST2) are established prognostic markers in acute chronic heart failure. Assessment of these biomarkers might improve arrhythmic risk stratification patients with non-ischaemic, dilated cardiomyopathy (DCM) based on left ventricular ejection fraction (LVEF). We studied the value GDF-15 sST2 for prediction death (AD) all-cause mortality DCM. prospectively enrolled 52 DCM LVEF ≤ 50%. Primary end-points were time to AD or resuscitated...
Neutrophil extracellular traps (NETs) are supposed to play a central role in atherothrombosis. We measured circulating citrullinated histone H3 (H3Cit) and cell-free DNA (cfDNA), which serve as surrogate markers of NET formation, 79 patients with peripheral artery disease (PAD) following infrainguinal angioplasty stent implantation. Analysis cfDNA H3Cit was performed using Quant-iT™ PicoGreen® dsDNA Assay Kit or an ELISA, respectively. Within two years follow-up, the primary endpoint defined...
Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. Proinflammatory polarization is associated with increased degradation and propagation of inflammation whereas alternative within a Th2 cytokine wound healing angiogenesis. To understand if macrophages lead procoagulant macrophage subset we human monocyte derived proinflammatory an activation state. Alternative interleukin-4 IL-13 led phenotype characterized factor (TF) production...
Summary Interleukin (IL)-33, a member of the IL-1 family cytokines, is involved in various inflammatory conditions targeting amongst other cells endothelium. Besides regulating maturation and functions myeloid cells, granulocyte macrophage-colony stimulating factor (GM-CSF) macrophage-CSF (M-CSF) have been shown to play role such pathologies too. It was aim our study investigate possible influence IL-33 on GM-CSF M–CSF production by human endothelial cells. IL-33, but not IL-18 or IL-37,...
Perioperative oxygen (O2) therapy can cause hyperoxia. Extreme hyperoxia injure the cardiovascular system and remote organs.Our primary objective was to test hypothesis that exposure moderate will induce injury human umbilical vein endothelial cells (HUVECs), a model for studying vascular endothelium under controlled conditions.In-vitro cell culture study.Department of Anaesthesia, General Intensive Care Pain Management, Medical University Vienna, Austria. Study period from beginning October...
Inflammation is a key process during atherosclerotic lesion development and propagation. Recent evidence showed clearly that especially the inhibition of interleukin (IL)-1β reduced adverse events in human patients. Fatty acid oxidation (FAO) was previously demonstrated to interact with NOD-, LRR- pyrin domain-containing protein 3 (NLRP3) pathway which required for mature IL-1β secretion. To understand possible anti-inflammatory properties FAO inhibition, we tested effect pharmacological...