A5070424068- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Blood transfusion and management
- Venous Thromboembolism Diagnosis and Management
- Hemostasis and retained surgical items
- Abdominal Trauma and Injuries
- Cardiac Arrest and Resuscitation
- Blood properties and coagulation
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Blood donation and transfusion practices
- Cardiac, Anesthesia and Surgical Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Muscle and Compartmental Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Airway Management and Intubation Techniques
- Mechanical Circulatory Support Devices
- Extracellular vesicles in disease
- Platelet Disorders and Treatments
- Acute Myocardial Infarction Research
- Anesthesia and Pain Management
- Hemodynamic Monitoring and Therapy
- Hemophilia Treatment and Research
- Trauma Management and Diagnosis
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2016-2025
Paracelsus Medical University
2016-2025
Ludwig Boltzmann Institute for Digital Health and Prevention
2010-2025
Unfallkrankenhaus Salzburg
2014-2023
Allgemeine Unfallversicherungsanstalt
2013-2023
Novem (Netherlands)
2019-2021
University of Pennsylvania
2021
Committee on Publication Ethics
2021
Private University College of Education of the Diocese of Linz
2021
CSL (Switzerland)
2014-2020
The appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates.This retrospective analysis included patients who received >or= 5 units red blood cell concentrate within 24 hours. Coagulation was guided by thromboelastometry (ROTEM). Fibrinogen given as first-line haemostatic therapy when maximum clot firmness (MCF) measured FibTEM (fibrin-based test) <10 mm. Prothrombin complex (PCC) in...
Background: The aim of this study was to diagnose hyperfibrinolysis (HF) and its pattern using thrombelastometry correlate the diagnosis with mortality. Furthermore, routine laboratory based rotational analyzer (ROTEM)-derived variables were also correlated survival. Methods: Severe trauma patients showing HF in ROTEM consecutively enrolled study. Three different patterns compared: fulminant breakdown within 30 minutes, intermediate 60 late after minutes. Injury severity score (ISS),...
Abstract Introduction Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or platelet concentrate, compared fresh frozen plasma (FFP)-based therapy. Methods This retrospective analysis from Salzburg Trauma Centre (Salzburg, Austria) treated and/or PCC, but no FFP (fibrinogen-PCC group, n = 80), TraumaRegister DGU receiving ≥ 2 units FFP, concentrate/PCC...
Prediction of massive transfusion (MT) among trauma patients is difficult in the early phase management. Whole-blood thromboelastometry (ROTEM®) tests provide immediate information about coagulation status acute bleeding patients. We investigated their value for prediction MT.This retrospective study included admitted to AUVA Trauma Centre, Salzburg, Austria, with an injury severity score ≥16, from whom blood samples were taken immediately upon admission emergency room (ER). ROTEM® analyses...
Hyperfibrinolysis (HF) has been reported to occur in a range of 2% 34% trauma patients. Using rapid thromboelastography (r-TEG), we hypothesized that HF is (1) rarely present at admission on patients with severe injury and (2) associated crystalloid hemodilution. To further strengthen this hypothesis, created an vitro hemodilution model improve our mechanistic understanding the early HF.The registry was queried for who were highest-level activations admitted directly from scene (October...
Septic coagulopathy represents a very dynamic disease entity, tilting from initial hypercoagulability towards subsequent hypocoagulable state, entitled overt disseminated intravascular coagulation. Acute fibrinolysis shutdown has recently been described to be crucial component of in critically ill patients, although the underlying pathomechanisms, specific temporal kinetics and its outcome relevance patients with sepsis remain determined.In total, 90 (30 septic shock, 30 surgical controls...
Platelets play a central role in coagulation. Currently, information on platelet function following trauma is limited. We performed retrospective analysis of patients admitted to the emergency room (ER) at AUVA Trauma Centre, Salzburg, after sustaining traumatic injury. Immediately admission ER, blood was drawn for cell counts, standard coagulation tests, and testing. Platelet assessed by multiplate electrode aggregometry (MEA) using adenosine diphosphate (ADPtest), collagen (COLtest)...
BACKGROUND: Massive bleeding and transfusion of packed red blood cells (PRBC), fresh frozen plasma (FFP) platelets are associated with increased morbidity, mortality costs. PATIENTS AND METHODS: We analysed the requirements after implementation point-of-care (POC) coagulation management algorithms based on early, calculated, goal-directed therapy fibrinogen concentrate prothrombin complex (PCC) in different perioperative settings (trauma surgery, visceral transplant surgery (VTS),...
Goal-directed coagulation therapy is essential in the management of trauma patients with severe bleeding. Due to complex nature disorders trauma, a quick and reliable diagnostic tool essential. We report severely injured multiple patient who received haemostatic factor concentrates, guided by rotational thromboelastometry (ROTEM). Initial consisted fibrinogen concentrate (Haemocomplettan P), as maximum clot firmness ROTEM analyses was low, whereas clotting time normal. Later on, prothrombin...
Severe traumatic brain injury (sTBI) is often accompanied by coagulopathy and an increased risk of bleeding. To identify successfully treat bleeding disorders associated with sTBI, rapid assessment coagulation status crucial. This retrospective study was designed to assess the potential role whole-blood thromboelastometry (ROTEM(®), Tem International, Munich, Germany) in patients isolated sTBI (abbreviated scale [AIS](head) ≥3 AIS(extracranial) <3). Blood samples were obtained immediately...
We aimed to create a theoretical tool model the effect of three haemostatic agents containing fibrinogen (therapeutic plasma, cryoprecipitate, and concentrate) on patient's plasma level.A mathematical was developed step-wise. The relationship between amount agent level plotted for each agent. A concentration simulator (FCS(amount)) developed, where calculated from patient characteristics, target level. Refinements were introduced so that (i) FCS(amount) would account in vivo recovery, (ii)...
Fibrin-based clot firmness is measured as maximum amplitude (MA) in the functional fibrinogen (FF) thrombelastographic assay and (MCF) FIBTEM thromboelastometric assay. Differences between assays/devices may be clinically significant. Our objective was to compare parameters through standard (FF on a thrombelastography device [TEG®]; thromboelastometry [ROTEM®]) crossover ROTEM®; TEG®) analyses.Whole-blood samples from healthy volunteers were subjected analyses. Samples investigated native...
Purified prothrombin complex concentrate (PCC) is increasingly used as hemostatic therapy for trauma-induced coagulopathy (TIC). However, the impact of PCC administration on coagulation status among patients with TIC has not been adequately investigated. In this observational, descriptive study, data relating to thrombin generation were obtained from plasma samples gathered prospectively trauma upon emergency room (ER) admission and over following 7 days. Standard tests, including...