A5082055441- Synthesis and Properties of Aromatic Compounds
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Gene expression and cancer classification
- Blood transfusion and management
- Cell death mechanisms and regulation
- Asymmetric Synthesis and Catalysis
- Polydiacetylene-based materials and applications
- Ubiquitin and proteasome pathways
- Fullerene Chemistry and Applications
- Dialysis and Renal Disease Management
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Molecular Junctions and Nanostructures
- Renal function and acid-base balance
- Cancer Genomics and Diagnostics
- Graphene research and applications
- NF-κB Signaling Pathways
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Electrolyte and hormonal disorders
Oregon Health & Science University
2010-2025
University of Göttingen
2025
Uniformed Services University of the Health Sciences
2025
Medical University of Vienna
2012-2024
München Klinik
2024
Comprehensive Cancer Center Vienna
2013-2023
University of Toronto
1994-2022
St. Michael's Hospital
1996-2022
University of Applied Sciences Worms
2019
International Trauma Anesthesia and Critical Care Society
2016
The c-jun proto-oncogene encodes a component of the mitogen-inducible immediate-early transcription factor AP-1 and has been implicated as positive regulator cell proliferation G1-to-S-phase progression. Here we report that fibroblasts derived from c-jun-/- mouse fetuses exhibit severe defect undergo prolonged crisis before spontaneous immortalization. cyclin D1- E-dependent kinases (CDKs) E2F are poorly activated, resulting in inefficient Furthermore, absence c-Jun results elevated...
Abstract With the objective of discovering novel putative intervention sites for anticancer therapy, we compared transcriptional profiles breast cancer, lung squamous cell cancer (LSCC), adenocarcinoma (LAC), and renal (RCC). Each these tumor types still needs improvement in medical treatment. Our intention was to search genes not only highly expressed majority patient samples but which also exhibit very low or even absence expression a comprehensive panel 16 critical (vital) normal tissues....
Pain education, especially for undergraduates, has been identified as important to changing problematic pain practices, yet, no published data were found describing an integrated, interprofessional curriculum undergraduate students. Therefore, this project aimed develop, implement, and evaluate integrated curriculum, based on the International Association Study of curricula [http://www.iasp-pain.org/curropen.html], 540 students from six Health Science Faculties/Departments. Over 18-month...
In individuals with mammary carcinoma, the most relevant prognostic predictor of distant organ metastasis and clinical outcome is status axillary lymph node metastasis. Metastases form initially in sentinel nodes progress via connecting lymphatic vessels into postsentinel nodes. However, mechanisms consecutive colonization are unknown. Through analysis human carcinomas their matching nodes, we show here that intrametastatic bulk tumor cell invasion these highly correlate formation an vitro...
We aimed to create a theoretical tool model the effect of three haemostatic agents containing fibrinogen (therapeutic plasma, cryoprecipitate, and concentrate) on patient's plasma level.A mathematical was developed step-wise. The relationship between amount agent level plotted for each agent. A concentration simulator (FCS(amount)) developed, where calculated from patient characteristics, target level. Refinements were introduced so that (i) FCS(amount) would account in vivo recovery, (ii)...
Importance While national guidelines recommend avoidance of hypoxia, hypotension, and hypocarbia in the prehospital care traumatic brain injury (TBI), limited data validate association these adverse physiologic events with TBI outcomes. Objective To associations outcomes a US trauma network. Design, Setting, Participants This cohort study examined from 8 level I centers their affiliated ground air emergency medical services (EMS) agencies Linking Investigations Trauma Emergency Services...
Mouse 3T3 fibroblasts derived from fetuses lacking c-Jun were used to define an essential role of c-Jun, a main component the transcription factor AP-1, in cellular response alkylating agent methyl methanesulfonate (MMS). MMS represents most potent and selective activator stress-induced kinases JNK/SAPK p38, resulting very efficient induction hyperphosphorylation c-jun transcription. This induced apoptosis with high efficiency wild-type cells but not c-jun−/− cells. Resistance was...
ABSTRACT Fra1 is an immediate-early gene encoding a member of the AP-1 transcription factor family, which has diverse roles in development and oncogenesis. To determine function mouse development, was inactivated by targeting. Foetuses lacking were severely growth retarded died between E10.0 E10.5, owing to defects extra-embryonic tissues. The placental labyrinth layer, where X-gal staining revealed expression Fra1, reduced size largely avascular, marked decrease number vascular endothelial...
Born J, Ditschuneit I, Schreiber M, Dodt C, Fehm HL. Effects of age and gender on pituitary-adrenocortical responsiveness in humans. Eur J Endocrinol 1995;132:705–11. ISSN 0804–4643 This study compared plasma concentrations adrenocorticotropin (ACTH) cortisol young men (N = 10, mean 24.4 years), women 25.4 old 8, 81.6 years) 8. 83.5 under basal resting conditions after stimulation with either human corticotropin-releasing hormone (hCRH, 100 μg iv) or a combined injection hCRH (100 arginine...
Abstract In the present study, we used 2‐D differential gel electrophoresis (2‐D DIGE) and MS to screen biomarker candidates in serum samples obtained from 39 patients with breast cancer 35 controls. First, pooled matched age menopausal status. Then, depleted two most abundant proteins albumin IgG by immunoaffinity chromatography under partly denaturing conditions order enrich low‐abundance low molecular weight. Concentrated desalted were labeled three different CyDyes including one internal...
We show that elevated levels of Ret receptor are found in different sub-types human breast cancers and high correlates with decreased metastasis-free survival. The role ER+ cancer models was explored combining vitro vivo approaches. Our analyses revealed ligand-induced activation: (i) stimulates migration cells; (ii) rescues cells from anti-proliferative effects endocrine treatment (iii) expression cytokines the presence agents. Indeed, we uncovered a positive feed-forward loop between...
Accurate testing of HER2 is centrally important for breast cancer therapy and prognosis. Immunohistochemistry (IHC) fluorescence in situ hybridization (FISH) are current standard methods. As a potential alternative assessment HER2, we explored quantitative real-time reverse transcription-PCR (RT-PCR), fast inexpensive method yielding results insensitive to interobserver variability amenable standardized scoring.We assessed status at the DNA, mRNA, protein levels with FISH, RT-PCR, IHC 136...
Plakophilin 3 (PKP3) belongs to the p120ctn family of armadillo‐related proteins predominantly functioning in desmosome formation. Here we report that PKP3 is transcriptionally repressed by E‐cadherin repressor ZEB1 metastatic cancer cells. physically associates with two conserved E‐box elements promoter and partially represses activity corresponding human mouse fragments reporter gene assays. In tumours upregulated invasive cells at tumour–host interface, which accompanied downregulation...