A5042838758- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Acute Lymphoblastic Leukemia research
- Ovarian cancer diagnosis and treatment
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Digestive system and related health
- PARP inhibition in cancer therapy
- Hippo pathway signaling and YAP/TAZ
- Protein Degradation and Inhibitors
- Pluripotent Stem Cells Research
- Fibroblast Growth Factor Research
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
Ghent University
2015-2024
Cancer Research Institute Ghent
2016-2024
VIB-UGent Center for Inflammation Research
2014-2023
Institute of Molecular Biology and Biophysics
2022
Ghent University Hospital
2008-2021
Vlaams Instituut voor Biotechnologie
1999-2019
University of Toronto
2009
Laboratoire de Biologie du Développement
2005
VIB-VUB Center for Structural Biology
2001
University of Groningen
1997
Successful immunogenic apoptosis in experimental cancer therapy depends on the induction of strong host anti-tumor responses. Given that tumors are often resistant to apoptosis, it is important identify alternative molecular mechanisms elicit cell death. We have developed a genetic model which direct dimerization FADD combined with inducible expression RIPK3 promotes necroptosis. report necroptotic cells release damage-associated patterns and promote maturation dendritic cells, cross-priming...
Abstract Identification and validation of extracellular vesicle (EV)-associated biomarkers requires robust isolation characterization protocols. We assessed the impact some commonly implemented pre-analytical, analytical post-analytical variables in EV research. Centrifugal filters with different membrane types pore sizes are used to reduce large volume biofluids prior or concentrate EVs. compared five reported for their efficiency when using plasma, urine EV-spiked PBS. Regenerated...
Highlights•ZEB2 is highly expressed across the macrophage lineage•ZEB2 preserves tissue-specific identities of macrophages tissues•ZEB2 deficient are outcompeted by WT counterparts•LXRα crucial for Kupffer cell identity and maintained ZEB2SummaryHeterogeneity between different populations has become a defining feature this lineage. However, conserved factors remain largely unknown. The transcription factor ZEB2 best described its role in epithelial to mesenchymal transition; however, within...