A5048087410- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Signaling Pathways in Disease
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Acute Myeloid Leukemia Research
- Prostate Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Radiomics and Machine Learning in Medical Imaging
- CAR-T cell therapy research
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Head and Neck Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- X-ray Spectroscopy and Fluorescence Analysis
Medical University of Vienna
2016-2025
Christian Doppler Laboratory for Thermoelectricity
2019-2025
Center For Biomarker Research In Medicine
2018-2025
University of Veterinary Medicine Vienna
2016-2025
Comprehensive Cancer Center Vienna
2014-2025
Umeå University
2024-2025
Vienna General Hospital
2023-2024
Ludwig Boltzmann Institute for Cancer Research
2014-2024
Research Institute of Molecular Pathology
2003-2024
University of Vienna
1999-2024
3D cancer models are used as preclinical systems to mimic physiologic drug response. We provide evidence for robust changes of proliferation and metabolic capacity in by systematically analyzing spheroids colon cell lines. Spheroids showed relative lower AKT/mTOR/S6K activities compared cells cultured 2D. identified spatial alterations signaling, the level phospho-rpS6 decreased from spheroid surface center, closely recapitulating tumor areas around vessels vivo. These 3D-models displayed...
The epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitor erlotinib has been proven to be highly effective in the treatment of nonsmall cell lung cancer (NSCLC) harboring oncogenic EGFR mutations. majority patients, however, will eventually develop resistance and succumb disease. Recent studies have identified secondary mutations (EGFR T790M) amplification N-Methyl-N′-nitro-N-nitroso-guanidine (MNNG) HOS transforming gene (MET) oncogene as two principal mechanisms acquired...
Determining the interconverting conformations of dynamic proteins in atomic detail is a major challenge for structural biology. Conformational heterogeneity active site enzyme cyclophilin A (CypA) has been previously linked to its catalytic function, but extent which different these residues are correlated unclear. Here we compare conformational ensembles CypA by multitemperature synchrotron crystallography and fixed-target X-ray free-electron laser (XFEL) crystallography. The...
Abstract Personalized medicine aims to match the right drug with patient by using specific features of individual patient's tumor. However, current strategies personalized therapy matching provide treatment opportunities for less than 10% patients cancer. A promising method may be profiling biopsy specimens single-cell resolution directly quantify effects. We prospectively tested an image-based functional precision (scFPM) approach guide treatments in 143 advanced aggressive hematologic...
Humans are continuously exposed to polymeric materials such as in textiles, car tires and packaging. Unfortunately, their break down products pollute our environment, leading widespread contamination with micro- nanoplastics (MNPs). The blood–brain barrier (BBB) is an important biological that protects the brain from harmful substances. In study we performed short term uptake studies mice orally administered polystyrene micro-/nanoparticles (9.55 µm, 1.14 0.293 µm). We show nanometer sized...
Amidst the global plastic pollution crisis, gastrointestinal tract serves as primary entry point for daily exposure to micro- and nanoplastics. We investigated complex dynamics between polystyrene nanoplastics (PS-MNPs) four distinct human colorectal cancer cell lines (HT29, HCT116, SW480, SW620). Our findings revealed a significant size- concentration dependent uptake of 0.25, 1, 10 μm PS-MNPs across all lines, with HCT116 cells exhibiting highest rates. During division, particles were...
Because JunB is an essential gene for placentation, it was conditionally deleted in the embryo proper. JunBΔ/Δ mice are born viable, but develop severe low turnover osteopenia caused by apparent cell-autonomous osteoblast and osteoclast defects before a chronic myeloid leukemia-like disease. Although reported to be negative regulator of cell proliferation, junBΔ/Δ precursors osteoblasts show reduced proliferation along with differentiation defect vivo vitro. Mutant express elevated p16INK4a...