Dominik Wolf
A5032138074- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Functional Brain Connectivity Studies
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Dementia and Cognitive Impairment Research
- Single-cell and spatial transcriptomics
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Advanced Neuroimaging Techniques and Applications
- COVID-19 Clinical Research Studies
- Kruppel-like factors research
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Acute Lymphoblastic Leukemia research
Innsbruck Medical University
2016-2025
Tyrolean Cancer Research Institute
2015-2025
University Hospital Bonn
2015-2024
Universität Innsbruck
2015-2024
University Hospital Innsbruck
2004-2024
University of Bonn
2011-2024
Johannes Gutenberg University Mainz
2015-2024
University Medical Center of the Johannes Gutenberg University Mainz
2015-2024
Austrian Breast & Colorectal Cancer Study Group
2008-2023
University Hospital Dubrava
2023
Abstract Purpose: The forkhead box transcription factor FoxP3 is specifically expressed in T cells with regulatory properties (Treg). Recently, high numbers of Treg were described to be associated poor survival different malignancies. aim the presented study was determine prognostic effect mRNA expression (reflecting tissue content Treg) ovarian carcinoma and its relation cytokines, such as IFN-γ. Experimental Design: Total RNA isolated from 99 14 healthy biopsies. Real-time PCR for done...
PURPOSE Despite undergoing allogeneic hematopoietic stem cell transplantation (HCT), patients with acute myeloid leukemia (AML) internal tandem duplication mutation in the FMS-like tyrosine kinase 3 gene ( FLT3-ITD) have a poor prognosis, frequently relapse, and die as result of AML. It is currently unknown whether maintenance therapy using FLT3 inhibitors, such multitargeted inhibitor sorafenib, improves outcome after HCT. PATIENTS AND METHODS In randomized, placebo-controlled, double-blind...
To assess the potential role of FoxP3-expressing regulatory T cells (Tregs) in reversing obesity-linked insulin resistance and diabetic nephropathy rodent models humans.To characterize Tregs resistance, human visceral adipose tissue was first evaluated for Treg infiltration second, db/db mouse model evaluated.Obese patients with displayed significantly decreased natural but an increase adaptive their as compared lean control subjects. further evaluate pathogenic used. depletion using...
Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with diverse immune infiltration patterns, which has been linked to therapy sensitivity and resistance. However, full understanding of how phenotypes vary across different patient subgroups lacking. Here, we dissect the NSCLC tumor microenvironment at high resolution integrating 1,283,972 single cells from 556 samples 318 patients 29 datasets, including our dataset capturing low mRNA content. We stratify into...
Abstract Personalized medicine aims to match the right drug with patient by using specific features of individual patient's tumor. However, current strategies personalized therapy matching provide treatment opportunities for less than 10% patients cancer. A promising method may be profiling biopsy specimens single-cell resolution directly quantify effects. We prospectively tested an image-based functional precision (scFPM) approach guide treatments in 143 advanced aggressive hematologic...
Abstract Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression dissemination. Insight in cell-to-cell communication networks provides new therapeutic avenues to mold processes that contribute PCa tumor microenvironment (TME) alterations. Here we performed a detailed characterization of endothelial (TEC) delineate intercellular crosstalk TEC the TME. Methods isolated from 67 fresh radical prostatectomy (RP) specimens underwent multi-omic ex vivo...
Normothermic machine perfusion (NMP) has emerged as an innovative organ preservation technique. Developing understanding for the donor immune cell composition and its dynamic changes during NMP is essential. We aimed a comprehensive characterization of (sub)populations, trafficking cytokine release liver NMP. Single-cell transcriptome profiling human livers prior to, after transplantation shows abundance CXC chemokine receptor 1+/2+ (CXCR1+/CXCR2+) neutrophils, which significantly decreased...
Abstract Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of hippocampus on MR. The aim this study is to concurrent validity HarP toward local protocols, and its major sources variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T 3T following qualified based through standard web‐platform resegmented HarP. five most accurate followed segment 15 ADNI acquired three...
CD4+CD25+ regulatory T cells (Treg) are of critical importance for the maintenance tolerance. The kidney is frequently involved in autoimmune diseases, such as lupus erythematosus or glomerulonephritis (GN). Therefore, therapeutic efficacy Treg a cell-dependent murine model experimental anti-glomerular basement membrane (anti-GBM) GN was tested. Transfer 1 x 10(6) (day -1) into mice that were previously immunized with rabbit IgG -3) and subsequently received an injection anti-GBM serum 0)...
To expand the current knowledge about azacitidine (Aza) and donor lymphocyte infusions (DLI) as salvage therapy for relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) to identify predictors response survival, we retrospectively analyzed data of 154 patients with acute myeloid leukemia (AML, n = 124), myelodysplastic (MDS, 28), or myeloproliferative syndrome (n 2). All received a median number 4 courses Aza (range, 14) DLI were administered 105 (68%; DLI, 2; range, 1...
Both mast cells (MCs) and regulatory T (Tregs) have gained attention as immunosuppressive cell populations. To investigate a possible interaction, we used the Th1- Th17-dependent model of nephrotoxic serum nephritis (NTS), in which both MCs Tregs been shown to play protective role. Transfer wild-type (wt) into wt recipients almost completely prevents development NTS leads profound increase renal draining lymph nodes (LNs). By contrast, transfer animals deficient MCs, are characterized by an...
Ruxolitinib is a small-molecule inhibitor of the JAK kinases, which has been approved for treatment myelofibrosis, rare myeloproliferative neoplasm (MPN), but clinical trials are also being conducted in inflammatory-driven solid tumors. Increased infection rates have reported ruxolitinib-treated patients, and natural killer (NK) cells immune effector known to eliminate both virus-infected malignant cells. On this basis, we sought compare effects inhibition on human NK cohort 28 MPN patients...