A5014597444- Pain Mechanisms and Treatments
- Bone Metabolism and Diseases
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Diet and metabolism studies
- Neurobiology and Insect Physiology Research
- Bone health and treatments
- Neuropeptides and Animal Physiology
- Parkinson's Disease Mechanisms and Treatments
- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Invertebrate Immune Response Mechanisms
- CAR-T cell therapy research
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Signaling Pathways in Disease
- Pharmacological Effects of Natural Compounds
- Plant Toxicity and Pharmacological Properties
- TGF-β signaling in diseases
- Synthesis of Tetrazole Derivatives
- Pain Management and Opioid Use
- T-cell and B-cell Immunology
AstraZeneca (United States)
2025
Medical University of Vienna
2024
Austrian Academy of Sciences
2014-2024
Institute of Molecular Biotechnology
2014-2024
Boston Children's Hospital
2013-2023
Harvard University
2015-2023
Vienna Biocenter
2017-2020
Boston University
2013
Scripps Research Institute
2012
Massey University
2007
Innate Immunity in the Fly Gut Drosophila melanogaster is an important model system to study innate immunity, being both easy manipulate and lacking adaptive immune system. In order identify genes that regulate Cronin et al. (p. 340 ; published online 11 June) performed RNA interference screen on flies infected with oral bacterial pathogen, Serratia marcescens . Genes involved intestinal immunity regulation of hemocytes, macrophage-like cells critical for phagocytosis killing bacteria, were...
Abstract Type 2 diabetes mellitus is one of the most prevalent metabolic diseases presenting with systemic pathologies, including reproductive disorders in male diabetic patients. However, molecular mechanisms that contributing to spermatogenesis dysfunction patients have not yet been fully elucidated. Here, we perform STRT-seq examine transcriptome patients’ testes at single-cell resolution all major cell types testis. Intriguingly, whereas appears largely preserved, gene expression...
Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme de novo BH4 synthetic pathway, human single-nucleotide polymorphism studies, together with mouse genetic modeling, have demonstrated that decreased GCH1 leads both reduced pain. However, little known about regulation of Gch1 expression upon nerve injury whether this could be modulated as an analgesic...
Postoperative pain affects most patients after major surgery and can transition to chronic pain. The considerable side effects limited efficacy of current treatments underline the need for new therapeutic options. We observed increased amounts metabolites BH4 serotonin skin injury. Mast cells were primary postoperative sources Gch1 , rate-limiting enzyme in synthesis, itself an obligate cofactor production by tryptophan hydroxylase (Tph1). Mice deficient mast or cell–specific Tph1 showed...
Abstract Apoptosis inducing factor (AIF) has been shown to be a major contributor neuron loss in the immature brain after hypoxia-ischemia (HI). Indeed, mice bearing hypomorphic mutation causing reduced AIF expression are protected against neonatal HI. To further investigate possible molecular mechanisms of this neuroprotection, we generated an knock-in mouse by introduction latent transgene coding for flagged protein into Rosa26 locus, followed its conditional activation ubiquitously...
Abstract Elevated expression of folate receptor alpha (FRα) in various cancers, including epithelial ovarian cancer (EOC), highlights FRα as a potential target for the development novel therapeutics to treat FRα-expressing tumor types. AZD5335, an FRα-targeting antibody conjugated topoisomerase 1 inhibitor (TOP1i) payload, is currently being investigated FONTANA Phase I/IIa clinical trial (NCT#05797168), either single agent or combination with PARP1-selective (saruparib). Using EOC xenograft...
Lung cancer is the leading cause of deaths. Besides smoking, epidemiological studies have linked female sex hormones to lung in women; however, underlying mechanisms remain unclear. Here we report that receptor activator nuclear factor-kB (RANK), key regulator osteoclastogenesis, frequently expressed primary tumors, an active RANK pathway correlates with decreased survival, and pharmacologic inhibition reduces tumor growth patient-derived xenografts. Clonal genetic inactivation KRasG12D...
The HUSH (human silencing hub) complex contains the H3K9me3 binding protein M-phase phosphoprotein 8 (MPP8) and recruits histone methyltransferase SETDB1 as well Microrchidia CW-type zinc finger 2 (MORC2). Functional mechanistic studies of have hitherto been centered around while in vivo functions MPP8 MORC2 remain elusive. Here, we show that genetic inactivation Mphosph8 or Morc2a nervous system mice leads to increased brain size, altered architecture, behavioral changes. Mechanistically,...
The protein kinase MKK7 is linked to neuronal development and the onset of cancer. field, however, lacks high-quality functional probes that would allow for dissection its detailed functions. Against this background, we describe an effective covalent inhibitor based on pyrazolopyrimidine scaffold.