Belinda Angjeli

ORCID: 0009-0009-9224-2982
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About
Contact & Profiles
Research Areas
  • Neurobiology and Insect Physiology Research
  • Pain Mechanisms and Treatments
  • Hippo pathway signaling and YAP/TAZ
  • Invertebrate Immune Response Mechanisms
  • Ion Channels and Receptors
  • Cellular Mechanics and Interactions
  • Pain Management and Placebo Effect

Institute of Molecular Biotechnology
2018

Austrian Academy of Sciences
2010

Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, alone are insufficient for tumorigenesis, therefore it is paramount identify cooperating cancer-relevant signaling pathways. We devised an vivo near genome-wide, functional screen Drosophila and discovered multiple novel, evolutionarily-conserved pathways controlling Ras-driven epithelial tumorigenesis. Human gene orthologs fly hits were significantly downregulated thousands primary tumors, revealing...

10.1371/journal.pgen.1007688 article EN cc-by PLoS Genetics 2018-10-16
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