A5027622198- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Gene expression and cancer classification
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Neuroendocrine Tumor Research Advances
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- DNA Repair Mechanisms
- Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
Umeå University
2015-2024
Uppsala University Hospital
2008-2024
Uppsala University
2011-2021
Gävle Hospital
2013-2021
University Hospital of Umeå
2021
Skellefteå Hospital
2021
Shaanxi Normal University
2018
Institut de génétique et de biologie moléculaire et cellulaire
2012
Kawasaki Medical School
2012
University of Glasgow
2012
Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well predict prognosis and therapy response. So far, the value of these multigene signatures clinical practice is unclear, biologic importance individual genes difficult assess, published virtually do not overlap.Here, we describe a novel single institute cohort, including 196 non-small cancers (NSCLC) with information long-term follow-up. Gene array data were...
Tumor angiogenesis occurs through regulation of genes that orchestrate endothelial sprouting and vessel maturation, including deposition a vessel-associated extracellular matrix. CD93 is transmembrane receptor upregulated in tumor vessels many cancers, high-grade glioma. Here, we demonstrate regulates β1 integrin signaling organization fibronectin fibrillogenesis during vascularization. In cells mouse retina, was found to be expressed filopodia promote formation. The localization stabilized...
Abstract The complex interaction between cancer cells and the microenvironment plays an essential role in all stages of tumourigenesis. Despite significance this interplay, alterations protein composition underlying tumour–stroma interactions are largely unknown. aim study was to identify stromal proteins with clinical relevance non‐small cell lung (NSCLC). A list encompassing 203 candidate genes compiled based on gene expression array data available literature. these human NSCLC screened...
Vascular gene expression patterns in lower-grade gliomas (LGGs; diffuse World Health Organization [WHO] grades II-III gliomas) have not been thoroughly investigated. The aim of this study was to molecularly characterize LGG vessels and determine if tumor isocitrate dehydrogenase (IDH) mutation status affects vascular phenotype.Gene analyzed using an in-house dataset derived from microdissected total samples human glioma combination with data 289 available the database Cancer Genome Atlas....
Abstract Background The use of complementary and alternative medicine (CAM) by patients is widespread. However, there a lack knowledge regarding the extent details patient CAM in Sweden, especially rural Sweden. aim this study was to estimate characteristics among cancer Region Gävleborg. Methods A total 631 questionnaires were distributed which 376 responses registered, yielding response rate 59.6%. Questionnaires oncology at their first visit for curative treatment Department Oncology,...
In 2010, four subtypes (classical, proneural, mesenchymal, and neural) of glioblastoma multiforme (GBM) were defined by molecular genetic analyses. The objective this study was to assess whether gliomas, independently the type grade, could be subdivided into protein-based subtypes.A tissue microarray (TMA) approach applied incorporate samples low-grade high-grade gliomas five TMAs. High expression levels epidermal growth factor receptor (EGFR), CD44, c-MER proto-oncogene tyrosine kinase...
Background. The Swedish brain tumor registry has, since it was launched in 1999, provided significant amounts of data on histopathological diagnoses and important aspects surgical medical management these patients. purpose is mainly quality control, but also as a resource for research.Methods. Three healthcare regions, constituting 40% the population, have had an almost complete registration. following parameters are registered: diagnosis according to SNOMED/WHO classification, symptoms,...
Heat shock protein 90 (Hsp90) has been demonstrated to protect oncogenic variants of signalling molecules from degradation and may consequently serve as a therapeutic target for the treatment oesophageal cancer which adequate therapy is often lacking. We studied expression Hsp90 in tumour tissues human impact inhibition on cell lines using drug 17-allylamino-17-demethoxygeldanamycin (17-AAG). Quantitative immunohistochemistry was performed formalin-fixed paraffin-embedded patients with...
Recent studies suggest that the regulatory networks controlling functions of stem cells during development may be abnormally active in human cancers. An embryonic cell (ESC) gene signature was found to correlate with a more undifferentiated phenotype several cancer types including gliomas, and associated poor prognosis breast cancer. In present study, we used tissue microarrays 80 low-grade (WHO Grade II) 98 high-grade gliomas Grades III IV) investigate presence ESC-related proteins Nanog,...
Recently, glioma research has increased its focus on the diverse types of cells present in brain tumors. We observed previously that gliomas are associated with a profound accumulation mast (MCs) and here we investigate underlying mechanism. Gliomas express plethora chemoattractants. First, demonstrated pronounced migration human MCs toward conditioned medium from cultures cell lines. Subsequent cytokine array analyses media cells, cultured either serum‐containing or ‐free conditions,...
Background: Coexisting disease constitutes a challenge for the provision of optimal cancer care. The influence comorbidity on lung management and prognosis remains incompletely understood. We assessed treatment intensity in population-based setting patients with nonsmall cell cancer.Material methods: Our study was based information available Lung Cancer Data Base Sweden (LcBaSe), database generated by record linkage between National Register (NLCR) several other registers Sweden. NLCR...
Human cytomegalovirus (HCMV) has been indicated being a significant oncomodulator. Recent reports have suggested that an antiviral treatment alters the outcome of glioblastoma. We analysed performance commercial HCMV-antibodies applying immunohistochemical (IHC) methods on brain sample obtained from subject with verified HCMV infection, samples 14 control subjects, and tissue microarray block containing cores various tumours. Based these trials, we selected best performing antibody cohort...
Human papilloma virus (HPV) in patients with esophageal carcinoma has previously been studied an average detection rate of 15%, but the role HPV relation to survival is less clear. In cervical cancer, lung cancer and tonsil viral load a predictive factor for outcome treatment. The primary aim was study spectrum high-risk types tumors. Secondary, as pilot we investigated association between status rates. We compared both presence 16, 18, 31, 33, 39, 45, 52, 58, 67 clinical data from...
Background. Inhibition of the Insulin-like Growth Factor-1 receptor (IGF-1R) has resulted in extensive anti-tumor effects. Picropdophyllin (PPP, AXL1717) is a small-molecule inhibitor IGF-1R without inhibition closely related receptors including insulin and shown effects against wide range tumors animals. PPP currently tested as an orally administrated single agent treatment open-label combined Phase I/II clinical study advanced cancer patients with solid which progress spite several lines...
WNT5A has been identified as an important ligand in the malignant progression of a number tumours. Although signalling is often altered cancer, ligand's role either tumour suppressor or oncogene varies between types and contemporary issue for investigators β-catenin-independent WNT oncology. Here, we report that one initial effects active melanoma cells alteration cellular energy metabolism specifically increase aerobic glycolysis. This was found to be at least part due Akt lactate...
Lung cancer is the leading cause of deaths. Besides smoking, epidemiological studies have linked female sex hormones to lung in women; however, underlying mechanisms remain unclear. Here we report that receptor activator nuclear factor-kB (RANK), key regulator osteoclastogenesis, frequently expressed primary tumors, an active RANK pathway correlates with decreased survival, and pharmacologic inhibition reduces tumor growth patient-derived xenografts. Clonal genetic inactivation KRasG12D...
// Ananya Roy 1, 6, Sanaz Attarha 1 , Holger Weishaupt Per-Henrik Edqvist 2 Fredrik J. Swartling Michael Bergqvist 3 Florian A. Siebzehnrubl 4 Anja Smits 5, 7 Pontén Elena Tchougounova Uppsala University, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden Science for Life Umeå Radiation Sciences, Umeå, Cardiff University School Biosciences, European Cancer Stem Cell Research Institute, Cardiff, United Kingdom 5 Neuroscience, Neurology, 6 Swedish...
Background: The primary objective of this study was to compare the progression-free survival (PFS) at 12 weeks between patients treated with IGF-1R pathway modulator AXL1717 (AXL) and docetaxel (DCT).Material methods: conducted 19 centers in five countries. A total 99 previously treated, locally advanced or metastatic non-small cell lung cancer (NSCLC) squamous carcinoma (SCC) adenocarcinoma (AC) subtypes need additional treatment were randomized either 300 400 mg AXL as daily BID (58...
We have developed a method to isolate and analyze nascent human reticulocytes in peripheral blood for the presence of micronuclei (MN). For very short time show residual expression transferrin receptor. Using immunomagnetic separation cells expressing receptor, population immature (Trf-Ret) was isolated from blood. In humans, spleen actively removes micronucleated erythrocytes but during lifetime Trf-Ret only fraction (less than about 20%) MN-containing will been eliminated. Cells were...