A5044367456- Liver physiology and pathology
- Carcinogens and Genotoxicity Assessment
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- HER2/EGFR in Cancer Research
- Glutathione Transferases and Polymorphisms
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Effects and risks of endocrine disrupting chemicals
- 3D Printing in Biomedical Research
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Pluripotent Stem Cells Research
- Gene expression and cancer classification
- Bladder and Urothelial Cancer Treatments
- Computational Drug Discovery Methods
- Genomics, phytochemicals, and oxidative stress
- Organ Transplantation Techniques and Outcomes
- Animal testing and alternatives
- Air Quality and Health Impacts
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
Leibniz Research Centre for Working Environment and Human Factors
2016-2025
TU Dortmund University
2016-2025
University of Cologne
2014-2023
Universitat de València
2023
University of Konstanz
2023
Tongji University
2023
S:t Eriks Ögonsjukhus
2012-2021
Johannes Gutenberg University Mainz
2000-2017
South Valley University
2017
University Medical Center of the Johannes Gutenberg University Mainz
2010-2017
Abstract Estrogen receptor (ER) expression and proliferative activity are established prognostic factors in breast cancer. In a search for additional motifs, we analyzed the gene patterns of 200 tumors patients who were not treated by systemic therapy after surgery using discovery approach. After performing hierarchical cluster analysis, identified coregulated genes related to biological process proliferation, steroid hormone expression, as well B-cell T-cell infiltration. We calculated...
A profound cytotoxic action of the antimalarial, artesunate (ART), was identified against 55 cancer cell lines U.S. National Cancer Institute (NCI). The 50% inhibition concentrations (IC<sub>50</sub> values) for ART correlated significantly to doubling times (<i>P</i> = 0.00132) and portion cells in G<sub>0</sub>/G<sub>1</sub> 0.02244) or S cycle phases 0.03567). We selected mRNA expression data 465 genes obtained by microarray hybridization from NCI base. These belong different biological...
The hepatic integration of human adipose tissue derived mesenchymal stem cells (hAT-MSCs) in vivo with or without prior differentiation to hepatocyte-like vitro was investigated.Cells, isolated either from peritoneal subcutaneous tissue, expressed cell surface markers and featured multiple lineage differentiation. Under conditions favouring hepatocyte differentiation, hAT-MSCs gained hepatocytic functions including urea formation, glycogen synthesis, cytochrome P450 enzyme activity,...
Only little is known about how cells coordinately behave to establish functional tissue structure and restore microarchitecture during regeneration. Research in this field hampered by a lack of techniques that allow quantification architecture its development. To bridge gap, we have established procedure based on confocal laser scans, image processing, three-dimensional reconstruction, as well quantitative mathematical modeling. As proof principle, reconstructed modeled liver regeneration...
<b>Aims:</b> At present, clinical success of hepatocyte transplantation as an alternative to whole liver is hampered by the limited availability suitable donor organs for isolation transplantable hepatocytes. Hence, novel cell sources are required deliver hepatocytes adequate quality use. Mesenchymal stem cells (MSCs) from human bone marrow may have potential differentiate into in vitro and vivo. <b>Methods:</b> Isolated MSCs were selected density gradient centrifugation plastic adherence,...
Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well predict prognosis and therapy response. So far, the value of these multigene signatures clinical practice is unclear, biologic importance individual genes difficult assess, published virtually do not overlap.Here, we describe a novel single institute cohort, including 196 non-small cancers (NSCLC) with information long-term follow-up. Gene array data were...
Abstract Purpose: Although the central role of immune system for tumor prognosis is generally accepted, a single robust marker not yet available. Experimental Design: On basis receiver operating characteristic analyses, markers were identified from 60-gene B cell–derived metagene and analyzed in gene expression profiles 1,810 breast cancer; 1,056 non–small cell lung carcinoma (NSCLC); 513 colorectal; 426 ovarian cancer patients. Protein RNA levels examined paraffin-embedded tissue 330 The...
Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often manifest themselves in functional deficits that are not necessarily based on cell death, but rather minor changes relating to differentiation or communication. The fields DNT/RT would greatly benefit from vitro tests allow the identification toxicant-induced cellular proteostasis, its underlying transcriptome network. Therefore, 'human embryonic stem (hESC)-derived novel alternative test systems (ESNATS)'...
Several studies suggest a link between circadian rhythm disturbances and tumorigenesis. However, the association clock genes prognosis in breast cancer has not been systematically studied. Therefore, we examined expression of 17 components tumors from 766 node-negative patients that were untreated both neoadjuvant adjuvant settings. In addition, their with metastasis-free survival (MFS) correlation to clinicopathological parameters investigated. Aiming estimate functionality clockwork,...
It is currently not well known how necroptosis and responses manifest in vivo. Here, we uncovered a molecular switch facilitating reprogramming between two alternative modes of signaling hepatocytes, fundamentally affecting immune hepatocarcinogenesis. Concomitant necrosome NF-κB activation which physiologically express low concentrations receptor-interacting kinase 3 (RIPK3), did lead to immediate cell death but forced them into prolonged "sublethal" state with leaky membranes, functioning...
Co-exposure to cadmium, cobalt, lead and other heavy metals occurs in many occupational settings, such as pigment batteries production, galvanization recycling of electric tools. However, little is known about interactions between several metals. In the present study we determined DNA single strand break (DNA-SSB) induction repair capacity for 8-oxoguanine mononuclear blood cells 78 individuals co-exposed cadmium (range concentrations air: 0.05–138.00 μg/m 3 ), cobalt (range: 0–10 ) 0–125 )....