Achim Weber
A5061091984- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- Liver Diseases and Immunity
- Inflammatory Bowel Disease
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
- Hepatitis Viruses Studies and Epidemiology
- Genetic factors in colorectal cancer
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Neuroendocrine Tumor Research Advances
- Diverticular Disease and Complications
- Protein Tyrosine Phosphatases
- Colorectal Cancer Treatments and Studies
University Hospital of Zurich
2016-2025
University of Zurich
2016-2025
BG Klinik Tübingen
2020-2025
University of Tübingen
2004-2025
National Center for Tumor Diseases
2023
Heidelberg University
2023
University Hospital Heidelberg
2023
German Cancer Research Center
2023
Case Western Reserve University
2020
Swiss Integrative Center for Human Health
2013-2017
Abstract Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1–5 . Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification patients optimal response to therapy unmet need 6,7 Here we report the progressive accumulation exhausted, unconventionally activated CD8 + PD1 T cells in NASH-affected livers. In preclinical models NASH-induced therapeutic immunotherapy targeted at programmed...
<h3>Objective</h3> The nature of the tumour-infiltrating leucocytes (TILs) is known to impact clinical outcome in carcinomas, including hepatocellular carcinoma (HCC). However, role B cells (TIBs) remains controversial. Here, we investigate TIBs and their interaction with T on HCC patient prognosis. <h3>Design</h3> Tissue samples were obtained from 112 patients Singapore, Hong Kong Zurich analysed using immunohistochemistry immunofluorescence. RNA expression <i>CD19, CD8A, IFNG</i> was...
Background: Patients treated with bisphosphonates because of bone metastases have been shown to develop osteonecrosis the jaws. In present study, we examined histologic findings these cases. As similarities between this disorder and infected osteoradionecrosis (IORN) are described, both lesions were compared. Methods: We investigated eight patients bisphosphonate treatment (four female, four male; median age: 65.6 years; cancer: multiple myeloma in five patients, breast cancer three...
Hepatocellular carcinoma (HCC) is a heterogeneous disease with poor prognosis and limited methods for predicting patient survival. The nature of the immune cells that infiltrate tumours known to impact clinical outcome. However, molecular events regulate this infiltration require further understanding. Here ability genes expressed in tumour microenvironment predict progression was investigated.Using quantitative PCR, expression 14 resected tissues from 57 Singaporean patients analysed....
Morphologic intratumor heterogeneity is well known to exist in hepatocellular carcinoma (HCC), but very few systematic analyses of this phenomenon have been performed. The aim study was comprehensively characterize morphologic HCC. Also, taken into account were well-known immunohistochemical markers and molecular changes liver cells that are considered proposed classifications cell neoplasms or discussed as therapeutic targets.In HCC 23 patients without medical pretreatment, a total 120...
In many organs, including the intestine and skin, cancers originate from cells of stem or progenitor compartment. Despite its nomenclature, cellular origin hepatocellular carcinoma (HCC) remains elusive. contrast to most liver lacks a defined cell population for organ maintenance. Previous studies suggest that both hepatocytes facultative within biliary compartment are capable generating HCC. As HCCs with signature carry worse prognosis, understanding HCC is clinical relevance. Here, we used...
Abstract Control of intestinal epithelial stemness is crucial for tissue homeostasis. Disturbances in function are implicated inflammatory and neoplastic diseases the gastrointestinal tract. Here we report that mitochondrial plays a critical role maintaining Using cell (IEC)-specific mouse models, show loss HSP60, chaperone, activates unfolded protein response (MT-UPR) results dysfunction. HSP60-deficient crypts display proliferation, accompanied by release WNT10A RSPO1. Sporadic failure...
It is currently not well known how necroptosis and responses manifest in vivo. Here, we uncovered a molecular switch facilitating reprogramming between two alternative modes of signaling hepatocytes, fundamentally affecting immune hepatocarcinogenesis. Concomitant necrosome NF-κB activation which physiologically express low concentrations receptor-interacting kinase 3 (RIPK3), did lead to immediate cell death but forced them into prolonged "sublethal" state with leaky membranes, functioning...
The progression of non-alcoholic steatohepatitis (NASH) to fibrosis and hepatocellular carcinoma (HCC) is aggravated by auto-aggressive T cells. gut-liver axis contributes NASH, but the mechanisms involved consequences for NASH-induced liver cancer remain unknown. We investigated role gastrointestinal B cells in development HCC.