A5059254085- Cholangiocarcinoma and Gallbladder Cancer Studies
- Parasites and Host Interactions
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- IL-33, ST2, and ILC Pathways
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Vitamin D Research Studies
- Cytokine Signaling Pathways and Interactions
- Pediatric Hepatobiliary Diseases and Treatments
- Parasite Biology and Host Interactions
- Helicobacter pylori-related gastroenterology studies
- interferon and immune responses
- Reproductive tract infections research
- Cancer Mechanisms and Therapy
- Pregnancy and Medication Impact
- Immunotherapy and Immune Responses
- Gestational Diabetes Research and Management
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Research on Leishmaniasis Studies
- Nematode management and characterization studies
- Fibroblast Growth Factor Research
AiCuris (Germany)
2024
Columbia University
2021-2022
Technical University of Munich
2016-2022
Klinikum rechts der Isar
2022
Institute of Medical Microbiology and Hygiene
2016-2021
German Center for Infection Research
2019
Cancer-associated fibroblasts (CAF) may exert tumor-promoting and tumor-suppressive functions, but the mechanisms underlying these opposing effects remain elusive. Here, we sought to understand potentially functions by interrogating functional relationships among CAF subtypes, their mediators, desmoplasia, tumor growth in a wide range of types metastasizing liver, most common organ site for metastasis. Depletion hepatic stellate cells (HSC), which represented main source mice patients our...
Schistosomiasis is a nontransplacental helminth infection. Chronic infection during pregnancy suppresses allergic airway responses in offspring. We addressed the question whether utero exposure to chronic schistosome (Reg phase) mice affects B-cell and T-cell development. Therefore, we focused our analyses on differentiation capacity induced by epigenetic changes promoter regions of signature cytokines Here, show that naïve T cells from offspring infected female had strong differentiate into...
Introduction Schistosomiasis is a neglected tropical disease (NTD) caused by blood-dwelling flatworms which develop from skin-penetrating cercariae, the freely swimming water-borne infective stage of Schistosoma mansoni , into adult worms. This natural course infection can be mimicked in experimental mouse models schistosomiasis. However, only maximum 20-30% penetrated cercariae mature fecund adults. The reasons for this are unknown but could potentially involve soluble factors innate immune...
Helicobacter pylori chronically colonizes the stomach and is strongly associated with gastric cancer. Its concomitant occurrence helminths such as schistosomes has been linked to reduced cancer incidence, presumably due suppression of H. pylori-associated pro-inflammatory responses. However, experimental evidence in support a causal link or mutual interaction both pathogens lacking. We investigated effects co-infection during different immune phases S. mansoni infection. Surprisingly,...
Chronic hepatitis B develops more frequently in countries with high prevalence of helminth infections. The crosstalk between these 2 major liver-residing pathogens, Schistosoma mansoni and virus (HBV), is barely understood.We used state-of-the-art models for both acute chronic HBV infection to study the pathogen-crosstalk during different immune phases schistosome infection.Although liver pathology caused by was not affected either or infection, S influenced outcomes a phase-dependent...
Inactivated parapoxvirus ovis (iPPVO) exerts strong immunomodulatory effects on innate immune cells, making it an attractive therapeutic candidate. However, little is known about the signaling pathways that are involved in iPPVO-induced responses.