A5085709802- Immune cells in cancer
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- IL-33, ST2, and ILC Pathways
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Mast cells and histamine
- Respiratory viral infections research
- Complement system in diseases
- Reproductive System and Pregnancy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
University Hospital Regensburg
2016-2025
Umicore (Belgium)
2025
University of Regensburg
2014-2024
University of Dundee
2023
Medical University of Vienna
2023
Mannheim University of Applied Sciences
2022
Technical University of Munich
2022
German Cancer Research Center
2022
Heidelberg University
2022
ORCID
2021
Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing different chemokine receptor patterns: CCR2+CX3CR1+Ly-6Chi and CCR2–CX3CR1++Ly-6Clo monocytes. Both C-C motif (CCR2) C-X3-C 1 (CX3CR1) linked to progression of atherosclerotic plaques. Here, we analyzed mouse monocyte apoE-deficient mice traced their differentiation usage as they accumulated within Blood counts were elevated apoE–/– skewed toward an increased frequency CCR2+Ly-6Chi monocytes fed a...
Abstract Tumor-associated macrophages (TAM) form a major component of the tumor stroma. However, important concepts such as TAM heterogeneity and nature monocytic precursors remain speculative. Here, we show for first time that mouse mammary tumors contained functionally distinct subsets TAMs provide markers their identification. Furthermore, in search progenitors, tumor-monocyte pool almost exclusively consisted Ly6ChiCX3CR1low monocytes, which continuously seeded renewed all...
Monocyte recruitment to sites of inflammation is regulated by members the chemokine family chemotactic cytokines. However, mechanisms that govern migration monocytes from bone marrow blood and inflamed tissues are not well understood. Here we report CC receptor 2 (CCR2) highly expressed on a subpopulation whose numbers markedly decreased in CCR2(-/-) mice. In marrow, however, mice had an increased number monocytes, suggesting CCR2 critical for monocyte egress. Intravenous infusion ex...
Abstract Pathogenic human coronaviruses (CoVs), such as the severe acute respiratory syndrome (SARS)-CoV and Middle East syndrome–CoV, cause illness. Epidemiological data from 2002–2003 SARS epidemic recent outbreak indicate that there may be sex-dependent differences in disease outcomes. To investigate these differences, we infected male female mice of different age groups with SARS-CoV analyzed their susceptibility to infection. Our results showed were more susceptible infection compared...
Although macrophages (MPhi) are known as essential players in wound healing, their contribution to recovery from spinal cord injury (SCI) is a subject of debate. The difficulties distinguishing between different MPhi subpopulations at the lesion site have further contributed controversy and led common view functionally homogenous. Given massive accumulation injured activated resident microglia, which native immune occupants central nervous system (CNS), recruitment additional infiltrating...
Type 1 IFNs (IFN-I) generally protect mammalian hosts from virus infections, but in some cases, IFN-I is pathogenic. Because protective, it commonly used to treat infections for which no specific approved drug or vaccine available. The Middle East respiratory syndrome–coronavirus (MERS-CoV) such an infection, yet little known about the role of this setting. Here, we show that signaling protective during MERS-CoV infection. Blocking resulted delayed clearance, enhanced neutrophil...
Abstract Peritoneal macrophages are one of the most studied macrophage populations in body, yet composition, developmental origin and mechanisms governing maintenance this compartment controversial. Here we show resident F4/80 hi GATA6 + long-lived, undergo non-stochastic self-renewal retain cells embryonic for at least 4 months mice. However, Ly6C monocytes constitutively enter peritoneal cavity a CCR2-dependent manner, where they mature into short-lived lo MHCII that act, part, as...
Abstract The chemokine receptors CCR2 and CCR5 play important roles in the recruitment of monocytes/macrophages T cells. To better understand role both murine models inflammatory diseases to recognize potential problems when correlating these data humans, we have generated mAbs against CCR5. In mice is homogeneously expressed on monocytes 2–15% cells, closely resembling expression pattern humans. contrast NK cells are highly positive. addition, 3–10% CD4 10–40% CD8-positive weakly detectable...
The chemokine receptor CCR2 plays a vital role for the induction of autoimmunity in central nervous system. However, it remains unclear how pathogenic response is mediated by CCR2-bearing cells. By combining bone marrow chimerism with gene targeting we detected mild disease-modulating during experimental autoimmune encephalomyelitis, model system autoimmunity, on radio-resistant cells that was independent from targeted expression endothelia. Interestingly, absence lymphocytes did not...
CCR5, a chemokine receptor expressed on T cells and macrophages, is the principal coreceptor for M-tropic HIV-1 strains. Recently, we described an NH2-terminal modification of CCR5 ligand regulated activation, normal cell secreted (RANTES), aminooxypentane-RANTES (AOP-RANTES), that showed potent inhibition macrophage infection by under conditions where RANTES was barely effective. To investigate mechanism AOP-RANTES HIV infectivity examined surface expression using monoclonal anti-CCR5...
Abstract Radiotherapy induces and promotes innate adaptive immunity in which host STING plays an important role. However, radioresistance irradiated tumors can also develop, resulting relapse. Here we report a mechanism by extrinsic resistance develops after local ablative radiation that relies on the immunosuppressive action of STING. The STING/type I interferon pathway enhances suppressive inflammation recruiting myeloid cells part via CCR2 pathway. Germ-line knockouts or treatment with...
Mononuclear phagocytes have been attributed a crucial role in the host defense toward influenza virus (IV), but their contribution to influenza-induced lung failure is incompletely understood. We demonstrate for first time that lung-recruited "exudate" macrophages significantly contribute alveolar epithelial cell (AEC) apoptosis by release of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) murine model pneumonia. Using CC-chemokine receptor 2-deficient (CCR2(-/-)) mice...
MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits by constraining the nlrp3 inflammasome. was increased in biopsies from patients with active IBD and preclinical models of inflammation. miR-223-/y mice presented exacerbated myeloid-driven experimental colitis heightened clinical, histopathological,...