Adrianus C. M. Boon
A5021815882- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- interferon and immune responses
- T-cell and B-cell Immunology
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Immune Response and Inflammation
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infections and Outbreaks Research
- vaccines and immunoinformatics approaches
- Infection Control and Ventilation
- RNA and protein synthesis mechanisms
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Impact on Reproduction
Washington University in St. Louis
2016-2025
Bipar
2023-2025
Emory University
2024
St. Jude Children's Research Hospital
2006-2023
Universidade Federal de Minas Gerais
2022-2023
University of Illinois Urbana-Champaign
2023
Czech Academy of Sciences, Institute of Microbiology
2022
Columbia University
2021
Cornell University
2021
Weill Cornell Medicine
2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly introduced antibody and vaccine countermeasures. Here, using monoclonal antibodies (mAbs), animal immune sera, human convalescent sera from recipients of BNT162b2 mRNA vaccine, we report impact on neutralization a panel authentic including B.1.1.7 isolate, chimeric strains with South African or Brazilian spike genes isogenic...
The recent emergence of B.1.1.529, the Omicron variant
The microbiota is known to modulate the host response influenza infection through as-yet-unclear mechanisms. We hypothesized that components of exert effects type I interferon (IFN), a hypothesis supported by analysis in gain-of-function genetic mouse model. Here we show microbially associated metabolite, desaminotyrosine (DAT), protects from augmentation IFN signaling and diminution lung immunopathology. A specific human-associated gut microbe, Clostridium orbiscindens, produced DAT rescued...
Immune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions, principally in cells of myeloid lineage. Cell culture studies suggest regulates inflammation through its inhibitory effects on cytokine and reactive oxygen species production. To evaluate the functions Irg1 vivo, we challenged wild-type (WT) Irg1-/- mice with Mycobacterium tuberculosis (Mtb) monitored disease progression. Irg1-/-, but not WT, succumbed rapidly to Mtb, mortality...
We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and influenza patients. Compared to patients with influenza, COVID-19 exhibited largely equivalent lymphocyte counts, fewer monocytes, lower surface human leukocyte antigen (HLA)-class II expression on selected monocyte populations. Furthermore, decreased HLA-DR intermediate monocytes predicted severe disease. In contrast prevailing assumptions, very few (7 168) cytokine profiles indicative storm syndrome. After...
The development of an effective vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent disease 2019 (COVID-19), is a global priority. Here, we compare protective capacity intranasal and intramuscular delivery chimpanzee adenovirus-vectored encoding prefusion stabilized spike protein (chimpanzee adenovirus [ChAd]-SARS-CoV-2-S) in Golden Syrian hamsters. Although immunization with ChAd-SARS-CoV-2-S induces robust spike-protein-specific antibodies...
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated and postacute cognitive neuropsychiatric symptoms including impaired memory, concentration, attention, sleep affect. Mechanisms underlying these brain remain understudied. Here we report that SARS-CoV-2-infected hamsters exhibit a lack of viral neuroinvasion despite aberrant blood-brain barrier permeability. Hamsters patients deceased from disease 2019 (COVID-19) also microglial activation...
Abstract The CVnCoV (CureVac) mRNA vaccine for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was recently evaluated in a phase 2b/3 efficacy trial humans 1 . CV2CoV is second-generation containing non-modified nucleosides but with optimized non-coding regions and enhanced antigen expression. Here we report the results of head-to-head comparison immunogenicity protective non-human primates. We immunized 18 cynomolgus macaques two doses 12 μg lipid nanoparticle-formulated or...
The rapid spread of the SARS-CoV-2 Omicron (B.1.1.529) variant, including in highly vaccinated populations, has raised important questions about efficacy current vaccines. In this study, we show that mRNA-based BNT162b2 vaccine and adenovirus-vector-based Ad26.COV2.S provide robust protection against high-dose challenge with variant cynomolgus macaques. We 30 macaques homologous heterologous prime-boost regimens Ad26.COV2.S. Following challenge, demonstrated control virus bronchoalveolar...
Abstract A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against infection with Omicron subvariants 1,2 , although still severe disease. Enhanced mucosal immunity may be required to block and onward transmission. Intranasal administration has proven inconsistent 3–7 suggesting alternative immunization strategies required. Here we show intratracheal boosting a bivalent Ad26-based vaccine results in substantial induction humoral cellular near-complete BQ.1.1...
Abstract A nasally delivered chimpanzee adenoviral-vectored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (ChAd-SARS-CoV-2-S) is currently used in India (iNCOVACC). Here, we update this by creating ChAd-SARS-CoV-2-BA.5-S, which encodes a prefusion-stabilized BA.5 spike protein. Whereas serum neutralizing antibody responses induced monovalent or bivalent adenoviral vaccines were poor against the antigenically distant XBB.1.5 strain and insufficient to protect passive...
A pandemic H5N1 influenza outbreak would be facilitated by an absence of immunity to the avian-derived virus in human population. Although this condition is likely regard hemagglutinin-mediated immunity, neuraminidase (NA) viruses (avN1) and endemic H1N1 (huN1) are classified same serotype. We hypothesized that immune response huN1 could mediate cross-protection against infection.Mice were immunized NA a contemporary strain DNA vaccination. They challenged with recombinant A/Puerto Rico/8/34...
Objective To determine whether maternal influenza virus infection in the second and third trimesters of pregnancy results transplacental transmission infection, auto‐antibody production or an increase complications pregnancy. Design Case‐control cohort study. Population Study control cohorts were derived from 3975 women who consecutively delivered at two Nottingham teaching hospitals between May 1993 July 1994. A complete set three sera was available for 1659 women. Methods Paired ante‐...
Despite the prevalence of H5N1 influenza viruses in global avian populations, comparatively few cases have been diagnosed humans. Although viral factors almost certainly play a role limiting human infection and disease, host genetics most likely contribute substantially. To model context virus infection, we determined lethal dose highly pathogenic (A/Hong Kong/213/03) C57BL/6J DBA/2J mice identified genetic elements associated with survival after infection. The these hosts varied by 4 logs...
Abstract Despite the development and deployment of antibody vaccine countermeasures, rapidly-spreading SARS-CoV-2 variants with mutations at key antigenic sites in spike protein jeopardize their efficacy. The recent emergence B.1.1.529, Omicron variant1,2, which has more than 30 protein, raised concerns for escape from protection by vaccines therapeutic antibodies. A test potential countermeasures against B.1.1.529 is activity pre-clinical rodent models respiratory tract disease. Here, using...
Infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is associated onset of neurological and psychiatric symptoms during after acute phase illness