A5100366032- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Adipose Tissue and Metabolism
- Retinal Development and Disorders
- Genetic and phenotypic traits in livestock
- Cardiomyopathy and Myosin Studies
- Peroxisome Proliferator-Activated Receptors
- Genetic Associations and Epidemiology
- Glaucoma and retinal disorders
- Genetics, Aging, and Longevity in Model Organisms
- Gene expression and cancer classification
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- RNA modifications and cancer
- Hormonal Regulation and Hypertension
University of Tennessee Health Science Center
2016-2025
University of Michigan–Ann Arbor
2024-2025
Nantong University
2011-2024
Sichuan Agricultural University
2022-2024
Shanghai University of Traditional Chinese Medicine
2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Affiliated Hospital of Nantong University
2011-2024
Institut thématique Génétique, génomique et bioinformatique
2004-2024
Ducks Unlimited
2024
Xuan Wu Hospital of the Capital Medical University
2023
Recombinant inbred (RI) strains are an important resource for mapping complex traits in many species. While large RI panels available Arabidopsis, maize, C. elegans, and Drosophila, mouse typically consist of fewer than 30 lines. This is a severe constraint on the power precision efforts greatly hampers analysis epistatic interactions.In order to address these limitations provide community with more effective collaborative panel we generated new BXD from two independent advanced intercrosses...
The gastrointestinal tract harbors a complex and diverse microbiota that has an important role in host metabolism. Microbial diversity is influenced by combination of environmental genetic factors associated with several polygenic diseases. In this study we combined next-generation sequencing, mapping, set physiological traits the BXD mouse population to explore explain differences gut its impact on metabolic traits. Molecular profiling revealed quantitative microbial composition among...
Traditional Chinese medicine (TCM) has been used for centuries to treat various types of inflammation and tumors the digestive system. Portulaca oleracea L. (POL), in TCM thousands years. The chemical composition POL is variable includes flavonoids, alkaloids, terpenoids organic acids other classes natural compounds. Many these compounds exhibit powerful anti-inflammatory anti-cancer-transforming effects In this review, we focus on potential therapeutic role NASH, gastritis colitis their...
Adult hippocampal neurogenesis is highly variable and heritable among laboratory strains of mice. also remarkably plastic can be modulated by environment activity. Here, we provide a systematic quantitative analysis adult in two large genetic reference panels recombinant inbred (BXD AXB/BXA, n = 52 strains). We combined data on variation with new transcriptome database to extract set 190 genes expression patterns that are covary rates ( i ) cell proliferation, ii survival, or the numbers...
Despite the prevalence of H5N1 influenza viruses in global avian populations, comparatively few cases have been diagnosed humans. Although viral factors almost certainly play a role limiting human infection and disease, host genetics most likely contribute substantially. To model context virus infection, we determined lethal dose highly pathogenic (A/Hong Kong/213/03) C57BL/6J DBA/2J mice identified genetic elements associated with survival after infection. The these hosts varied by 4 logs...
Phenome-wide association is a novel reverse genetic strategy to analyze genome-to-phenome relations in human clinical cohorts. Here we test this approach using large murine population segregating for ∼5 million sequence variants, and compare our results those extracted from matched analysis of gene variants cohort. For the mouse cohort, amassed deep broad open-access phenome consisting ∼4,500 metabolic, physiological, pharmacological behavioural traits, more than 90 independent expression...
A remarkably diverse set of traits maps to a region on mouse distal chromosome 1 (Chr 1) that corresponds human Chr 1q21-q23. This is highly enriched in quantitative trait loci (QTLs) control neural and behavioral phenotypes, including motor behavior, escape latency, emotionality, seizure susceptibility (Szs1), responses ethanol, caffeine, pentobarbital, haloperidol. also controls the expression large number genes, genes are associated with some classical map (e.g., susceptibility). Here, we...
What proportion of genes with intense and selective expression in specific tissues, cells, or systems are still almost completely uncharacterized respect to biological function? In what ways do these functionally enigmatic differ from well-studied genes? To address two questions, we devised a computational approach that defines so-called ignoromes. As proof principle, extracted analyzed large subset brain. We find publications associated this set highly skewed—the top 5% absorb 70% the...
High-density genetic map provides an essential framework for accurate and efficient genome assembly QTL fine mapping. Construction of high-density maps appears more feasible since the advent next-generation sequencing (NGS), which eases SNP discovery high-throughput genotyping large population. In this research, a high density cucumber (Cucumis sativus) was successfully constructed across F2 population by recently developed specific length amplified fragment (SLAF-seq) method. total, 18.69...
Cucumber is an agriculturally and economically important vegetable crop worldwide. Fruit flesh thickness trait for cucumber also a central determinant of yield, yet little known about the underlying mechanism this trait. In study, bulked segregant analysis (BSA) combined with specific length amplified fragment sequencing (SLAF-seq) was applied to finely map gene that underlies fruit in cucumber. A 0.19-Mb-long quantitative locus on chromosome 2 controlling (QTL fft2.1) identified further...
GABA type-A (GABA-A) receptors containing the α2 subunit (Gabra2) are expressed in most brain regions and critical modulating inhibitory synaptic function. Genetic variation at GABRA2 locus has been implicated epilepsy, affective psychiatric disorders, alcoholism drug abuse. Gabra2 expression varies as a function of genotype is modulated by sequence variants several structures populations, including F2 crosses originating from C57BL/6J (B6J) BXD recombinant inbred family derived B6J DBA/2J....
Hundreds of inbred mouse strains and intercross populations have been used to characterize the function genetic variants that contribute disease. Thousands disease-relevant traits characterized in mice made publicly available. New including consomics, collaborative cross, expanded BXD, wild-derived add existing complex disease models, mapping populations, sensitized backgrounds for engineered mutations. The genome sequences strains, along with dense genotypes from others, enable integrated...
Abstract Background There is growing evidence of a strong correlation between pain sensitivity and cognitive function under both physiological pathological conditions. However, the detailed mechanisms remain largely unknown. In current study, we sought to explore candidate genes common molecular underlying with transcriptome‐wide association study using recombinant inbred mice from BXD family. Methods The determined by Hargreaves' paw withdrawal test cognition‐related phenotypes were...